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Open Access Article
1 - Triterpenic and acyl glycosides from the leaves of Centella asiatica (L.) Urban
Iram Rais Mohammad AliCentella asiatica (L.) Urban (Apiaceae) is a small perennial, prostrate herb indigenous to India, south-eastern Asia, United States and Africa. It is used to treat anxiety, asthma, blood circulation, cancer, colds, cough, elephantiasis, epilepsy, fevers, gastrointestina MoreCentella asiatica (L.) Urban (Apiaceae) is a small perennial, prostrate herb indigenous to India, south-eastern Asia, United States and Africa. It is used to treat anxiety, asthma, blood circulation, cancer, colds, cough, elephantiasis, epilepsy, fevers, gastrointestinal problems, hepatic, skin and urinary tract diseases, hydrocele, hypertension, hysteria, insomnia, rheumatism, scleroderma, strangury, ulcers and wounds. Plants have an enormous potential for the management and treatment of different kind of illness. The active constituents of this plant induce the healing and regeneration of the lost tissue by multiple mechanisms. Plants gives us phytomedicines and these phytomedicines are not only cheap and affordable but are also safe as hyper sensitive reactions are rarely encountered with the use of these agents. The presence of various life-sustaining constituents in plants has urged scientist to examine these plants with a view to determine potential wound healing properties Phytochemical investigation of a methanolic extract of the leaves resulted in the isolation of five new compounds characterized as urs-12-en-3β-ol-28-oic acid-3-O-β-D-glucopyranosyl-2′- arachidate (ursolic acid glucosidic arachidate (1), urs-12-en-3β-ol-28-oic acid 3-O-β-D-xylopyranosyl-(2′→1′′)-O-β-D- xylopyranoside (ursolic acid 3-O-β-D-dixyloside (3), n-dodecanoyl-O-β-D-glucopyranosyl-(6′→1′′)-O-β-D-glucopyranosyl-(6′′→1′′′)-O-β-D-glucopyranosyl-6′′′→1′′′′)- O-β-D-glucopyranoside (lauroyl tetraglucoside (5), n-octanoyl-O-β-D-glucopyranosyl-(6a→1b)-O-β-D-glucopyranosyl-(6b→1c)-O-β-D-glucopyranosyl-(6c→1d)-O-β-D-glucopyranosyl-(6d→1e)–O-β-D-gluco- pyranoside (caproyl pentaglucoside (6) and ursan-3β-ol-28-al-3-O-α-L-arabinopyranosyl-(2a→1b)-O-α-L-arabinopyranosyl-(2b→1c)-O-α-L-arabinopyranosyl-(2c→1d)-O-α-L-glucopyranosyl-(2d→1e)-O-α-L-glucopyranosyl-(2e→1f)-O-α-L-glucopyranoside (ursolic aldehyde 3-O-α-L-hexaglycoside (7) along with two known phytoconstituents identified as n-decanoyl-O-β-D-glucopyranosyl- (6′→1′′)-O-β-D- glucopyranoside (n-capryl diglucoside (2) and glyceryl 1-decanoyl –2- phosphate (4), The structures of these phytoconstituents have been elucidated on the basis of spectral analysis and chemical reactions. Manuscript profile -
Open Access Article
2 - Phytochemical investigation and isolation of new compounds from the stems of Tinospora cordifolia Miers
Shahnaj Sultana Mohammed Ali Mohammad JameelTinospora cordifolia (Willd.) Miers, (Menispermaceae), a glabrous, deciduous and trailing plant found in tropical India, China, Sri Lanka, Bangladesh and Myanmar. It is used to treat anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fevers, jaundice, rheumatis MoreTinospora cordifolia (Willd.) Miers, (Menispermaceae), a glabrous, deciduous and trailing plant found in tropical India, China, Sri Lanka, Bangladesh and Myanmar. It is used to treat anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fevers, jaundice, rheumatism, urinary and skin diseases and snake bites. Its air-dried stem powder was exhaustively extracted with methanol. The concentrated methanolic extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of new chemical constituents characterized as trans-cinnamoyl 2-n-hexanyl-7-methoxynaphthyl amide (2), trans-cinnamoyl 2-n- pentanyl- 6,7- dimethoxynaphthyl amide (3), trans-cinnamoyl 2-n-octanyl-7-methoxynaphthyl amide (4), β-D-arabinosyl-O-geranilan-10′-oate (5), 4,5,7-trimethoxy-2-naphthol-2-O-α-L- arabinofuranosyl-(2′→1′′)-O-α-L-arabinopyranosyl-2′′-O-pentane (6), 5,7-dimethoxy-2-naphthol-2-O-α-L-arabinopyranosyl-(2′→1′′)-α-L- arabinopyranosyl-2′′-O-decane (7) and 5-hydroxy-4''-methoxy-7- flavanoxy- (7→7'''')- β-O-labdan-1-en-3''''α,19''''-olide-18''''-oic acid (tinolabdenyl flavanone) (8) along with cetyl alcohol (1). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions. Manuscript profile -
Open Access Article
3 - Chemical constituents from the fruits of Withania coagulans (Stocks) Dunal
