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Open Access Article
1 - The association of dietary acid load with non-alcoholic fatty liver disease among Iranian adults
Pegah Rahbarinejad Maryam Mohamadi Narab -
Open Access Article
2 - Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat
Md Rafiul Haque Md Afroz Ahmad Kamran Ashraf Md Habban Akhter Mohammad Jameel Abuzer Ali Wasim Akhtar Monika Dhaka Kavita Rana -
Open Access Article
3 - The EffectOf an Endurance Training Period on Plasma Alanine Aminotransferase Level in Patients with Nonalcoholic Fatty LiverDisease
Elham Karami Mehdi Reza Gholi Zadeh Hasan Ahanghar Khalil MahmoodiInroduction and Objective: The purpose of current research is to study effect of a selected endurance training period on alanineaminotransferase (ALT) of plasma in patients with nonalcoholic fatty liverdisease (NAFLD).Materials and Methods: So 20 subjects (10 males and MoreInroduction and Objective: The purpose of current research is to study effect of a selected endurance training period on alanineaminotransferase (ALT) of plasma in patients with nonalcoholic fatty liverdisease (NAFLD).Materials and Methods: So 20 subjects (10 males and 10 females) were grouped randomly to 10 people experimental group and 10 people control group. The experimental subjects participated in 12 week endurance training (3 day a week, each session 45 minute and at 60% maximal heart rate) despite of control group. Blood sampling was done before and after 12 week period in order to measure plasma ALT using the colorimetric method. Data were analyzed using dependent and independent paired t-tests at significance level.Results: The results of research demonstrated that endurance training period cause significant reduction on ALT of plasma in experimental group, while that wasn't changed in control group.Conclusion:It was concluded that we can utilize to perform endurance training to reduce ALT of plasma in NAFLD and improve them. Manuscript profile -
Open Access Article
4 - The Effect of Uinoa Extract on Non-Alcoholic Fatty Liver Indices In Hamsters
MOHAMMAD REZA EBAD SICHANI PARNIA POURHADI elham Moghtadaiee khorasganiInroduction & Objective: Non-alcoholic fatty liver disease, which is on the rise worldwide, is one of the chronic liver injuries from steatosis to liver cirrhosis. The aim of this study was to evaluate the effect of quinoa extract on non-alcoholic fatty liver produc MoreInroduction & Objective: Non-alcoholic fatty liver disease, which is on the rise worldwide, is one of the chronic liver injuries from steatosis to liver cirrhosis. The aim of this study was to evaluate the effect of quinoa extract on non-alcoholic fatty liver produced by high fat diet in hamstersMaterial and Method: In this experimental study, 50 hamsters were randomly divided into two groups: high-fat diet (40 heads) and control group (10 heads). After 1 month of high fat diet, hamsters were divided into 4 groups of 10. This group used a high-fat diet, the other 3 groups that received the extract diet were divided into doses of 400, 200, 100 mg / kg and were treated with the extract for 2 months. At the end of liver histology, the activity of liver enzymes and lipid profile in serum were examined.Results: Elevated serum triglycerides and cholesterol were seen in hamsters fed a high-fat diet (p<0.05). Treatment with the extract in different doses did not cause significant biochemical changes except in triglyceride and cholesterol in laboratory results(p<0.05). Histopathological results also confirmed the positive effects of quinoa extract treatment.Conclusion: Eating a high-fat diet led to fatty liver disease, which treatment with quinoa seed extract improved the symptoms of this disease. Manuscript profile -
Open Access Article
5 - The effect of incremental aerobic exercise after injection of bone marrow-derived stem cells on some indicators of oxidative stress and inflammatory of liver tissue in rats model of fatty liver
hamed Namdar Seyed Abdollah Hashemvarzi Abdorreza Jafari ChashmiIntroduction: Non-alcoholic fatty liver disease is one of the most common liver diseases of this century, which is associated with changes in inflammatory cytokines and increased oxidative stress.The purpose of this research was to investigate the effect of an increasin MoreIntroduction: Non-alcoholic fatty liver disease is one of the most common liver diseases of this century, which is associated with changes in inflammatory cytokines and increased oxidative stress.The purpose of this research was to investigate the effect of an increasing aerobic exercise period after bone marrow stem cell injection on some indicators of oxidative and inflammatory stress of liver tissue in rats model of fatty liver. Methods: 