The effecte of eight weeks of resistance training with royal jelly on the pathaphysiological changes in the hippocampal tissue of Alzheimer's rats
Subject Areas : Effect of Physical Activity on Diseases
Leila Mokhtari
1
,
Tahereh Bagherpour
2
,
Nematollah Nemati
3
1 - Department of Sports Physiology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Sports Physiology ,Damghan Branch,Islamic Azad Unversity ,Damghan,Iran.
3 - Department of Sports Physiology,Damghan Branch ,Isamic Azad Univesity ,Damghan
Keywords: Exercise, Royal Jelly, Oxidative Stress, Hippocampus, Alzheimer', s disease,
Abstract :
Abstract Introduction: Oxidative stress plays role in the progression of Alzheimer's disease (AD).exercise and antioxidants on neuronal health have effect . the effect of eight weeks of resistance training (RT) along with royal jelly (RJ) on Malondialdehyde (MDA), Protein Carbonylate (PC) and the pathological changes in the hippocampal tissue of Alzheimer's rats treated with trimethyltin (TMT)has been determined. Methods: In this experimental study, 42 male Sprague-Dawley rats treated with 8 mg/kg TMT were divided into TMT, Sham, RJ100, RJ200, RT, RT+RJ100 and RT+RJ200 groups. Supplemental groups received RJ with doses of 100 and 200 mg/kg/day as peritoneal injection, and the increasing RT protocol was performed for 8 weeks, 3 sessions a week with an intensity of 30 to 100% of the weight. Results: MDA, PC in TMT group were significantly higher than HC group. But MDA and PC in RT+RJ200 group were lower than TMT group (P≤0.05). Also, PC in RT group was significantly lower than TMT. MDA in RJ200 group were lower than TMT; PC values in RJ100 group was significantly lower than TMT (P≤0.05). The reducing effect of PC in RJ100 group was more favorable than RJ200 (P≤0.05). Also, the effect of reducing MDA in the RT+RJ200 group was more favorable than the RT+RJ100 group (P≤0.05). Conclusion:the resistance training and royal jelly have favorable effects on reducing oxidative stress. the simultaneous effect of these two interventions, especially with a higher dose, has a more favorable effect on reducing oxidative stress in the hippocampus tissue in AD modeling conditions.