Showkat Rassol Mir Mohammed Ali Mohammad Waris Shahnaz SultanaWithania coagulans (Stocks) Dunal (family: Solanaceae) is a rigid undershrub found in Iran, Afghani stan, Pakistan, northern India and Nepal. Its fruits are used to treat asthma, biliousness, flatulent colic, cough, diabetes, dyspepsia, liver complaints, intestinal infe MoreWithania coagulans (Stocks) Dunal (family: Solanaceae) is a rigid undershrub found in Iran, Afghani stan, Pakistan, northern India and Nepal. Its fruits are used to treat asthma, biliousness, flatulent colic, cough, diabetes, dyspepsia, liver complaints, intestinal infections, skin rashes, stomachache, strangury and wounds. The air-dried fruits of W. coagulans were exhaustively extracted with methanol in a Soxhlet apparatus. The concentrated methanol extract was adsorbed on silica gel to be chromatographed on a silica gel column. The column was eluted with dichloromethane, ethyl acetate and methanol suc cessively to isolate ten new phytoconstituents characterized as (3R,4R)-dihydroxyadipic-γ,γ’-dilactone (n-hexa-1(3),4(5)-diolide, 2), (20S,22R)-1-oxo-witha-2,24-dienolide (withacoagulanide A, 3), (20S,22R)- 1-oxo-witha-24-enolide (withacoagulanide B, 4), (20S,22R)-1-oxo-witha-6β-ol-2,24-dienolide (witha coagulanide C, 5), (20S,22R)-1-oxo-witha-3β,5β-diol-24-enolide (withacoagulanide D, 6), (20S,22R)-1- oxo-witha-6β-ol-2,24-dienolide-6β-D-arabinopyranosyl-2′-(2′′-methoxy)-benzoate (withacoagunalide C 6-arabinosyl 2′-O-anisate, 7), (20S,22R)-1-oxo-witha-3β-ol-24-enolide-3β-O-D-galactoyranosyl- (2′→1′′)-β-O-D-galactopyranoside (3-O-digalactosyl withacoagulanide B, 8), 1-oxo-3-seco-witha-21, 27, 28-trioic acid-24-ene-6β-ol-19(8), 18(11)-diolide-6β-O-D-galacuronopyranoside (3-secowithacoag ulanolide 6β-olyl galactourinoside, 10), (20S,22R)-1-oxo-witha-6β-ol-2,24-enolide-6β-O-D-(4′-acetoxy arabinopyranosyl-(2′→1′′)-(3′′,4′′-diacetoxy arabinopyranosyl)-2′′-(2′′′-methoxy)-benzoate (withacoag ulanide C 6β-olyl diarabinosyl 2′′-(O)-anisate, 11) and n-hexanoyl-β-O-D-xylopyranosyl-(2′→1′′)-β-O-D-xylopyranosyl-(2′′→1′′′)-β-O-D-xylopyrano- side (caproyl trixyloside, 12) along with the known rare chemical compounds identified as cetyl palmitate (hexadecyl hexadecanoate, 1) and glyceryl-1,2-di hexadecanoate-3-phosphate (glyceryl-1,2-dipalmityl 3-phosphate, 9). The structures of isolated phyto constituents were established on the basis of analysis of spectral data and chemical means. Manuscript profile -
Open Access Article
4 - Chemical constituents from the leaves of Fraxinus excelsior L., Senna sulfurea (Collad.) H. S. Irwin et Barneby and Prosopis cineraria (L.) Druce
Shahnaz Sultana Mohammed Ali Mohammad Jameel Piyush SharmaFraxinus excelsior L. (Oleaceae) is used to treat diarrhoea, dysentery, jaundice, joint pain, malaria, sores, swelling and wounds. The leaves of Senna sulfurea (Collad.) H. S. Irwin et Barneby (Leguminosae) are effective to cure blennorrhagia, diabetes, dysentery, gonor MoreFraxinus excelsior L. (Oleaceae) is used to treat diarrhoea, dysentery, jaundice, joint pain, malaria, sores, swelling and wounds. The leaves of Senna sulfurea (Collad.) H. S. Irwin et Barneby (Leguminosae) are effective to cure blennorrhagia, diabetes, dysentery, gonorrhea and skin diseases. Prosopis cineraria (L.) Druce, (Fabaceae) is taken to alleviate anxiety, asthma, bronchitis, dysentery, dyspepsia, fever, leprosy, leucoderma, muscle tremors, piles, rheumatism and tremors. Our study was planned to isolate chemical constituents of the methanolic extracts obtained from the leaves of F. excelsior, S. sulfurea and P. cineraria and to characterized their structures. The air-dried plant materials were exhaustively extracted with methanol separately in a Soxhlet. The concentrated methanolic extracts were adsorbed on silica gel (60-120 mesh) for the preparation of slurries. The dried slurries were chromatographed over silica gel columns individually packed in petroleum ether. The columns were eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of phytoconstituents. Phytochemical investigation of the leaves of F. excelsior afforded (Z,Z,Z)-n-tetratriacont-3,5,15-triene (1), n-hexatriacontane (2), (Z,Z,Z)-n-octatriacont-11,13,20-triene (3), phytanic acid (3,7,11,15-tetramethylhexadecanoic acid, 4), 26-hydroxystigmasterol-18-oic acid (5) and α-L-xylose (6). The leaves of S. sulfurea furnished isoliquiritigenin (7) and 4-methoxy-α-L-xylopyranosyl-(3→1′)-O-α-L-4′-methoxyxylopyranoside (di-4-methoxy-α-L-xyloside, 8). The leaves of P. cineraria on subjection to silica gel column chromatography led to isolate glyceryl-1-oleioyl-2-myristioyl-3-O-hydroxydihydrocinnamate (9), 2,3,4-trihydroxybenzyl n-hexadecanyl ether (10) and salicyloyl O-α-D-glucopyranosyl-2′-oleate (11). Their structures were established on the basis of spectral data analysis and chemical reactions. Manuscript profile
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