60 adult male Wistar rats were divided into two main groups: control (6 rats) and patients with fatty liver (54 rats). The control group used standard rodent food for 6 weeks, while the animals in the diseased groups used high-fat food to induce fatty liver disease. At the end of the sixth week, to confirm the development of fatty liver disease, blood was randomly drawn from the tails of 3 mice and ALT and AST enzymes were measured. Then the animals of the patient group were randomly divided into 5 groups: Saline, Fatty liver, Exercise, Cell, Exercise + Cell. About 105 cells in 2 microliters of medium were injected into the cell receiving groups for each rat through the tail vein. The training program consisted of 8 weeks of incremental treadmill running.Results: The levels of CAT and SOD increased in the treated groups, but the level of the inflammatory index TNF-α decreased, but these changes were significant only in the groups of exercise and exercise + cells compared to the fatty liver group.Conclusion: Incremental aerobic training after the injection of bone marrow-derived stem cells increased the antioxidant levels of CAT and SOD and decreased the inflammatory index of TNF-α in mice with fatty liver. Therefore, it seems that this method can improve liver condition and be considered as a therapeutic solution. Manuscript profile -
Open Access Article
6 - Association between biochemical parameters and pathological findings in the diagnosis of fatty liver in dairy cows
Mehran Shojaei shahin Nejat maryam karimi dehkordi Abdolrasool NamjooThe purpose of this study is to investigate the role of some serum parameters in the diagnosis of fatty liver in cattle with special attention to its degree and to determine the best cut point of these parameters in order to predict the occurrence of fatty liver. Blood MoreThe purpose of this study is to investigate the role of some serum parameters in the diagnosis of fatty liver in cattle with special attention to its degree and to determine the best cut point of these parameters in order to predict the occurrence of fatty liver. Blood and liver samples of 28 cows were taken at the time of slaughter. Serum concentrations of liver enzymes, bilirubin, protein, and lipid profile were determined and the ratio of blood lipids to HDL was calculated. BCS and age of the cows were also recorded. ROC statistical model was used to determine critical thresholds for fatty liver prediction. As the severity of fatty liver increases, AST, GGT, cholesterol and HDL increases, and these can be used as a biomarker to identify severe and mild fatty liver. Also, the severity of the disease increases as the BCS decreases and age increases. ROC analysis showed that AST, GGT, protein, cholesterol to HDL, BCS and age are suitable for predicting the disease. The best cut-off point for predicting fatty liver was suggested as 55.05 IU/L for AST, 14 U/L for GGT, 6.55 mg/dl for total protein and 3.18 for cholesterol to HDL ratio. The best cut point for BCS and age was 4.25 and 6.5 years, respectively. The result showed that measurement of liver enzymes and lipid profile is of acceptable diagnostic importance in determining the degree of fatty liver in cows in field conditions and can be a suitable method to replace liver biopsy. Manuscript profile -
Open Access Article
7 - Evaluation of the correlation between serum levels of non-esterified fatty acids (NEFA), total bilirubin (TB) and glucose (Gluc) and prevalence of fatty liver syndrome based on uterine status in dairy cattle of Tabriz province
A.P Reazei SaberFatty liver is major metabolic disorder that affects approximately half of multiparous dairy cows mildly or severely in early lactation. The purpose of this study was to evaluate the frequency of fatty liver syndrome by measuring the serum levels of NEFA, TB and Gluc in MoreFatty liver is major metabolic disorder that affects approximately half of multiparous dairy cows mildly or severely in early lactation. The purpose of this study was to evaluate the frequency of fatty liver syndrome by measuring the serum levels of NEFA, TB and Gluc in dairy cattle of Tabriz province. For this propose, 400 blood samples were collected from cattle. The sampled cows were divided into four groups according to their pregnancy status: 1-8 months pregnant, 8-9 months pregnant, less than a month after parturition and more than a month after parturition. Serum levels of NEFA, TB and Gluc were measured spectrophotometrically. In this survey, serum NEFA levels were significantly different between the four treatment groups (p<0.001). Also it was noticed that serum NEFA concentration was significantly higher (p<0.001) during the first month of parturition (1125.58±123.60 mEq/L). Also, serum TB and Gluc levels were significantly different between the four treatment groups (p<0.001) during the first month of parturition. The results also showed that with increase in levels of serum NEFA in four treatments groups, serum levels of TB was increased and serum levels of Gluc was decreased (p<0.001). The results also indicated that among the cows studied, fatty liver syndrome is prevalent especially in the first month after parturition. There was no significant correlation between serum NEFA levels and age of the cows (p>0.05). Manuscript profile -
