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Open Access Article
1 - In vivo anti-inflammatory and anti-nociceptive activities, and chemical constituents of essential oil from the leaf of Gardenia jasminoides J. Ellis (Rubiaceae)
Nudewhenu Opeyemi Avoseh Oladipupo Adejumobi Lawal Isiaka Ajani Ogunwande Roberta Ascrizzi Guido Flamini Elizabeth AmooThe chemical constituents, anti-inflammatory and anti-nociceptive activities of the leaf essential oil hydrodisitlled from the Gardenia jasminoides J. Ellis (Rubiaceae) were reported. The chemical constituents of the essential were analyzed using gas chromatography-flam MoreThe chemical constituents, anti-inflammatory and anti-nociceptive activities of the leaf essential oil hydrodisitlled from the Gardenia jasminoides J. Ellis (Rubiaceae) were reported. The chemical constituents of the essential were analyzed using gas chromatography-flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). The hot plate and carrageenan-induced models were used to determine the anti-nociceptive and anti-inflammatory activities. The main compounds of the oil were pentadecanal 17 (49.2%), geranial 4 (12.3%), ar-turmerone 14 (8.2%) and 10-epi-γ-eudesmol 10 (6.2%). The essential oil of G. jasminoides at 100 and 400 mg.kg-1 doses significantly (p < 0.001) increased the latency period for the reaction duration in the anti-nociceptive study. The carrageenan-induced edema model reveals the suppression of inflammatory mediators (p < 0.001) within 1st, 2nd and 4th h for 100 mg.kg-1 dose, 1st and 4th h (200 mg.kg-1) and 1st-3rd h (400 mg.kg-1). The results indicate the potential of G. jasminoides essential oil as a source of pain relieving agent. Manuscript profile
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