Evaluation of antifungal and antibacterial properties of palladium (II) Schiff base complex against common pathogenic strains between humans and aquatic

Subject Areas :

Mohammadreza Moghaddam-manesh ¹ , Somaye Shahriari ² , Sara Hosseinzadegan ³

1 - Petrochemistry and Polymer Research Group, Chemistry and Petrochemistry Research center, Standard Research Institute, Iran
2 - Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
3 - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Received: 2021-07-19 Accepted : 2022-01-15 Published : 2022-05-22

Keywords: Schiff base, Metal complex, Antimicrobial agents, Common pathogenic strains between humans and aquatic,

Abstract :

Metal complexes containing Schiff base ligand are compounds that have biological effects such as antifungal, antibacterial, anti-malarial, anti-inflammatory, anti-viral and anti-fever properties. These compounds are also used in various industries. In this study, Palladium (II) Schiff base complex with the proposed formula C14H24N4O2Cl2Pd was synthesized by the method reported in Zabol University and used to investigate the antimicrobial effects. Antimicrobial activity such as antibacterial activity against pathogenic strains common between aquatic and human inclusive Loctococcus garvieae and Edwardsiella tarda strains and antifungal activity inclusive Aspergillus fumigatus and Candida albicans were performed according to CLSI standard and the results were reported based on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC). Based on the results, the studied complex showed MIC concentrations of 32 μg/ml and 64 μg/ml on the Edwardsiella tarda and Loctococcus garvieae, respectively. The MIC concentrations on Aspergillus fumigatus and Candida albicans, respectively, 512 μg/ml and 1024 μg/ml were observed. The results of this study showed that the effect of Pd (II) Schiff base complex has strong antimicrobial properties and has a better effect than some commercial drugs.

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