Open Access Article
8 - The Effect of Two Types of Continuous and Interval Training on Fatty Liver Markers in Women with Type 2 Diabetes
Nafiseh Ghannadzadeh Bahram AbediIntroduction: Fatty liver is recognized as a pathophysiological condition in people with type 2 diabetes. The aim of the present study was to investigate the effect of exercise (intermittent and periodic) training on new markers of fatty liver in women with type 2 diabe MoreIntroduction: Fatty liver is recognized as a pathophysiological condition in people with type 2 diabetes. The aim of the present study was to investigate the effect of exercise (intermittent and periodic) training on new markers of fatty liver in women with type 2 diabetes in Kashan.Materials and methods: Thirty women with type 2 diabetes were randomly divided into three groups: periodic exercise (n= 10), continuous exercise (n= 10) and control group (n= 10). Experimental groups performed pre-specified exercises for 8 weeks. Blood samples were taken from three groups before and after 8 weeks of exercise protocol. Covariance analysis was used to test the research hypotheses. SPSS software was used for statistical analysis.Findings: The results of the present study showed that LAP and FLI decreased significantly after continuous and intermittent training compared to the control group, although no significant change was observed in the HSI and FSI variables.Conclusion: The results showed that 8 weeks of continuous and intermittent exercise significantly decreased LAP and FLI in women with type 2 diabetes. Therefore, it is recommended to include a weekly exercise program in these patients. Manuscript profile -
Open Access Article
9 - The effect of resistance training with different intensities on liver enzymes levels in patients with fatty liver: The case for Ahvaz disciplinary force staff
Abbas Khalili Masoud Nikbakht Mohsen Ghanbarzadeh Sedigheh KarampourIntroduction: Fatty liver disease is the most common cause of liver enzyme disorders. The aim of this study was to evaluate the effect of resistance training with different intensities on liver enzymes levels in patients with fatty liver who were working as disciplinary MoreIntroduction: Fatty liver disease is the most common cause of liver enzyme disorders. The aim of this study was to evaluate the effect of resistance training with different intensities on liver enzymes levels in patients with fatty liver who were working as disciplinary force staff in Ahvaz, Iran.Materials and methods: Participants in this study were patients with fatty liver in age range of 30-50 years who were working as disciplinary force staff in Ahvaz, Iran. Out of 200 patients diagnosed with fatty liver, 30 volunteers were selected and studied in this study. The participants were randomly divided into 3 groups of 10 subjects, including: 1. High-intensity resistance training 2. Moderate-intensity resistance training, and 3. Control group. Using blood sampling, the levels of AST, ALT and ALKp enzymes were measured in the laboratory at the beginning and end of 8 weeks of resistance training. Data normalization was performed using the Kolmogorov-Smirnov and Shapiro-Wilk tests. Also, analysis of variance (ANOVA) and LSD post hoc test were used to examine the differences between the three groups. All statistical analyses were performed using SPSS software version 18 at a significance level of 0.05 (α = 0.05).Findings: The results showed that high intensity resistance training had a significant effect on AST, ALT and ALKp enzymes (P ≤ 0.001). On the other hand, moderate intensity training had a significant effect on AST and ALT enzymes (P ≤ 0.001), while this type of training had no significant effect on ALKp levels (P ≤ 0.099). Conclusion: Both moderate and high intensity resistance training can improve AST, ALT and ALKp enzyme levels; however, high-intensity resistance training seems to play a more prominent part. Manuscript profile -
Open Access Article
10 - The effect of eight weeks of resistance training after transplantation of stem cells derived from adipose tissue on some apoptotic and anti-apoptotic factors of heart tissue in non-alcoholic fatty liver model rats
