List of Articles Hippocampus

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  1 - The effecte of eight weeks of resistance training with royal jelly on the pathaphysiological changes in the hippocampal tissue of Alzheimer's rats
  Leila Mokhtari Tahereh Bagherpour Nematollah Nemati
  Abstract Introduction: Oxidative stress plays role in the progression of Alzheimer's disease (AD).exercise and antioxidants on neuronal health have effect . the effect of eight weeks of resistance training (RT) along with royal jelly (RJ) on Malondialdehyde (MDA) More

  Abstract Introduction: Oxidative stress plays role in the progression of Alzheimer's disease (AD).exercise and antioxidants on neuronal health have effect . the effect of eight weeks of resistance training (RT) along with royal jelly (RJ) on Malondialdehyde (MDA), Protein Carbonylate (PC) and the pathological changes in the hippocampal tissue of Alzheimer's rats treated with trimethyltin (TMT)has been determined. Methods: In this experimental study, 42 male Sprague-Dawley rats treated with 8 mg/kg TMT were divided into TMT, Sham, RJ100, RJ200, RT, RT+RJ100 and RT+RJ200 groups. Supplemental groups received RJ with doses of 100 and 200 mg/kg/day as peritoneal injection, and the increasing RT protocol was performed for 8 weeks, 3 sessions a week with an intensity of 30 to 100% of the weight. Results: MDA, PC in TMT group were significantly higher than HC group. But MDA and PC in RT+RJ200 group were lower than TMT group (P≤0.05). Also, PC in RT group was significantly lower than TMT. MDA in RJ200 group were lower than TMT; PC values in RJ100 group was significantly lower than TMT (P≤0.05). The reducing effect of PC in RJ100 group was more favorable than RJ200 (P≤0.05). Also, the effect of reducing MDA in the RT+RJ200 group was more favorable than the RT+RJ100 group (P≤0.05). Conclusion:the resistance training and royal jelly have favorable effects on reducing oxidative stress. the simultaneous effect of these two interventions, especially with a higher dose, has a more favorable effect on reducing oxidative stress in the hippocampus tissue in AD modeling conditions. Manuscript profile
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  2 - The Influence of L-arginine in the Improving Effect of Nicotine on Ethanol-induced Amnesia
  مرتضی پیری اعظم مشفق نسرین رئوفی مریم السادات شاهین
  Nitric oxide synthase has been detected in dorsal hippocampus, which is a key brain region that seems mediate behavioral effect of ethanol and nicotine. In the present study, the effects of L-arginine, a nitric oxide precursor, in the dorsal hippocampus in nicotineandrs More

  Nitric oxide synthase has been detected in dorsal hippocampus, which is a key brain region that seems mediate behavioral effect of ethanol and nicotine. In the present study, the effects of L-arginine, a nitric oxide precursor, in the dorsal hippocampus in nicotineandrsquo;s effect on ethanol-induced amnesia was investigated.This experimental study was performed on 300 male mice. Mice were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus, trained in a step-down type inhibitory avoidance task, and tested 24 h after training to measure step-down latency. Pre-training or pre-test injection of ethanol (1 g/kg) decreased the memory retrieval. Injection of nicotine or L-arginine before test by itself has no effect on memory retrieval. On the other hand, pre-test administration of ethanol (0.5, 1 g/kg), nicotine (0.4, 0.8 andmicro;g/mice) or L-arginine (0.8 andmicro;g/mice) plus non-effective dose of nicotine (0.2 andmicro;g/mice) restored memory impairment induced by pre-training injection of ethanol. These results suggest that nitric oxide system of dorsal hippocampus may play an important role in the improving effect of nicotine on the ethanol-induced amnesia. Manuscript profile
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  3 - Influence of Dopamine D2 Receptors of the Dorsal Hippocampus in the Improving Effect of Nicotine on Ethanol-induced Amnesia
  مریم‌السادات شاهین سیما نصری مرتضی پیری
  Ethanol and nicotine produce some effects via activation of mesocorticolimbic dopaminergic pathway which projects from the ventral tegmental area to the nucleus accumbens and hippocampus. Dopamine D2 receptors have been detected in dorsal hippocampus, which is a key bra More

