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Open Access Article
1 - The effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of rats with Alzheimer's disease
Fakhradin Hassanlouei Seyed Ali Hoseini Laleh Behbudi Tabrizi Masod Haji Rasouli -
Open Access Article
2 - Effects of adding royal jelly to Tris-egg yolk extender on Afshari ram sperm parameters after liquid storage of semen
Amini, S., Masoumi, R., Rostami, B., Shahir, M.H. .The present study was conducted to evaluate the protective effects of royal jelly in Tris based extender on ram sperm parameters including motility, viability, morphology and plasma membrane integrity during 7 days liquid storage. 64 semen samples were collected with ar MoreThe present study was conducted to evaluate the protective effects of royal jelly in Tris based extender on ram sperm parameters including motility, viability, morphology and plasma membrane integrity during 7 days liquid storage. 64 semen samples were collected with artificial vagina from 4 rams. After initial assessments, semen samples were mixed and then were diluted with Tris based extender having 0 (control), %1, %3 and %5 royal jelly. Motility was assessed with CASA system. Morphology and viability were assessed with Eosin-Negrosin staining method and plasma membrane integrity was assessed with HOST method. Diluted semen samples were kept in 37° for 1 hour and 4° C for 7 days. The results showed that motility percentage (51.25±2.86) in %3 royal jelly supplemented group was significantly higher than other treatment groups after 7 days’ liquid storage of semen (P< 0.05). The percentage of sperm cells with functional plasma membrane (46.53± 2.96) in %3 royal jelly supplemented group was significantly higher than control group (P< 0.05). The percentage of live sperm cells in %3 (56.96±3.37) and in 1% (54.68±2.83) royal jelly supplemented groups were higher than control group (P< 0.05). In conclusion, the results of present study showed that supplementation of %3 royal jelly to Tris based extender improves ram sperm parameters after 7 days’ liquid storage of semen. Manuscript profile -
Open Access Article
3 - Protective effect of aerobic training and royal jelly on profibrogenic parameters of liver tissue and insulin resistance in obese rats
Ali Asghar Ma&#039;ghouli Ahmad Abdi asieh abbassi daloiiIntroduction: Obesity is characterized by several metabolic complications such as increased profibrogenic parameters of liver tissue. Most anti-obesity drugs have liver side effects. The aim of this study was to investigate the protective effect of aerobic training and MoreIntroduction: Obesity is characterized by several metabolic complications such as increased profibrogenic parameters of liver tissue. Most anti-obesity drugs have liver side effects. The aim of this study was to investigate the protective effect of aerobic training and royal jelly on profibrogenic parameters of liver tissue and insulin resistance in obese rats.Materials and Methods: In this experimental study, 45 male Wistar rats were divided into 5 groups: normal diet (ND), high fat diet (HFD), high fat diet - training (HFDT), high fat diet - royal jelly (HFDRJ) and high fat diet - training - royal jelly (HFDTRJ). The supplement groups received 100 mg of royal jelly (per kg of body weight) diluted in distilled water orally during the intervention period. Aerobic training program including running on treadmill with intensity of 50-60% VO2max was performed 5 days week for eight weeks. The genes expression of Transforming Growth Factor β (TGF-β) and Smad3 were measured by Real Time PCR. Results: There was significant increase of TGF-β, Smad3 and insulin resistance in HFD, HFDT, HFDRJ and HFDTRJ groups compared to ND group (P=0.001). Also, there was a significant decrease of TGF-β, Smad3 and insulin resistance in HFDT, HFDRJ and HFDTRJ groups compared to HFD group; and HFDTRJ compared to HFDRJ groups (P=0.001).Conclusion: It seems that the aerobic training with royal jelly can help to decrease of insulin resistance and improve the profibrogenic parameters of liver tissue in obesity caused by high-fat diet. Manuscript profile -