Erfan Gholami Seyed Abdollah Hashemvarzi Seyedeh Yasaman AsadiIntroduction: Nonalcoholic fatty liver disease is one of the most common chronic hepatic diseases which may be associated with cardiovascular disease. The study was conducted with the aim of investigating the effect of eight weeks of resistance training after stem cell MoreIntroduction: Nonalcoholic fatty liver disease is one of the most common chronic hepatic diseases which may be associated with cardiovascular disease. The study was conducted with the aim of investigating the effect of eight weeks of resistance training after stem cell transplantation in fatty liver model rats. Methods: 36 rats were divided into two groups: control (6 rats) and patients with fatty liver (30 rats). The control group used standard food for 6 weeks, while the animals in the diseased groups used high-fat food to induce fatty liver disease. At the end of the sixth week, to confirm the development of fatty liver disease, blood was randomly drawn from the tails of 3 rats. Then the animals of the patient group were randomly divided into 5 groups Saline, Fatty liver, Exercise, Cell, Exercise + Cell. About 1.5 x 106 stem cells for each mouse were injected into the cell receiving groups through the tail vein. The training program consisted of 8 weeks of climbing the ladder. Results: The amounts of Bax and Bcl-2 of the heart tissue decreased and increased respectively in the treated groups compared to the patient group, but these changes were significant only in the exercise group and exercise + cells compared to the patient group. Conclusion: Non-alcoholic fatty liver disease is significantly associated with cardiac cell apoptosis. Resistance training after stem cell transplantation decreased the Bax and increased the Bcl-2 in heart tissue. Therefore, it seems that this method can be considered as a therapeutic solution. Manuscript profile -
Open Access Article
11 - Role of Oxidized Low-density Lipoprotein in Human Diseases: A Review
Israa Qusay Falih Mohammed A.H. Alobeady Shaima Rabeea Banoon Mohanad Yakdhan Saleh -
Open Access Article
12 - Comparing the Effects of Long-term Continuous and Interval Training on the Serum Levels of Non-alcoholic Fatty Liver Risk Factors in Elite Runners
Ardeshir Zafari Zahra Malekian Broomi Fatemeh Haji Ghorbanizadeh Tahereh Bagherpour Nematollah Nemati -
Open Access Article
13 - Comparison of the Effects of Flaxseed and Nigella Sativa Oils on Liver Enzymes and Some of the Inflammatory Factors in Male Rats with non-Alcoholic Fatty Liver
Mozhgan Rahimi Seyed Ebrahim Hosseini Mohammad Amin edalatmaneshFatty liver is a common metabolic disorder affecting millions of people all over the world. Due to the side effects of most of the chemical drugs used to treat this disease, this study has been performed aiming to investigate the effect of flaxseed and N. sativa oils on MoreFatty liver is a common metabolic disorder affecting millions of people all over the world. Due to the side effects of most of the chemical drugs used to treat this disease, this study has been performed aiming to investigate the effect of flaxseed and N. sativa oils on serum levels of liver enzymes and some of the inflammatory factors in in male rats affected by non-alcoholic fatty liver disease (NAFLD). In this experimental study, 40 mature male rats were randomly assigned to 5 groups (8 rats in each group) include the control group (receiving no treatment), fatty liver (treated by fat emulsion), and the experimenta groups under 6-weeks by fat emulsion, and 28-day treatments by 0.75 ml/kg of flaxseed oil, 5 ml/kg of N. sativa oil, and the combined treatmnet of 0.75+ 5 ml/kg of flaxseed and N. sativa oils, respectively. At the end, after blood sampling and separation of the surface serum of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), BUN (blood urea nitrogen), creatinine, total protein, and interleukin 6 were measured. Data analysis was done by ANOVA and Tukey tests. The results showed that iduction of fatty liver caused significant increase of interleukin-6, total protein, blood urea nitrogen, ALP, ALT, AST enzymes, and creatinine compared to the control group (P˂0.01); while the use of flaxseed and N. Sativa oils alone and their combination caused a significant decrease in the level of the above mentioend (P˂0.01). factors The results showed that N. sativa and flaxseed oils and their combination can decrease the inflammatory serum factors and liver damage caused by fatty liver disorder. Manuscript profile -
Open Access Article
14 - Evaluation of the Effect of Harmaline on the Serum Level of Liver Index Enzymes in a Model of Non-alcoholic Fatty Liver of Male NMRI Mice
