The Effect of a Period of High-intensity Interval Training on the Expression of Plasma Levels of AST and ALT Enzymes in the Cardiac Tissue of Wistar Rats with Fatty Liver

Subject Areas : Journal of Animal Biology

Elham  Mirzaeyan ¹ (Department of ExercisePhysiology, Boroujerd, Branch, Islamic Azad University, Boroujerd, Iran)
Mania  Roozbayani ² (Department of ExercisePhysiology, Boroujerd, Branch, Islamic Azad University, Boroujerd, Iran)
Hossein  Shirvani ³ (Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran)

Received: 2022-08-25 Accepted : 2022-10-23 Published : 2023-05-22

Keywords: Fatty liver, AST, ALT Enzyme, HIIT Exercise,

Abstract :

High-intensity interval training (HIIT) is a kind of exercise training that is suggested for individuals with sufficient time for regular training.  This study aimed to evaluate the effect of a period of intense intermittent training on the expression of plasma levels of AST, and ALT enzyme in the cardiac tissue of male rats with fatty liver (steatosis model). The statistical sample consisted of 48 male Wistar rats (in2 healthy models with fatty liver) aged 5 weeks and weighing 200-250 and in the same conditions (12:12 darkness and light, temperature 22 ± 2 degrees Celsius (50-60%) humidity (51% humidity) were kept in cages. Gene expression was assessed using Real-timePCR and AST, and ALT enzyme was assessed using ZiestChem diagnostic kits. Data were analyzed by independent t-test, one-way analysis of variance, and Tukey's post hoc test, and the data were analyzed by SPSS software version 22. According to the results, the expression of ASTandALT enzymes in the rats of the patient group increased compared to the rats of the healthy group (p < 0.05), which according to the level of significance It was significant. It seems that a period of intense intermittent training affects the expression of plasma levels of ASTand ALT enzymes in the cardiac tissue of male rats with fatty liver (steatosis model) and can serve as a marker for the prevention and treatment of diseases. Use cardiovascular, fatty liver, obesity as well as diabetes. Keywords:, AST, ALT anzem, HIIT exercise

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