Open Access Article
4 - Study on Predictive Models Relating Physico-chemical Properties of Iranian Royal Jelly and it’s Sensory Evaluation
soheila kamyab Maryam Gharachorloo Masoud Honarvar Mehrdad Ghavami -
Open Access Article
5 - The Protective Effects of Royal Jelly on the Histomorphometric ,Hormonal Alternation and Oxidative Stress in Ofloxacin Treated Male Rat
Ghodrat Ebadi ManasInroduction & Objective: Royal jelly is a compound that is produced by the worker honey bees. This compound has antioxidant activity and protective effects against oxidative stress. The aim of this study were to determine protective role of royal jelly on decrease side MoreInroduction & Objective: Royal jelly is a compound that is produced by the worker honey bees. This compound has antioxidant activity and protective effects against oxidative stress. The aim of this study were to determine protective role of royal jelly on decrease side effects of ofloxacin and return reproductive function near normal rang in ofloxacin treated male ratMaterial and Methods:In this experimental work used 32 male albino rats that each has body weight between 160-18o gand accidentally divided to 4 groups: ofloxacin, royal jelly , ofloxacin with royal jelly and control. Each group included 8 rats. Dosage for ofloxacin group was 216 mg/kg.BW ofloxacin and for royal jelly group was 100 mg/kg.BW royal jelly. Royal Jelly with ofloxacin group received 216 mg/kg ofloxacin and100 mg/kg royal jelly. Control group received distilled water at dose of 216 mg/kg.BW. All groups received dose - related daily for 28 days orally. Data analyzed by one-way ANOVA and used Turkey HSD Post-test to compare the significance of difference. Results: After exposure ofloxacin results revealed thatdiameter of seminiferous tubules, thickness of epithelium seminiferous tubules, weight testes,FSH, LH, testosterone, TTM ,TAOCand RI in compared to control significance decline,but distance between seminiferous tubule ,TDI , SI, MDA and NO significanceincreased. All parameters were improved to near normal rang level after exposure royal jelly.Conclusion:This investigation revealed that ofloxacin has negative effect on histomorphometry and reproductive function in mature male rats,but at the same time if you use royal jelly it is protects against ofloxacin and retune to normal rang. Manuscript profile -
Open Access Article
6 - The effect of eight weeks of HIIT and N-chromosome royal jelly on liver enzymes and insulin resistance index in type 2 diabetic obese rats
sahar Riasati Hossein Abednatanzi Mandana GholamiBackground & Aim: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand, which leads to be changes in liver enzymes with structural and functional changes in the liver. The aim of MoreBackground & Aim: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand, which leads to be changes in liver enzymes with structural and functional changes in the liver. The aim of this study was to study changes in liver enzymes and insulin resistance index after HIIT and royal jelly in obese rats with type 2 diabetes. Materials & Methods: The statistical sample of the present study was 36 obese male rats with an average weight of 409 gr. After 20 weeks of high-fat diet, rats became diabetic by intraperitoneal injection of 25 mg/kg STZ body weight. Mice with fasting glucose between 150 and 400 mg /dl were considered to have type 2 diabetes. Diabetic rat in 4 groups of control (N=6), HIIT (N=8), royal gel (N=7), HIIT& Royal gel (N=8) group done and Accomplished Eight weeks of HIIT, 5d/w with intense 2-minute intervals of 80 to 90% VO2max and one-minute rest intervals with 50 to 56% VO2max. Royal jelly was given by gavage at the rate of 100 mg / kg 5 days a week. At the end of the protocol, blood samples were taken and liver enzymes and glucose were measured using an auto-analyzer and insulin was measured using a laboratory kit and analyzed using one-way and two-way analysis of variance and post hoc test. Results: showed that in comparison with the control group, HIIT led to a significant decrease in glucose and insulin resistance index and intermittent exercise resulted in a decrease in liver enzymes ALT, AST and ALP compared to the control group. The ALP decrease was significant (P = 0.001). Conclusion: It seems that HIIT and consumption of royal jelly can help reduce liver enzymes and improve liver status in rats. Manuscript profile -
