List of Articles Inhibitory effect

• Open Access Article
  • Abstract Page
  • Full-Text
  
  1 - The inhibitory effect of garlic (Allium sativum L.) essential oil nanoliposomes on Shiga-toxin 2 expression in Escherichia coli O157:H7
  Ali Zabihi Afshin Akhondzadeh basti Ghasem Amoabediny Akram Tabatabaee Bafroee Ali Khanjari Javad Tavakkoly Bazzaz
  Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  2 - Quantitative structure–activity relationship study for predicting activity of some medicine compounds by firefly algorithm
  mehdi nekoei Fatemeh Shams
  Quantitative structure–activity relationship models were developed for predicting activity of a series of medicine compounds such as pyridine derivatives. The suitable set of the molecular descriptors was calculated and the important descriptors using the variable More

  Quantitative structure–activity relationship models were developed for predicting activity of a series of medicine compounds such as pyridine derivatives. The suitable set of the molecular descriptors was calculated and the important descriptors using the variable selections of the stepwise (SW) and the firefly algorithm (FFA) were selected. The predictive quality of the QSAR models was tested for an external set of compounds by multiple linear regression (MLR). Statistical parameters for SW-MLR and FF-MLR were R2 train = 0.835, 0.859, RMSEP = 0.620, 0.786, REP= 10.72, 10.52 respectively. A comparison between the attained results indicated the superiority of the firefly algorithm over the stepwise method in the feature selection. The predicted results of this study can be used to design new inhibitors of melanoma anti-cancer. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  3 - Antimicrobial effects of extracellular copper sulfide nanoparticles synthesized from Bacillus licheniformis
  Morahem Ashengroph Maryam Sahami-Soltani
  Background & Objectives: Copper nanoparticles due to unique catalytic properties and electrical and optical conductivity are of great importance. This study was aimed to use the potential of aquatic bacteria as biocatalysts to reduce copper sulfate into copper sulfi More

  Background & Objectives: Copper nanoparticles due to unique catalytic properties and electrical and optical conductivity are of great importance. This study was aimed to use the potential of aquatic bacteria as biocatalysts to reduce copper sulfate into copper sulfide nanoparticles (CuSNPs) and to assess its antimicrobial properties.Materials & Methods: The CuSNPs produced via bioconversion reaction have been characterized by spectroscopy analysis, electro-micrographs prepared by scanning electron microscopy (SEM) and particle size distribution histogram. The antimicrobial activity of CuSNPs against some bacteria and pathogenic fungi was also investigated by disc diffusion test.Results: 105 Cu-resistant bacterial strains have been isolated according to selective enrichment technique. Based on the results, the only culture supernatant of strain Cu25 was able to reduce copper sulfate into copper sulfide nanoparticles (CuSNPs), extracellular. The cu25 strain was identified as Bacillus licheniformis based on phenotypic and molecular analysis. Subsequently, the extracellular synthesis of CuSNPs was investigated.  The results showed that the supernatant of B. licheniformis Cu25 following exposure to 7.5 mM copper sulfate solution and 24 h of incubation can produce spherical CuSNPs with the average diameter of 21.5 nm as extracellular.Conclusion: The current study is the first report on the extracellular synthesis of CuSNPs using B. licheniformis. Also, the produced biological nanoparticles have growth inhibitory effect against some pathogenic bacteria and fungi. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  4 - Isolation and identification of Lactic Acid Bacteria in the people's mouth and studying on their inhibitory effect on some entropathogenic bacteria
  Jamileh Noroozi Anita Khanafari Shirin Beiglari
  Background and objectives: Predominant organisms in plaques are of the genus Streptococcus, with Streptococcus mutans being the species most important in the formation of dental caries. Another organism that is important in the development of caries is the lactobacillus More