Tannaz Kowsari Moghadam Hanieh Jafary Parichehreh YaghmaeiRight now, one of the most common liver disorders is fatty liver, on the rise in the world today due to the poor lifestyle of those suffering from it. The aim of this study was to investigate the effect of the active ingredient of Peganum harmala, harmaline, on serum le MoreRight now, one of the most common liver disorders is fatty liver, on the rise in the world today due to the poor lifestyle of those suffering from it. The aim of this study was to investigate the effect of the active ingredient of Peganum harmala, harmaline, on serum levels of liver index enzymes in mice with non-alcoholic fatty liver. In this study, 40 adult male NMRI mice were divided into five groups of 8, including control, HFD, sham (HFD received distilled water, a harmaline solvent.), harmaline receiving 50 mg/kg and 100 mg/kg. Harmaline was injected intraperitoneally for four weeks. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lipid profile (cholesterol, LDL, and HDL) were measured to assess liver function. The activity of antioxidant enzymes such as catalase, glutathione peroxidase, and superoxide dismutase (SOD) in liver tissue were evaluated. Histological studies were performed using Hematoxylin-Eosin staining in liver tissue. Serum levels of ALT, AST, ALP, cholesterol, LDL were significantly decreased in the groups treated with harmaline and the levels of antioxidant enzymes catalase, glutathione peroxidase, and SOD were significantly increased in the treated groups. HDL levels increased significantly in harmaline-treated groups. The results indicated the antioxidant properties of harmaline, one of the most important alkaloids of Peganum harmala.. Manuscript profile -
Open Access Article
15 - The Effect of a Period of High-intensity Interval Training on the Expression of Plasma Levels of AST and ALT Enzymes in the Cardiac Tissue of Wistar Rats with Fatty Liver
Elham Mirzaeyan Mania Roozbayani Hossein ShirvaniHigh-intensity interval training (HIIT) is a kind of exercise training that is suggested for individuals with sufficient time for regular training. This study aimed to evaluate the effect of a period of intense intermittent training on the expression of plasma lev MoreHigh-intensity interval training (HIIT) is a kind of exercise training that is suggested for individuals with sufficient time for regular training. This study aimed to evaluate the effect of a period of intense intermittent training on the expression of plasma levels of AST, and ALT enzyme in the cardiac tissue of male rats with fatty liver (steatosis model). The statistical sample consisted of 48 male Wistar rats (in2 healthy models with fatty liver) aged 5 weeks and weighing 200-250 and in the same conditions (12:12 darkness and light, temperature 22 ± 2 degrees Celsius (50-60%) humidity (51% humidity) were kept in cages. Gene expression was assessed using Real-timePCR and AST, and ALT enzyme was assessed using ZiestChem diagnostic kits. Data were analyzed by independent t-test, one-way analysis of variance, and Tukey's post hoc test, and the data were analyzed by SPSS software version 22. According to the results, the expression of ASTandALT enzymes in the rats of the patient group increased compared to the rats of the healthy group (p < 0.05), which according to the level of significance It was significant. It seems that a period of intense intermittent training affects the expression of plasma levels of ASTand ALT enzymes in the cardiac tissue of male rats with fatty liver (steatosis model) and can serve as a marker for the prevention and treatment of diseases. Use cardiovascular, fatty liver, obesity as well as diabetes. Keywords:, AST, ALT anzem, HIIT exercise Manuscript profile -
Open Access Article
16 - Comparison the Effects of Vitamin E and Propolis on Interleukin-5 and STAT1 Gene Expression in Wistar Rats with Non-alcoholic Fatty Liver Disease
Saeede Baarforoush Maryam Bananaj Ramin Hajikhani Hengameh AlibeikNonalcoholic fatty liver disease (NAFLD) is a growing health concern worldwide. Unfortunately, scientists have not succeeded in finding a suitable treatment method for this disease, and more research is needed. Studies have shown that treatment with antioxidants is effe MoreNonalcoholic fatty liver disease (NAFLD) is a growing health concern worldwide. Unfortunately, scientists have not succeeded in finding a suitable treatment method for this disease, and more research is needed. Studies have shown that treatment with antioxidants is effective in this disease. In this study, the effect of two different antioxidants on NAFLD induced in male Wistar rats was evaluated. This study was conducted on 32 male Wistar rats weighing 200 grams, which were randomly divided into four groups of eight. Mice were fed