Open Access Article
7 - The Effect of Aerobic Training with Royal Jelly Consumption on Insulin Resistance of Rats with MS
Abdolhamid Mosalla nezhad Farzaneh Taghian Khosro Jalali Dehkordi Seyed HosseiniIntroduction: Although the beneficial role of exercise and antioxidants in multiple sclerosis (MS) has been reported, the interactive effect of aerobic training (AT) and royal jelly (RJ) consumption on insulin resistance is still not well known. Therefore, the aim of th MoreIntroduction: Although the beneficial role of exercise and antioxidants in multiple sclerosis (MS) has been reported, the interactive effect of aerobic training (AT) and royal jelly (RJ) consumption on insulin resistance is still not well known. Therefore, the aim of the present study was to investigate the effect of of ET and RJ consumption on insulin resistance of MS rats.Materials and methods: In this experimental trial, 49 female Sprague-Dawley rats of EAE model weighing 180-210 gr were divided into seven groups based on their motor disability, including (1) experimental autoimmune encephalomyelitis (EAE), (2) sham (Sh), (3) 50 mg /kg of royal jelly consumption (RJ50), (4) 100 mg /kg of royal jelly consumption (RJ100), (5) aerobic training (AT), (6) AT+RJ50, and (7) AT+RJ100. In order to investigate the effects of EAE on the variables, 7 healthy rats were included in the healthy control group (HC). AT was performed for five weeks, four sessions per week at a speed of 11-15 m/min for 30 minutes, and RJ was injected intraperitoneally with the determined dose daily. To analyze the findings, one-way analysis of variance and Tukey's post hoc test were used (P≥0.05).Findings: Insulin resistance levels in the RJ50, RJ100, ET, ET+RJ50 and ET+RJ100 groups were significantly lower than the EAE group (P=0.01).Conclusion: It seems that aerobic training combined with royal jelly consumption has a synergistic and favorable effect on improving insulin resistance in rats with MS. Manuscript profile -
Open Access Article
8 - The effecte of eight weeks of resistance training with royal jelly on the pathaphysiological changes in the hippocampal tissue of Alzheimer's rats
Leila Mokhtari Tahereh Bagherpour Nematollah NematiAbstract Introduction: Oxidative stress plays role in the progression of Alzheimer's disease (AD).exercise and antioxidants on neuronal health have effect . the effect of eight weeks of resistance training (RT) along with royal jelly (RJ) on Malondialdehyde (MDA) MoreAbstract Introduction: Oxidative stress plays role in the progression of Alzheimer's disease (AD).exercise and antioxidants on neuronal health have effect . the effect of eight weeks of resistance training (RT) along with royal jelly (RJ) on Malondialdehyde (MDA), Protein Carbonylate (PC) and the pathological changes in the hippocampal tissue of Alzheimer's rats treated with trimethyltin (TMT)has been determined. Methods: In this experimental study, 42 male Sprague-Dawley rats treated with 8 mg/kg TMT were divided into TMT, Sham, RJ100, RJ200, RT, RT+RJ100 and RT+RJ200 groups. Supplemental groups received RJ with doses of 100 and 200 mg/kg/day as peritoneal injection, and the increasing RT protocol was performed for 8 weeks, 3 sessions a week with an intensity of 30 to 100% of the weight. Results: MDA, PC in TMT group were significantly higher than HC group. But MDA and PC in RT+RJ200 group were lower than TMT group (P≤0.05). Also, PC in RT group was significantly lower than TMT. MDA in RJ200 group were lower than TMT; PC values in RJ100 group was significantly lower than TMT (P≤0.05). The reducing effect of PC in RJ100 group was more favorable than RJ200 (P≤0.05). Also, the effect of reducing MDA in the RT+RJ200 group was more favorable than the RT+RJ100 group (P≤0.05). Conclusion:the resistance training and royal jelly have favorable effects on reducing oxidative stress. the simultaneous effect of these two interventions, especially with a higher dose, has a more favorable effect on reducing oxidative stress in the hippocampus tissue in AD modeling conditions. Manuscript profile -
