The effect of three months of interval aerobic training and Quercetin supplementation on the concentration Bax and Bcl-2 in the hippocampus of male Parkinson's model rats
Subject Areas : Experimental physiology and pathology
Sirous Kianmehr
1
,
Jabbar Bashiri
2
,
Roghayeh Pouzesh Jadidi
3
,
Hasan pourrazi
4
,
mir Alireza norazar
5
1 - Department of Sports Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
2 - Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
3 - Department of Physical Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
4 - Qazvin Azad University Science
5 - Faculty of Veterinary Medicine, Department of Basic Sciences, Tabriz Medical Sciences Unit, Islamic Azad University, Tabriz, Iran.
Keywords: interval aerobic exercise, quercetin, hippocampus, Bax, Bcl-2,
Abstract :
Background & purpose: Parkinson's disease is a progressive neurological disorder caused by the death of neurons in the substantia nigra, the degeneration of dopaminergic neurotransmission, and the presence of alpha-synuclein and protein components in the cell body of neurons. The purpose of this research was to explain the effect of three months of interval aerobic exercise and quercetin supplementation on the concentration Bax and Bcl-2 in the hippocampus of male Parkinsonian model rats.
Materials & Method: To conduct the present experimental research, 28 male Wistar rats were prepared and divided into 5 healthy control groups, 5 Parkinson's control groups, 6 Parkinson's training groups, 6 Parkinson's melatonin groups, and 6 Parkinson's training + Parkinson's supplement groups. were divided Then, the training groups performed the interval training program for 12 weeks and consumed 100 mg/kg of quercetin daily. Finally, after the last training session, the hippocampus tissue was removed and the research variables were measured using the Bradford method.
Results: The results showed the significant effects of training and the lack of significant effects of training and supplementation on Bax. Also, the results of the significant effects of exercise and exercise and supplementation and the lack of significant effect of supplementation on bcl-2 are significant. But the main effect of quercetin supplementation has been shown on bcl-2.
Conclusion: According to the results, the use of exercise and exercise and quercetin supplement is recommended for diabetics under the supervision of a specialist
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