Study of Calf thymus DNA interaction with Schiff base Re (I) tricarbonyl-diimine complex using different spectroscopic techniques

Subject Areas :

مریم  بردبار ¹ (استادیار شیمی تجزیه گروه شیمی، دانشکده علوم پایه، دانشگاه قم، ایران)
فریبا  طاووسی ² (کارشناس ارشد گروه شیمی، دانشکده علوم پایه، دانشگاه پیام نور، مرکز قم، ایران)
علی  یگانه فعال ³ (کارشناس ارشد گروه شیمی، دانشکده علوم پایه، دانشگاه پیام نور، مرکز قم، ایران)
اکبر  رستمی ورتونی ⁴ (استادیار شیمی تجزیه گروه شیمی، دانشکده علوم پایه، دانشگاه قم، ایران)

Received: 2018-03-05 Accepted : 2018-07-05 Published : 2018-08-23

Keywords: DNA binding, Schiff base ligand, Intercalation Interaction, Rhenium complex,

Abstract :

The interaction of Re )I( tricarbonyl-diimine complex )]Re[( with calf thymus DNA (CT-DNA) was investigated by using UV–Vis, fluorescence spectrophotometry, circular dichroism )CD( spectroscopy, thermal denaturation, and cyclic voltammetry )CV( studies. The binding constant value Kb of complex ]Re[ was found to be 5.47×106 M-1 using UV-Vis spectrophotometry data. The results show that the ]Re[ complex has relatively good interaction in comparison to other Schiff base complexes, indicating that the ]Re[ complex binds to DNA by electrostatic and partial intercalation modes. In addition, the intercalation mode is dominant via electrostatic interaction, as the most experiments confirm it

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