Open Access Article
9 - The comparative study of antibacterial effects of Royal Jelly and Honey and the combination of them against standard strain of Helicobacter pylori
Nahid Rahimifard Behrang Hoseinzadeh shahram shoeibiHelicobacter pylori is a Gram-negative, microaerophilic spiral rod. About half of the world population is infected with the bacteria that cause gastric and duodenal ulcers, and if untreated and eradication lead to the gastric cancer. Treatment is not easy and requires t MoreHelicobacter pylori is a Gram-negative, microaerophilic spiral rod. About half of the world population is infected with the bacteria that cause gastric and duodenal ulcers, and if untreated and eradication lead to the gastric cancer. Treatment is not easy and requires the administration of high doses of combination antibiotic with extensive and repeated use, in addition to side effects, the incidence of bacterial resistance as a double challenge is posed. So finding an alternative treatment, such as new natural antimicrobial resources including bee products such as honey and royal jelly is necessary. Honey due to high osmolality, low acidity, and content of hydrogen peroxide and non-peroxide components and royal jelly because of Royalisin protein, fatty acid Trans-10-Hydroxy-2- Decenoic acid (10-HAD) and Jelleins peptides; they have a wide spectrum of antibacterial activity. In this study, anti-Helicobacter pylori property of thyme honey and Royal Jelly, harvested from hive located in Damavand region near Tehran-Iran, and mixture of them, against the standard strain of H.pylori ATCC 43504, was evaluated by Minimum Inhibitory Concentration (MIC) method. This method as the golden standard technique for determining the sensitivity of microorganisms to antimicrobial agents has been known and in accordance with standard procedures in the British Society For Antimicrobial Chemotherapy (BSAC) guidelines, was performed. Thyme honey and Royal Jelly and their mixture with positive control sample as cephalexin, had respectively 31.25, 62.5, 31.25, 0.0652 mg/ml MIC against standard strain of H. pylori. There was no synergy effect between honey and Royal Jelly in this study. Manuscript profile -
Open Access Article
10 - Effect of in ovo Injection of Royal Jelly on Post-Hatch Growth Performance and Immune Response in Broiler Chickens Challenged with Newcastle Disease Virus
Y. Jafari Ahangari S.R. Hashemi A. Akhlaghi H. Atashi Z. Esmaili M. Ghorbani R. Mastani A. Azadegan H. Davoodi -
Open Access Article
11 - اثر تزریق داخل تخم مرغ ژل رویال بر جوجه درآوری، کیفیت جوجههای یکروزه، عملکرد و بعضی ویژگیهای ایمنی در جوجههای تازه تفریخ شده
م. گوهری ح.ر. خدائی م. طغیانیبه منظور بررسی اثر تزرق داخل تخم مرغ سطوح متفاوت ژل رویال بر میزان جوجه درآوری و کیفیت جوجههای یکروزه (راس 308) و بعضی ویژگیهای سیستم ایمنی آنها آزمایشی انجام شد. 640 تخم در قالب طرح کاملاً تصادفی به چهار سطح تزریق ژل رویال شامل: 1) یک میلیلیتر سرم فیزیولوژی (کنترل)، Moreبه منظور بررسی اثر تزرق داخل تخم مرغ سطوح متفاوت ژل رویال بر میزان جوجه درآوری و کیفیت جوجههای یکروزه (راس 308) و بعضی ویژگیهای سیستم ایمنی آنها آزمایشی انجام شد. 640 تخم در قالب طرح کاملاً تصادفی به چهار سطح تزریق ژل رویال شامل: 1) یک میلیلیتر سرم فیزیولوژی (کنترل)، 2) 5/0 میلیگرم ژل رویال، 3) 75/0 میلیگرم ژل رویال، 4) یک میلیگرم ژل رویال اختصاص داده شدند. برای هر تیمار، چهار تکرار در نظر گرفته شد و 40 تخم در هر تکرار استفاده شد. در روز 14 انکوباسیون، محلول آزمایشی با استفاده از سرنگ انسولین با سوزنی به طول 2 سانتیمتر داخل محلول