  Ethanol and nicotine produce some effects via activation of mesocorticolimbic dopaminergic pathway which projects from the ventral tegmental area to the nucleus accumbens and hippocampus. Dopamine D2 receptors have been detected in dorsal hippocampus, which is a key brain region that influences learning and memory. In the present study, influence of dopamine D2 receptors of dorsal hippocampus in nicotineandrsquo;s effect on ethanol-induced amnesia was investigated. In this experimental study 255 adult male NMRI mice were used (24 group). The animals anaesthetized and cannulae implanted bilaterally in the CA1 regions of the dorsal hippocampus using stereotaxic method. Seven days after recovery from surgery, the behavioral testing was started in inhibitory avoidance task. In this study ethanol, nicotine and sulpiride (D2 receptor agonist) were used. The Kruskalandndash;Wallis nonparametric one-way analysis of variance (ANOVA) followed by a two-tailed Mannandndash;Whitneyand#39;s U-test, were used for analysis of the data. Differences with P andlt; 0.05 between experimental groups at each point were considered statistically significant. Pre-training or pre-test injection of ethanol induced amnesia (Pandlt;0.001). Pre-test administration of ethanol or nicotine restored amnesia ethanol (Pandlt;0.001). Pre-test intra-CA1 injection of sulpirideblocks the nicotine reversal effect on ethanol amnesia (Pandlt;0.001).On the other hand, pre-test injection of nicotine or sulpiride has no effect on memory by itself (Pandgt;0.05). Our results in this study indicated that the blockage of dopamine d1 receptors of dorsal hippocampus decreases nicotine-induced restoration of ethanol amnesia. Manuscript profile
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  4 - Nicotinic and NMDA Receptors Interaction in the Dorsal Hippocampus of Rats in the Elevated Plus-Maze Test of Anxiety
  مرتضی پیری محمد ناصحی مریم السادات شاهین
  Nicotinic and glutamatergic receptors have role on anxiety-like behavior. But determination site of action for these receptors in the brain needs to be investigated. Therefore, in this study, we investigated the possible involvement of nicotinic and glutamatergic recept More

  Nicotinic and glutamatergic receptors have role on anxiety-like behavior. But determination site of action for these receptors in the brain needs to be investigated. Therefore, in this study, we investigated the possible involvement of nicotinic and glutamatergic receptors in the dorsal hippocampus on anxiety- like behavior. The male Wistar rats were placed in a stereotaxic apparatus. Two stainless-steel cannuale were placed in the CA1 region of hippocampus. Then, anxiety-like behaviors of animals has been measured using the elevated plus-maze. Our results shown that intra-CA1 administration of MK801 (2 andmicro;g/rat) and mecamylamine (2 andmicro;g/rat) by itself, increased percentage of open arm time and open arm entries but did not alter locomotion. On the other hand, intra-CA1 co-administration of ineffective doses of mecamylamine (0.5, 1 andmicro;g/rat) with ineffective dose of MK801 (1 andmicro;g/rat) did not any significant effect on anxiety-like behavior and locomotion activity. Although both NMDA and nicotinic receptors play important role in the modulation of anxiety in the dorsal hippocampus of rats but between these receptors have no interaction on anxiety-like behavior in this site. Manuscript profile
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  5 - Effects of α1- and α2-adrenoceptor agonist and antagonist in the dorsal hippocampus on cannabinoid state-dependent memory
  اعظم مشفق پروین بابایی مرتضی پیری شهربانو عریان بهرام سلطانی محمدرضا زرین دست
  Cannabinoids are a class of psychoactive compound that produce a wide range of effects in different number of species. The present study evaluated the possible role of andalpha;1- and andalpha;2-adrenergic receptors of the dorsal hippocampus on cannabinoid induced amnes More

  Cannabinoids are a class of psychoactive compound that produce a wide range of effects in different number of species. The present study evaluated the possible role of andalpha;1- and andalpha;2-adrenergic receptors of the dorsal hippocampus on cannabinoid induced amnesia and cannabinoid state-dependent memory in adult male Wistar rats. The animals were bilaterally implanted with chronic cannulae in the CA1 regions of the dorsal hippocampus, trained in a step-down type inhibitory avoidance task, and tested 24h after training to measure step-down latency. Post-training intra-CA1 injection of cannabinoid receptors agonist, WIN55,212-2 (0.25 and 0.5 andmicro;g/rat) induced amnesia. Amnesia induced by post-training WIN55,212-2 (0.5 andmicro;g/rat) was restored by pre-test administration of the same dose of WIN55,212-2. Pre-test intra-CA1 injection of phenylephrine could not affect memory but clonidine improved memory impairment induced by WIN55,212-2. Furthermore, microinjection of phenylephrine or clonidine plus an ineffective dose of WIN55,212-2, synergistically restored amnesia induced by WIN55,212-2 . On the other hand, pre-test intra CA1 microinjection of prazosin or yohimbine 2 min before WIN55,212- inhibited pre-test WIN55,212-2 response. These results indicate that andalpha;-adrenergic receptors of the dorsal hippocampal CA1 regions may play an important role in cannabinoid-induced amnesia and cannabinoid state-dependent memory. Manuscript profile
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  6 - Effect of cannabinoidergic drugs in the dorsal hippocampus of morphine sensitized rats in the memory formation.
  مجید نوائیان بهاره پاکپور محمدرضا زرین دست شهربانو عریان
  In present study, the effects of intra-dorsal hippocampal (intra-CA1) injection of cannabinoid receptor agents on memory formation have been investigated in 3-days morphine-treated rats. Method: Passive avoidance task of memory has been used to examine for retrieval of More

