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Open Access Article
1 - Chemical constituents from the leaves and liana of Salacia nitida (Benth.) N.E.Br. (Celastraceae) and their antimicrobial activities
Brice Mba’ning Joël E. T. Ateba Angelbert F. Awantu Luciana S. Amaral Gervais M. Happi Beate Neumann Georg Stammler Bruno Lenta Silvère A. Ngouela Iran Malavazi Etienne Tsamo Norbert Sewald Edson Rodrigues-FilhoOne benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), MoreOne benzophenone, 4′-hydroxy-2,4,6-trimethoxybenzophenone (1) was isolated from the liana and leaves of Salacia nitida (Benth.) N.E.Br., together with n-hexacosane (2), 29-hydroxyfriedelane (3), 3β-friedelinol (4), n-hexacosan-1-ol (5), n-octacosan-1-ol (6), mangiferin (7), β-sitosterol-3-O-β-D-glucopyranoside (8), friedelin (9), 30-hydroxyfriedelin (10), salaspermic acid (11), 22β-epi-maytenfolic acid (12), orthosphenic acid (13), maltose (14), D-mannitol (15), cangoronine (16), 7-hydroxyfriedelane-1,3-dione (17), tingenone (18), pristimerin (19), α-amyrin acetate (20), β-sitosterol (21) and stigmasterol (22), 21-hydroxyfriedelan-3-one (23), abruslactone A (24), and 2α-hydroxypopulnonic acid (25). The structures of the isolated compounds were established by means of spectroscopic analysis. In addition, the structure of (1) was confirmed by its X-ray diffraction. Compounds (1), (7), (10)-(11), (13), (16)-(19) and (25) were evaluated for their antimicrobial activities. Compound (18) showed a significant activity against Staphylococcus aureus (MIC = 23.8 µM) while compounds (11) and (19) exhibited moderate inhibiting effect against Staphylococcus aureus (MIC = 53.8 µM) and Candida glabrata (MIC = 105.9 µM), respectively. Manuscript profile -
Open Access Article
2 - Characterization of bioactive compounds from Ficus vallis-choudae Delile (Moraceae)
Jean Jules Kezetas Bankeu Amadou Dawé Marius Mbiantcha Guy Raymond Feuya Iftikhar Ali Marthe Aimée Tchuente Tchuenmogne Lateef Mehreen Bruno Lenta Muhammad Ali Augustin Silvère NgouelaFicus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide n MoreFicus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity. Manuscript profile
List of Articles S.A. Ngouela
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