آلانتوئیک تزریق شد. بعد از 510 ساعت انکوباسیون، همه جوجههای هچ شده به خوب، متوسط و ضعیف دستهبندی شدند. شاخصهای مورد مطالعه در طول دوره پرورش شامل افزایش وزن، مصرف خوراک، ضریب تبدیل غذایی و ویژگیهای سیستم ایمنی بود. تزریق ژل رویال تفاوتی در سرعت تفریخ ایجاد نکرد، اما کیفیت جوجههای یکروزه را به طور معنیداری افزایش داد (05/0>P). علاوه بر این، افزایش وزن، مصرف خوراک و ضریب تبدیل غذایی در مقایسه با گروه کنترل به طور معنیداری بهبود یافت. تیتر آنتیبادی تحت تأثیر تیمارهای آزمایشی قرار نگرفت، اما در نتیجه تزریق ژل رویال افزایش یافت. براساس عملکرد جوجهها در دوره پرورش، میتوان نتیجه گرفت که بهترین عملکرد و پاسخ ایمنی در جوجههای تفریخ شده با تزریق 5/0 میلیلیتر ژل رویال به دست آمد. Manuscript profile -
Open Access Article
12 - Protective Effect of Royal Jelly on Methotrexate Infertility in Female Rats
Atikeh Amindoost Mona Farhadi Parvin Torabzadeh -
Open Access Article
13 - Protective Effect of Royal Jelly on Methotrexate Infertility in Female Mice
Hossein Bakhoda Nematollah Nemati Tahereh BagherpoorMethotrexate is a chemotherapy drug that is widely used in neoplastic disorders and ectopic pregnancy. In previous research, the toxicity of methotrexate has been reported on the genital tract. The properties of Royal jelly such as impotence improvement, and antioxidant MoreMethotrexate is a chemotherapy drug that is widely used in neoplastic disorders and ectopic pregnancy. In previous research, the toxicity of methotrexate has been reported on the genital tract. The properties of Royal jelly such as impotence improvement, and antioxidant and anticancer function have been reported. Therefore, in the present research, the effect of Royal jelly on ovarian cells in NMRI female mice treated with methotrexate was investigated. In this study, 70 female mice were divided into: negative control (without injection), positive control (received 0.5 mg/kg methotrexate), sham, and three experimental groups (T1, T2, and T3 received methotrexate plus 25, 50 and 100 mg/kg Royal jelly). Intraperitoneal injection was performed for 8 days. After histological processing and staining, the ovarian tissue, primary, secondary and graafian follicles, yellow body, as well the number of generation was investigated. Data were analyzed by Tukey test and one way ANOVA. Results showed there was a significant decrease in the number of generation in positive control, but the number of generation in experimental groups returned to the initial state. Regarding the duration of fertility, there was a significant decrease in the fertility rate in T1 and T3 compared to positive control group. The results of estrogen hormone showed a significant decrease in positive control group compared to negative control and increased significantly in T1 and T2. The number of primary, secondary, and graafian follicles in T 2 and T3 showed a significant increase (P<0.001). According to the present study, it was found that with further investigations, the appropriate dose of Royal jelly could act as a protective agent against the side effects of methotrexate and improve fertility. Manuscript profile -
Open Access Article
14 - The Effect of Eight Weeks of Endurance Training on Positive and Negative Gradients with Royal Jelly on Hippocampal Concentration of Carbonyl Protein and Pain Tolerance Threshold of Trimethylettin-treated Alzheimer’s Rats
Hamid Mousazadeh Nematollah Nemati Tahereh BagherpoorIncreased oxidative stress causes neuronal damage and incidence of chronic pains in patients with Alzheimer’s disease (AD). The aim of this study was to investigate the effect of eight weeks of endurance exercises in positive (PST) and negative (NST) slope with ro MoreIncreased oxidative stress causes neuronal damage and incidence of chronic pains in patients with Alzheimer’s disease (AD). The aim of this study was to investigate the effect of eight weeks of endurance exercises in positive (PST) and negative (NST) slope with royal jelly (RJ) on the hippocampal concentration of protein-carbonyl (PC) and pain tolerance threshold (PT) of Alzheimer’s rats with