by gavage with high-fat emulsion at the rate of 2 mg/kg for 40 days. After suffering from fatty liver, the level of interleukin-5 (IL-5) in the serum was measured and also the expression level of STAT1 gene was determined using real-time PCR. The results showed that the level of serum IL-5 in the patient group significantly increased compared to the control group, and the treatment groups with vitamin E and propolis, significantly decreased the level of interleukin-5 compared to the patient group (p < 0.05). In addition, the greatest decrease was related to the propolis group (p < 0.05). On the other hand, the level of STAT1 gene expression in the fatty liver group is significantly increased compared to the control group (p < 0.05); Whereas, after treatment with antioxidants, the expression of this gene decreased (p < 0.05). Based on the obtained results, the use of propolis and also vitamin E as natural antioxidants by reducing the inflammatory interleukin and also reducing the expression of genes effective in the formation of NAFLD, have a promising therapeutic role in non-alcoholic fatty liver disease. Manuscript profile -
Open Access Article
17 - Effect of endurance training on bile acid synthesis signaling pathway in rats with non-alcoholic fatty liver disease
Mehri Gholipour Najmeh Rezaeian Mohammad Karimi Sadegh Cheragh BirjandiNon-alcoholic fatty liver disease (NAFLD) is the most common liver dysfunction and one of the most important causes of death from chronic liver diseases. The purpose of this study is to investigate the effect of eight weeks of endurance training compared to resistance t MoreNon-alcoholic fatty liver disease (NAFLD) is the most common liver dysfunction and one of the most important causes of death from chronic liver diseases. The purpose of this study is to investigate the effect of eight weeks of endurance training compared to resistance training on liver bile acids (BA), relative expression of farnesoid X receptor (FXR), fibroblast growth factor 15 (FGF15), fibroblast growth factor receptor 4 (FGFR4) and beta protein Klotho (KLB) in rats with non-alcoholic fatty liver disease. In this experimental study, 16 Wistar rats with an approximate weight of 120-160 grams, after induction of NAFLD conditions, with six weeks of high-fat diet were randomly divided into two equal groups (8 rats in each group), including; Control (C), endurance training (E). group E participated in an incremental treadmill exercise protocol with an intensity of 65% of maximal oxygen consumption and a frequency of 5 sessions per week. 48 hours after the last training session, the subjects were sacrificed and liver tissue and blood samples were taken to evaluate the research variables. Data were analyzed by using independent t-test. The findings showed that E training protocols led to a significant decrease in liver BA values (p = 0.0001). Also, in the E training group, a significant increase in the relative expression of FXR, FGF15, FGFR4 and KLB protein levels was observed (p = 0.0001). In conclusion, it seems that endurance exercise can have positive effects on the variables involved in the signaling of bile acid synthesis. . Manuscript profile -
Open Access Article
18 - Therapeutic Effect of Sitagliptin and Berberine Interaction on Fatty Liver and Hepatic GLUT4 Gene Expression in Diabetic Male Rats
Soraya Mehrdoost Parichehreh Yaghmaei Hanieh Jafari Azadeh Ebrahim-HabibiFatty liver disease causes accumulation of excess fat in liver cells. Berberine has antioxidant and anti-inflammatory activities, and Sitagliptin is a DPP-4 inhibitor that increases the function of incretin hormones. In this study biological activities of Berberine and MoreFatty liver disease causes accumulation of excess fat in liver cells. Berberine has antioxidant and anti-inflammatory activities, and Sitagliptin is a DPP-4 inhibitor that increases the function of incretin hormones. In this study biological activities of Berberine and Sitagliptin for the treatment of fatty liver in diabetic Sprague-Dawley rats were investigated. The therapeutic effects of Sitagliptin and Berberine on fatty liver in diabetic rats by Alloxan injection with a single dose of 100 mg/kg were done with the following groups. Groups include 1: control (physiology serum as Alloxan solvent); 2: model (fatty liver + Alloxan); 3: Sitagliptin (fatty liver + Alloxan and Sitagliptin 10 mg/kg); 4: Berberine (fatty liver + Alloxan and Berberine 150mg/kg); 5: Berberine/Sitagliptin (fatty liver + Alloxan and Sitagliptin 5 mg/kg and Berberine 75 mg/kg). After the treatment, the liver tissue separated and weighed. Levels of Liver triglyceride, cholesterol and GLUT4 gene expression in liver tissue measured by real-time PCR method. The level of