*Corresponding author Email:Journal of Applied Research in Chemistry143JARCStudy of biological activity of sulfonamide-schiff bases compounds coating with zinc (II) and copper(II) micro oxides

Subject Areas :

محمد یوسفی ¹ , مژگان تحریری ² , معصومه طباطبایی ³ , خیراله مهرانی ⁴ , محمود دهقانی اشکذری ⁵

1 - گروه شیمی واحد علوم و تحقیقات دانشگاه آزاد اسلامی، تهران
2 - دکتری شیمی معدنی، دانشگاه علوم و تحقیقات، تهران، ایران
3 - استاد شیمی معدنی، دانشگاه آزاد اسلامی، یزد، ایران
4 - استادیار شیمی معدنی، دانشگاه علوم و تحقیقات، تهران، ایران
5 - استادیار زیست‌شناسی، دانشگاه آزاد اسلامی، اشکذر- یزد، ایران

Received: 2016-11-08 Accepted : 2018-02-07 Published : 2018-05-22

Keywords: Schiff base, Antibacterial activity, Sulfonyl chloride, Micro particles zinc oxide, Micro particles copper oxide,

Abstract :

In this study, two sulfonamide – Schiff base compounds "N'-(2-hydroxy-3-methoxybenzylidene)-4-methylbenzenesulfonohydrazide and 1,2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine) (1) and N'-(2-hydroxy-3-methoxybenzylidene)-4-nitrobenzenesulfonohydrazide and 1,2-bis(2-hydrxy-3-methoxy-benzylidenehydrazine) (2)" were synthesized by sulfonyl chloride and Schiff base compounds. Copper and zinc oxides were coated by synthesized compounds and were tested for antibacterial activity. All compounds were identified by NMR and FTIR spectra, X-ray diffraction (XRD), and elemental analysis. Scanning Electron Microscope SEM was used for the morphology of micro metal oxides before and after coating with Sulfonamide-Schiff bases compounds. Accordingly, antibacterial activity of compounds against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus saprophyticus) and Gram-negative bacteria (Proteus mirabilis) were tested. It should be noted that both have high antimicrobial activities. The result of the study shows that the antibacterial activities of the synthesized sulfonamide-schiff bases against gram positive and gram negative bacteria decrease after coating on micro metal oxides. It is also worth mentioning that Ampicilin and Penicilin have been utilized as two standard medicines for investigating the antibacterial activities.

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