  In present study, the effects of intra-dorsal hippocampal (intra-CA1) injection of cannabinoid receptor agents on memory formation have been investigated in 3-days morphine-treated rats. Method: Passive avoidance task of memory has been used to examine for retrieval of memory formation, 24 h after training. morphine was injected subcutaneously (S.C.), once daily for 3-days followed by 5 days free of the morphine before training. Results: Post-training intraandndash;CA1 administration of cannabinoid receptor agonist, WIN55, 212-2 (0.25 and 0.5 andmicro;g/rat) and CB1 receptor antagonist, AM251 (25 and 50 ng/rat, intraandndash;CA1) decreased memory retrieval. Administration of AM251 (25, 50 and 100 ng/rat, intra andndash; CA1), 2 min before injection of effective dose of WIN55, 212-2 (0.5 andmicro;g/rat) decreased the response induced by WIN55, 212-2. Repeated administration of different doses of morphine (2.5, 5 and 10 mg /kg) for 3-days incraesed memory retrieval. However, repeated administration of different doses of morphine (2.5, 5 and 10 mg /kg) for 3-days reversed amnesia induced by WIN55, 212-2. Conclusion: The results suggest that cannabinoidergic and opioidegic system have a close interaction on memory retrieval and WIN55,212-2 influence on memory formation and subchronic morphine pre-treatment may restore memory through a possible opioidergic receptor sensitization. Manuscript profile
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  7 - The Inhibition of State-Dependent Learning Induced By Scopolamine Via Blockade of Dorsal Hippocampal Beta1-Adrenergic Receptors in Rats
  بهاره پاکپور مجید نوائیان مرتضی پیری
  Adrenergic and cholinergic systems of the brain play an important role in learning and memory. Previous studies indicate that scopolamine impair inhibitory avoidance memory and induce state-dependent learning. In the present study, the effects of andbeta;1-adrenoceptor More

  Adrenergic and cholinergic systems of the brain play an important role in learning and memory. Previous studies indicate that scopolamine impair inhibitory avoidance memory and induce state-dependent learning. In the present study, the effects of andbeta;1-adrenoceptor antagonist on scopolamine state-dependent learning were examined in rat dorsal hippocampus. In this experimental study 155 adult male rats were anaesthetized and cannulae implanted bilaterally in the CA1 regions of the dorsal hippocampus using stereotaxic method. Seven days after recovery from surgery, the behavioral testing was started in inhibitory avoidance task. In this study Scopolamine as muscarininc receptor antagonist and atenolol as andbeta;1-adrenergic receptor antagonist were used. Pre-training intra-CA1 injection of scopolamine (1.5 and 3 andmicro;g/rat) impaired inhibitory avoidance memory. Amnesia produced by pre-training scopolamine was reversed by pre-test administration of the same dose of scopolamine that is due to a state-dependent effect. Pre-test intra-CA1 injection of atenolol (0.09 andmu;g/rat) also impaired inhibitory avoidance memory.Furthermore, pre-test injection of atenolol (0.09 andmu;g/rat) 2 min before the administration of scopolamine inhibited scopolamine state-dependent memory.It can be concluded that the andbeta;1-adrenergic receptors of dorsal hippocampus may play animportant role in scopolamine state-dependent learning Manuscript profile
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  8 - Modulated Effect of Dorsal Hippocampus (CA1) Antagonist of 5HT4 upon ACPA Induced Amnesia in Mice vر
  مریم فرهی زاده محمدرضا زرین دست محمد ناصحی مریم بنانج
  The aim of present study is investigates the effects of bilateral injection of dorsal hippocampal (CA1) serotonergic system (Antagonist of 5-HT4) in fear memory formation process induced by ACPA (Arachidonylcyclopropylamide). Male NMRI mice were used in our experiments. More

