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Open Access Article
1 - Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat
Md Rafiul Haque Md Afroz Ahmad Kamran Ashraf Md Habban Akhter Mohammad Jameel Abuzer Ali Wasim Akhtar Monika Dhaka Kavita RanaIn the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, MoreIn the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p < 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p < 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models. Manuscript profile
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