GLUT4 gene expression levels increased in the treatment groups compared to the model group, but a significant difference was seen only in the co-administration group with the model group (p < 0.05). There was a significant decrease in the amount of liver cholesterol in the treatment groups compared to the model group (p < 0.01). Hepatic triglyceride decreased in the treatment groups, but only in the co-administration group, a significant difference was seen with the model group (p < 0.05). Berberine and Sitagliptin, especially when prescribed together with the increased expression of GLUT4 and the reduction of liver cholesterol and triglycerides, have a favorable effect on lipid metabolism and can be considered as an effective treatment for hyperlipidemia and fatty liver. Manuscript profile -
Open Access Article
19 - Investigating the Interactive Effects of Berberine and Sitagliptin on Lipid Profile, Glucose and Insulin Levels in Diabetic Male Rats with Fatty Liver
Soraya Mehrdoost Parichehreh Yaghmaei Hanieh Jafary Azadeh Ebrahim-HabibiHepatic insulin resistance is associated with NAFLD and it is a major factor in the pathogenesis of type 2 diabetes and metabolic syndrome. Insulin resistance causes lipolysis in adipose tissue and disturbance in the regulation of lipid metabolism causes fat accumulatio MoreHepatic insulin resistance is associated with NAFLD and it is a major factor in the pathogenesis of type 2 diabetes and metabolic syndrome. Insulin resistance causes lipolysis in adipose tissue and disturbance in the regulation of lipid metabolism causes fat accumulation in the liver. In this study, the biological activities of Berberine and Sitagliptin to improve insulin resistance and lipid profile in Sprague-Dawley rats with type 2 diabetes was investigated. groups include 1: control (physiological serum as an alloxan solvent); 2: model (fatty liver + Alloxan); 3: Sitagliptin (fatty liver + Alloxan and Sitagliptin 10 mg/kg); 4: Berberine (fatty liver + Alloxan and Berberine 150mg/kg); 5: Berberine/Sitagliptin (fatty liver + Alloxan and Sitagliptin 5 mg/kg and Berberine 75 mg/kg). At the end of the treatment period, under anesthesia, Blood sampling done from the heart and lipid profile, glucose and insulin measured. The amount of triglyceride (p < 0.01), cholesterol (p < 0.05), LDL (p < 0.01), FFA (p < 0.05), fasting glucose (p < 0.05) and insulin (p < 0.01) in the coadministration group decreased compared to the model group and HDL increased, which was not significant. Berberine and Sitagliptin, especially when administered together, have a favorable effect on lipid metabolism and insulin resistance and can be considered as an effective treatment regimen for hyperlipidemia and fatty liver. Manuscript profile -
Open Access Article
20 - Effect of Eight Weeks Resistance Training on Serum Levels of Hepatic Enzymes Including AST, ALT and ALP in Overweight Mens with Nonalcoholic Fatty Liver Disease
S. Nejadsalim M. GholamiThe effect of different types of exercise training in patients with nonalcoholic fatty liver disease (NAFLD) is unclear. Therefore, the aim of present study was to investigate the effect of eight weeks’ resistance training on serum levels of hepatic enzymes' inclu MoreThe effect of different types of exercise training in patients with nonalcoholic fatty liver disease (NAFLD) is unclear. Therefore, the aim of present study was to investigate the effect of eight weeks’ resistance training on serum levels of hepatic enzymes' including AST, ALT and ALP in overweight men’s afflicted by NAFLD. For this purpose, 30 overweight men’s afflicted by NAFLD with average age 40.2 ± 2.5 and weight 75.5 ± 3.19 randomly divided in control (n=15) and resistance training (n=15) groups. Subjects in training group take part in resistance training program for eight weeks and three sessions per week. Training intensity increased from 40 percent of 1RM in first week to 70 percent of 1RM in last week. Blood samples collected in the end of research protocol and given variables measured in serum. Present study result analyzed by SPSS-24 software and using analyze covariance (ANCOVA) test. Results indicated that serum levels of AST (p= 0.024) and ALT (p= 0.006) significantly decreased in resistance training group, but changes in serum levels of ALP wasn’t significant (p= 0.096). Moreover, result indicated significant improvement of lipid profile in trained group (p= 0.001). According to present study result, positive effect of resistance training in patient with NAFLD may be exert by decreasing levels of hepatic enzyme and this training program can play effective role in modulating lipid profile in patient with NAFL. Manuscript profile
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