  The aim of present study is investigates the effects of bilateral injection of dorsal hippocampal (CA1) serotonergic system (Antagonist of 5-HT4) in fear memory formation process induced by ACPA (Arachidonylcyclopropylamide). Male NMRI mice were used in our experiments. Fear conditioning task was used for conditioning of fear. 24 hours after train we estimated the fear memory formation. The data show that intra peritoneal administration of ACPA (0.005, 0.05 and 0.5 mg/kg) causes impairment of fear memory and amnesia. Moreover, intra-CA1 injection of 5-HT4 receptor antagonist, (RS23597-190) (0.01, 0.1 and 0.2 µg/mice) had no effect on fear memory in saline-treated mice but restored the impairment of fear memory in ACPA-treated mice. The data strongly showed that serotonergic system (Antagonist) in the CA1 of hippocampus induced by ACPA interferes in impairment of fear memory. Manuscript profile
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  9 - The Inhibition of State-Dependent Learning Induced By Scopolamine Via Blockade of Dorsal Hippocampal Beta1-Adrenergic Receptors in Rats
  بهاره پاکپور مجید نوائیان مرتضی پیری
  Adrenergic and cholinergic systems of the brain play an important role in learning and memory. Previous studies indicate that scopolamine impair inhibitory avoidance memory and induce state-dependent learning. In the present study, the effects of andbeta;1-adrenoceptor More

  Adrenergic and cholinergic systems of the brain play an important role in learning and memory. Previous studies indicate that scopolamine impair inhibitory avoidance memory and induce state-dependent learning. In the present study, the effects of andbeta;1-adrenoceptor antagonist on scopolamine state-dependent learning were examined in rat dorsal hippocampus. In this experimental study 155 adult male rats were anaesthetized and cannulae implanted bilaterally in the CA1 regions of the dorsal hippocampus using stereotaxic method. Seven days after recovery from surgery, the behavioral testing was started in inhibitory avoidance task. In this study Scopolamine as muscarininc receptor antagonist and atenolol as andbeta;1-adrenergic receptor antagonist were used. Pre-training intra-CA1 injection of scopolamine (1.5 and 3 andmicro;g/rat) impaired inhibitory avoidance memory. Amnesia produced by pre-training scopolamine was reversed by pre-test administration of the same dose of scopolamine that is due to a state-dependent effect. Pre-test intra-CA1 injection of atenolol (0.09 andmu;g/rat) also impaired inhibitory avoidance memory.Furthermore, pre-test injection of atenolol (0.09 andmu;g/rat) 2 min before the administration of scopolamine inhibited scopolamine state-dependent memory.It can be concluded that the andbeta;1-adrenergic receptors of dorsal hippocampus may play animportant role in scopolamine state-dependent learning. Manuscript profile
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  10 - The Effect of Risperidone on the Induction of Psychological Dependence and the Number of Hippocampal Neurons in Adult Male Rats
  Zahra Mansouriarani Nasrin Heydariyeh Hamid Reza Banafshe Gholamreza Ghavipanjeh Majid Lotfinia
  10.22034/ascij.2023.1964676.1410
  Psychological dependence on substances is the desire to consume substances or something that has pleasurable effects and produces satisfaction. Various substances cause this dependence. Previous studies indicate the possible effect of risperidone on the brain reward sys More

  Psychological dependence on substances is the desire to consume substances or something that has pleasurable effects and produces satisfaction. Various substances cause this dependence. Previous studies indicate the possible effect of risperidone on the brain reward system and the involvement of different receptors in conditioned place preference (CPP). Therefore, the present study was designed with the aim of investigating the effect of risperidone on the induction of psychological dependence and the number of hippocampal neurons. For this study, 40 male Wistar rats with a weight range of 230-280 grams were used. Risperidone was injected intraperitoneally with doses of 1, 2 and 4 mg/kg. At the end of the hippocampus experiments, the animals were taken out and fixed by formalin, then cut and after staining, they were used for histological evaluation and neuronal counting. The results of this study showed that the administration of risperidone with a dose of 2 and 4 mg/kg causes a significant increase in CPP (p < 0.05). Also, in histological evaluation, no neuronal destruction was observed in all risperidone groups (1, 2 and 4 mg/kg). According to the obtained results, it can be concluded that risperidone in higher doses causes an increase in conditioned place preference and learning and dependence and should be considered in treatment. Manuscript profile