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Open Access Article
1 - Understanding the phytochemical constitution, antioxidant potential and spectral characteristics of aqueous extracts of the chosen leafy vegetables from south India
Sobha Kota Pradeep Dumpala Hariseetharam Prasad Dachepalli Anantha Ratna KumariThe phytochemical composition, total phenolic and ascorbic acid contents of the aqueous extracts of six south Indian leafy vegetables viz. Amaranthus viridis L, Hibiscus cannabinus L, Spinacea oleracea L, Mentha spicata L, Murraya koenigii L and Coriandrum sativum L wer MoreThe phytochemical composition, total phenolic and ascorbic acid contents of the aqueous extracts of six south Indian leafy vegetables viz. Amaranthus viridis L, Hibiscus cannabinus L, Spinacea oleracea L, Mentha spicata L, Murraya koenigii L and Coriandrum sativum L were tested, characterized and the antioxidant potential evaluated. Also, aqueous leaf extracts of A. viridis and H. cannabinus were demonstrated for their ability to form silver nanoparticles. All the aqueous extracts demonstrated the presence of flavonoids, saponins, tannins (except M. koenigii) and terpenoids (except S. oleracea) while phlobatannins (only in M. spicata), steroids, cardiac glycosides, alkaloids and proteins were absent in all the leaves tested. Carbohydrates were found only in the aqueous extract of H. cannabinus. The total phenolic content was the order of 0.9, 0.2, 1.8, 0.8 and 2.1 mgGAE/g of the leaves for A. viridis, H. cannabinus, M. spicata, M. koenigii and C. sativum respectively while S. oleracea did not respond to total phenolic content assay by FC method. Ascorbic acid, present in all the leafy vegetables with the lowest value of 0.3 mg/g in M. spicata and highest value of 1.9 mg/g in C. sativum. A highly significant DPPH radical scavenging activity was found in H. cannabinus (82.76%) followed by M. spicata (78.08%) and C. sativum (69.76%) at an extract concentration of 31.25 mg/ml while A. viridis, S. oleracea and M. koenigii showed 72.95%, 58.27% and 75.38% respectively at a concentration of 50 mg/ml. FT-IR spectral characterization of the extracts and the synthesized silver nanoparticles (Ag NPs) indicated the presence of N-H amines, O-H stretch, C-H out of plane bending vibrations, C=C stretching of alkenes, C=O stretch of amide and C≡C stretch of alkynes. The leafy vegetables can be used for the synthesis of lead compounds which will cure diseases. Manuscript profile -
Open Access Article
2 - Phytoconstituents of Chromolaena odorata (L.) leaf extract for the synthesis of copper oxide/copper nanoparticles and evaluation of their biological potential in wound healing
Sobha Kota Pradeep Dumpala Radhika Sajja Ratnakumari AnanthaChromolaena odorata (L.), locally named Siam weed, is a rich source of phyto-bioactives and has been traditionally used for wound healing. This study deals with the phytochemical investigation of the leaves of C. odorata (L.) for their antioxidant, anti-inflammatory, an MoreChromolaena odorata (L.), locally named Siam weed, is a rich source of phyto-bioactives and has been traditionally used for wound healing. This study deals with the phytochemical investigation of the leaves of C. odorata (L.) for their antioxidant, anti-inflammatory, and antibacterial properties that contribute to the observed wound healing properties. The phytoconstituents were sequentially extracted from the powdered leaves of C. odorata (L.) and chemoprofiled using the LC-MS technique. Furthermore, copper oxide/copper nanoparticles (CuNPs) were synthesized by the use of water extracts from the leaves of C. odorata (L.), characterized and evaluated for their potential biological and wound healing impacts. In this relation, scutellarein, isosakuranetin, and rutin, along with 15 other phytoconstituents were identified. Higher antioxidant (79.2% at 200 μg/mL) and anti-inflammatory potentials (66.8%) were obtained for CuNPs (120 μg/mL), in the size range of 66.8 ± 24.8 nm. Antibacterial activity against methicillin-resistant Staphylococcus aureus and Pseudomonas sp. demonstrated mean zones of inhibition of 16.7 ± 4 mm and 17.73 ± 2 mm, respectively. Hence, the synthesized CuNPs would be desirable for inclusion in nanofibrous medical dressings. Manuscript profile
List of Articles S. Kota
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