trimethyltin (TMT). In this experimental study, 49 Alzheimer’s rats with intraperitoneal injection of 8 mg/kg neurotoxin TMT were randomly divided into seven groups :(1) AD, (2) sham (normal saline) (Sh), (3) PST, (4) NST, (5) PST + RJ, (6) NST + RJ, and (7) RJ. To investigate the effect of Alzheimer’s disease on research variables, seven rats were included in the healthy control group (C). PST (with the speed of 16 m/min at positive slope (+15%)) and NST (with the speed of 16 m/min at negative slope (-15%)) interventions were carried out for eight weeks, five sessions per week and 60 minutes per session. RJ (dissolved in normal saline) was intraperitoneally consumed for eight weeks at 100 mg/kg /day. One-way ANOVA test along with Tukey post-hoc test were used in SPSS 22 software to investigate the intergroup difference (P ≤0.05). NST caused to decrease hippocampal level of PC (P = 0.001) and PT, as well as PST caused to decrease PT (P = 0.001). NST + RJ caused to decrease the hippocampal levels of PC (P = 0.001) and PT (P = 0.001) in rats with Alzheimer’s disease. Moreover, PT significantly reduced in the PST + RJ group (P = 0.001). PC hippocampal levels in the NST + RJ group were lower than in the PST + RJ group (P = 0.001). It seems that NST alone and with RJ have analgesic (anti-pain) and oxidative stress reduce effects. Although the interaction of PST and RJ had analgesic effects, the need of more studies on oxidative stress reducing effects is felt following PST and RJ consumption. Manuscript profile -
Open Access Article
15 - The Interactive Effect of Running on Different Slopes with the Use of Royal Jelly on the Concentration of Some Antioxidants in an Animal Model of Trimethyltin-treated Alzheimer’s
Hamid Mousazadeh Nematollah Nemati Tahereh BagherpoorAlthough the role of exercise and royal jelly in the health of Alzheimer’s patients has been reported, the interaction effect of these two variables on superoxide dismutase (SOD) and glutathione peroxidase (GPx) is still not well understood. Therefore, the present MoreAlthough the role of exercise and royal jelly in the health of Alzheimer’s patients has been reported, the interaction effect of these two variables on superoxide dismutase (SOD) and glutathione peroxidase (GPx) is still not well understood. Therefore, the present study was aimed at investigating the interactive effect of positive slope running (PSR) and negative slope running (NSR) with royal jelly on SOD and GPx concentrations in a trimethyltin (TMT) Alzheimer’s animal model. In this experimental trial, 49 rats in the age range of 8-10 weeks, weighing 190-220 g, Alzheimer’s with 8 mg/kg TMT were assigned into seven groups including group one: TMT, group two: sham, group three: Royal jelly, group four: positive slope, group five: negative slope, group six: royal jelly + positive slope and group seven: Royal jelly + negative slope. Moreover, to investigate the effect of Alzheimer’s induction on the research variables, seven healthy rats were included in the healthy control group following the positive slope and negative slope exercises for eight weeks, three sessions per week and each session ran for 60 minutes on a positive 15 and negative 15 slope on the treadmill. Besides, 100 mg/kg of royal jelly was peripherally injected into rats daily. One-way analysis of variance (ANOVA) with Tukey post hoc test and two-way ANOVA with Bonferroni post hoc test in SPSS 22 software were used to analyze the data (p ≤ 0.05). Negative slope increased SOD and GPx in hippocampal tissue of AD rats. PSR and royal jelly increased GPx. Positive slope and royal jelly and negative slope and royal jelly groups had a significant effect on increasing SOD and GPx. Positive and negative slopes and royal jelly seem to improve antioxidant defense; furthermore, the interaction of positive slope and royal jelly and the interaction of negative slope and royal jelly are more desirable than the effect of each alone. Manuscript profile
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