Metal complexes containing Schiff base ligand are compounds that have biological effects such as antifungal, antibacterial, anti-malarial, anti-inflammatory, anti-viral and anti-fever properties. These compounds are also used in various industries. In this study, Pallad More
Metal complexes containing Schiff base ligand are compounds that have biological effects such as antifungal, antibacterial, anti-malarial, anti-inflammatory, anti-viral and anti-fever properties. These compounds are also used in various industries. In this study, Palladium (II) Schiff base complex with the proposed formula C14H24N4O2Cl2Pd was synthesized by the method reported in Zabol University and used to investigate the antimicrobial effects. Antimicrobial activity such as antibacterial activity against pathogenic strains common between aquatic and human inclusive Loctococcus garvieae and Edwardsiella tarda strains and antifungal activity inclusive Aspergillus fumigatus and Candida albicans were performed according to CLSI standard and the results were reported based on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC). Based on the results, the studied complex showed MIC concentrations of 32 μg/ml and 64 μg/ml on the Edwardsiella tarda and Loctococcus garvieae, respectively. The MIC concentrations on Aspergillus fumigatus and Candida albicans, respectively, 512 μg/ml and 1024 μg/ml were observed. The results of this study showed that the effect of Pd (II) Schiff base complex has strong antimicrobial properties and has a better effect than some commercial drugs.
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Due to the growing interest of researchers in the synthesis of new chemical compounds that have diverse medicinal properties, in this study, the interaction of the complex of [Zn(SBL)2]Cl2 (SBL = Schiff base ligand 2(-iminoethyl)piperazine diacetyl monoxime) with human More
Due to the growing interest of researchers in the synthesis of new chemical compounds that have diverse medicinal properties, in this study, the interaction of the complex of [Zn(SBL)2]Cl2 (SBL = Schiff base ligand 2(-iminoethyl)piperazine diacetyl monoxime) with human and bovine serum albumin proteins (HSA and BSA) in tris-buffer medium was investigated by spectroscopic methods. The results for both complexes were almost identical, as fluorescence spectroscopy showed that the inherent fluorescence quenching of both proteins is due to the interaction of the zinc complex through a static quenching mechanism. The zinc complex interacted with both proteins with almost the same affinity. Thermodynamic parameters showed the contribution of hydrogen bonding and van der Waals interactions, but the role of hydrophobic interactions is not insignificant due to the presence of the imine group in the complex structure and the small amount of ∆S. Structural changes during the interaction of zinc complex with two proteins were investigated by synchronous‎ fluorescence methods as well as circular dichroism. The results of synchronous‎ ‎ fluorescence showed that during the interaction of the complex with proteins no noticeable polarity change occurred around the tryptophan residue while around the tyrosine residue the polarity changed. The study of circular dichroism spectroscopy also shows a decrease in the content of the alpha helix in both complexes. The results of this study confirm that the interaction of the zinc complex in both proteins is almost similar, so sometimes in pharmacological studies it can be used instead of human protein from its animal family.
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In this study, two sulfonamide – Schiff base compounds "N'-(2-hydroxy-3-methoxybenzylidene)-4-methylbenzenesulfonohydrazide and 1,2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine) (1) and N'-(2-hydroxy-3-methoxybenzylidene)-4-nitrobenzenesulfonohydrazide and 1,2-bis( More
In this study, two sulfonamide – Schiff base compounds "N'-(2-hydroxy-3-methoxybenzylidene)-4-methylbenzenesulfonohydrazide and 1,2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine) (1) and N'-(2-hydroxy-3-methoxybenzylidene)-4-nitrobenzenesulfonohydrazide and 1,2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine) (2)" were synthesized by sulfonyl chloride and Schiff base compounds. Copper and zinc oxides were coated by synthesized compounds and were tested for antibacterial activity. All compounds were identified by NMR and FTIR spectra, X-ray diffraction (XRD), and elemental analysis. Scanning Electron Microscope SEM was used for the morphology of micro metal oxides before and after coating with Sulfonamide-Schiff bases compounds. Accordingly, antibacterial activity of compounds against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus saprophyticus) and Gram-negative bacteria (Proteus mirabilis) were tested. It should be noted that both have high antimicrobial activities. The result of the study shows that the antibacterial activities of the synthesized sulfonamide-schiff bases against gram positive and gram negative bacteria decrease after coating on micro metal oxides. It is also worth mentioning that Ampicilin and Penicilin have been utilized as two standard medicines for investigating the antibacterial activities.
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The interaction of Re )I( tricarbonyl-diimine complex )]Re[( with calf thymus DNA (CT-DNA) was investigated by using UV–Vis, fluorescence spectrophotometry, circular dichroism )CD( spectroscopy, thermal denaturation, and cyclic voltammetry )CV( studies. The bindin More
The interaction of Re )I( tricarbonyl-diimine complex )]Re[( with calf thymus DNA (CT-DNA) was investigated by using UV–Vis, fluorescence spectrophotometry, circular dichroism )CD( spectroscopy, thermal denaturation, and cyclic voltammetry )CV( studies. The binding constant value Kb of complex ]Re[ was found to be 5.47×106 M-1 using UV-Vis spectrophotometry data. The results show that the ]Re[ complex has relatively good interaction in comparison to other Schiff base complexes, indicating that the ]Re[ complex binds to DNA by electrostatic and partial intercalation modes. In addition, the intercalation mode is dominant via electrostatic interaction, as the most experiments confirm it
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The inhibiting action of Schiff base and polyethylene glycol (Salpn-PEG) complexes on low-carbon steel corrosion in 0.5 M sulfuric acid was examined using weight loss, potentiodynamic polarization and spectroscopy electrochemical impedance (EIS) techniques. Schiff base More
The inhibiting action of Schiff base and polyethylene glycol (Salpn-PEG) complexes on low-carbon steel corrosion in 0.5 M sulfuric acid was examined using weight loss, potentiodynamic polarization and spectroscopy electrochemical impedance (EIS) techniques. Schiff base N, N’-bis(salicyladehyde)-1,3-diaminopropane (Salpn) was synthesized by salicylaldehyde and 1,3- diaminopropane. PEG/Salpn complex with weight ratio 1:4, 2:4 and 3:4 of Salpn and PEG were prepared in methylene chloride solvent by a simple deporotonation procedure. Obtained Results show that PEG/IMZ complex is very effective corrosion inhibitor of carbon steel in the acid environment in compare with PEG, Salpn and noncomplex form of them. Maximum corrosion inhibition was obtained for PEG/Salpn complex with weight ratio 1:4 of Salpn and PEG. The inhibition efficiency increased with the increase in the temperature up to 45°C and decrease in higher temperatures. Results from all the corrosion tests were examined using SEM and are in reasonable good agreement. Adsorption thermodynamic data (〖K 〗_ads and 〖∆G〗_ads ) was calculated using the weight loss data
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