  Background and objectives: Predominant organisms in plaques are of the genus Streptococcus, with Streptococcus mutans being the species most important in the formation of dental caries. Another organism that is important in the development of caries is the lactobacillus. Lactobacillus species are not important in the initiation of caries but in the continuation. The aim of this study was to isolate and identify of lactic acid bacteria from the mouth in different ages, determination of pH and study the inhibitory effect of isolated Lactobacilli on some entropathogens bacteria (Salmonella, Shigella and Escherchia coli). Material and Methods: From 75 persons in different ages, the samples were collected from saliva and around dental and were cultured in MRS medium. Lactobacilli and Streptococci were isolated and identified by standard methods (morphology, microscopic shape and chemical characteristics and fermentation of carbohydrates). Growth pH of isolated Lactobacillus was determined. Inhibitory effects of isolated bacteria were evaluated by spot on the lawn, blank disk and well-diffusion methods on Salmonella, Shigella and Escherichia coli. Results: Isolated Lactobacillus were including L. fermentum, L. casei, L. gasseri, L. brevis, L. plantarum and L. acidophilus, and isolated Streptococci was Streptococcus mutans. Isolated Lactobacilli had inhibitory effect on Escherichia coli but they didn't have any inhibitory effect on Salmonella and Shigella. Conclusion: Our results showed that some Lactobacilli had inhibitory effect on some pathogenic in vitro. So, consumption of dairy (because of the presence of Lactobacilli) is recommended. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  5 - Cytotoxicity Effects of Ammi visnaga Extract on Hela and MCF7 Cancer Cell Line vvررررررررررررررر
  هدیه پاک فطرت فرخنده نعمتی عبدالحسین شیروی
  The discovery of new materials such as anti-microbial and anti-viral and anti-cancer known among plants or those who have recently been discovered can help to treat diseases. In this study, the cytotoxic effect of plant extracts Ammi visnaga extract on Hela and MCF7 cel More

  The discovery of new materials such as anti-microbial and anti-viral and anti-cancer known among plants or those who have recently been discovered can help to treat diseases. In this study, the cytotoxic effect of plant extracts Ammi visnaga extract on Hela and MCF7 cell lines were analyzed. Different concentrations of ethanolic extract of the Ammi visnaga on cultured blood cells and cancer cell line for 72 hours were examined. The cytotoxicity was evaluated by MTT test. Results are reported as IC50. This study showed that different concentrations of Ammi visnaga extract have cytotoxic effect on Hela and MCF7 cell lines. The percentage of growth inhibition of Hela and MCF7 cells increasing whit whit increasing concentration of test compounds. IC50 value for Hela was 0.57 mg /ml, and for MCF7 was 2mg/ml. The results suggest that ethanolic extract of Ammi visnaga has inhibitory effect on cell growth of MCF7 and Hela cell lines. vv Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  6 - The inhibitory effect of mistletoe extract on the growth and sporulation of Aspergillus flavus in laboratory conditions
  Siamak Salahi
  10.22034/aej.2021.708296
  Nearly 20 to 45 percent of the world's grains were exposed to mycotoxins produced by the fungus. Aspergillus flavus is one of the fungi that cause widespread contamination of crops and warehouse products. In this research, the antifungal activity of different extracts o More

  Nearly 20 to 45 percent of the world's grains were exposed to mycotoxins produced by the fungus. Aspergillus flavus is one of the fungi that cause widespread contamination of crops and warehouse products. In this research, the antifungal activity of different extracts of the semi-parasitic mistletoe (Viscum album) plant on the growth and sporulation of Aspergillus flavus in laboratory conditions based on completely random design with three replications was evaluated. Various solvents including acetone, ethanol, methanol and water were used to extract mistletoe leaves and buds. Antifungal activity of the extracts was performed by diffusion method on the surface of agar. Each of the extracts including 0 (control), 2, 20, 200 and 2000 microliters per 20 milliliters were added to medium and colony growth and sporulation of fungi were evaluated. All experimental treatments showed a significant effect on mycelium growth and sporulation of Aspergillus flavus compared to control at 5% level. Methanol extract in 2000 microliters had the most effect on fungi growth and sporulation, and mistletoe water extract showed the least effect. Moreover, acetone extract in 2000 microliters, inhibited sporulation by 99 %. It can be concluded that the methanol extract of mistletoe can be a more effective antifungal agent to inhibit the growth and sporulation of Aspergillus flavus than other solvents Manuscript profile