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    • List of Articles ناصر کلهر

      • Open Access Article

        1 - The study of the effects and side effects of methyldopa drug on changes in male rat kidney tissue
        Mehdi Ahmadifar سید مهدی کلانتر ناصر کلهر سپیده جعفرزاده راستین فاطمه تقوایی مهدی لطفی پناه
        Introduction: Increased kidney disease in human societies is now one of the urologists concerns. Many of these kidney disorders can be caused by various drugs including blood pressure lowering drugs.Methods: In this experimental study, 40 male wistar rats were used. The More
        Introduction: Increased kidney disease in human societies is now one of the urologists concerns. Many of these kidney disorders can be caused by various drugs including blood pressure lowering drugs.Methods: In this experimental study, 40 male wistar rats were used. The rats were divided into 4 groups of 10 including control, first, second and third experimental groups which received respectively water, 0.03, 0.06 and 0.08 mg/ kg methyldopa drug via gavage. After 1 month, these40 mice were anesthetized and their kidneys were removed.After preparing microscopic sections, they were stained using H & E staining and stained samples were observed with a light microscope. Then images of desired samples were prepared using a light microscope equipped with camera.Results: the obtained results shows that the consumption of high doses methyldopa drugs lead to disturbance in kidney function and related enzymatic processes. Moreover it can cause remarkable changes in different kidney layers.Conclusion:regarding obtained results, prescribing methyldopa drug should be done more carefully. Manuscript profile
      • Open Access Article

        2 - The effect of caffeine intake on the risk of cardiovascular disease
        Mehdi Ahmadifar نازیلا وحیدی ایریسفلی1 غلامحسین واعظی حسن باقری یزدی ناصر کلهر Reihane Nateghi
        Introduction:Caffeine is a chemical and edible substance, which is found in some foods, such as coffee, cocoa, cola, tea, chocolate and some drinks. Caffeine is the most widely used drug among people and almost 90 percent of people are using it on a daily basis. Given t More
        Introduction:Caffeine is a chemical and edible substance, which is found in some foods, such as coffee, cocoa, cola, tea, chocolate and some drinks. Caffeine is the most widely used drug among people and almost 90 percent of people are using it on a daily basis. Given that taking food and drinks containing caffeine including chocolate, tea and coffee is very high in Iran as well as its effects on cardiovascular disease is still not fully understood; hence, the purpose of this research was to study the effects of caffeine on cardiovascular diseases and to report the results of research conducted in this regard.Research Methodology: In this study, library collection, searching the scientific literature and papers were used. The views of relevant experts were also examined.Results:The results showed that using tea has no harmful effects on the cardiovascular system. According to obtained results chocolate consumption will reduce both systolic and diastolic blood pressure. In general, drinking coffee causes increased blood pressure, irregular heartbeat, increased blood cholesterol, increased levels of homocysteine and increased risk of heart attacks. Several studies indicated fetal cardiac arrhythmias caused by excessive consumption of caffeine in pregnant women.Conclusions: According to the results, green and black tea has no harmful effects on cardiovascular diseases, but in some cases positive effects have also been reported. Consumption of chocolate, cocoa and coffee have harmful effects on the cardiovascular system. Due to the effects of caffeine on pregnant women, consumption of coffee and caffeine should be reduced during pregnancy. Manuscript profile
      • Open Access Article

        3 - Survey relationship between rs2303169 polymorphism in FBN3 gene in patients with polycystic ovary syndrome
        Reyhaneh Kalhor naser kalhor Hourieh Kalhor Mojtaba Sohrabi
        Abstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertil More
        Abstract Introduction: Polycystic ovary syndrome (PCOS) is a very complex and heterogeneous disorder that genetic and environmental factors have a significant contribution to its creation. PCOS is the commonest endocrine abnormality in 6 to 10 percent of women in fertility age that FBN3 gene is one of the most important candidate genes, for PCOS. This gene has 20 polymorphisms. This study examines the relationship between rs2303169 polymorphism in FBN3 gene in women with PCOS. Method: This study is a case-control study which is done on 100 women with PCOS and 100 healthy women. In this research, Tetra-ARMS PCR method was used to study the relationship between rs2390169 genotypes in FBN3 gene and the probability of getting PCOS in both patient and control groups. Connecting data from this study are analyzed statistically using SPSS software, chi-squared tests and Independent student t-test. Results: The results of the research showed no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS (P = 0.152). Also, CT and TT genotypes increased the probability of getting PCOS to 1,995 and 1,621 times towards CC genotype respectively. Conclusion: For the first time, this study showed that there is no significant relationship between rs2303169 polymorphism in FBN3 gene and PCOS. However, relationship between polymorphisms of other genotypes in FBN3 gene and PCOS needs a wider research in greater populations and different ethnicities in the country. Key words: Polycystic ovary syndrome; Polymorphism; FBN3 gene. Manuscript profile
      • Open Access Article

        4 - A review of platelet-rich fibrin and its application in the treatment of diseases
        Naser Kalhorqom Mohsen Sheykhhasan Fatemeh Nasiri Azar Sheikholeslami
        Two decades have passed since platelet rich fibrin (PRF) was first introduced. The primary objective was to develop a therapy where platelet concentrates could be introduced into wounds by effectively utilizing the body’s natural healing capacity. This was achieve More
        Two decades have passed since platelet rich fibrin (PRF) was first introduced. The primary objective was to develop a therapy where platelet concentrates could be introduced into wounds by effectively utilizing the body’s natural healing capacity. This was achieved by collecting growth factors derived from blood in a natural way. Platelet rich plasma (PRP) and platelet rich growth factor (PRGF) had been commercialized, yet both contained secondary byproducts that were both unnatural and known inhibitors of wound healing. By removing these anti-coagulants and modifying centrifugation protocols, PRF was introduced some years later with the potential to markedly impact many fields of medicine including dentistry. Many aspects important for tissue regeneration have since been revealed including the important role of fibrin as well as the preferential release of growth factors over longer periods of time from PRF. Furthermore, by introducing a new set of cells into platelet concentrates, a marked impact on tissue regeneration and wound healing was observed. Further modifications to centrifugation speed and time have additionally improved PRF into a concept. Investigators began to modify surgical techniques to favorably treat patients with PRF with improved clinical outcomes. In this first chapter, we highlight the discovery of PRF and the studies leading to its first use in regenerative medicine. We focus specifically on its properties for wound healing and how its presented advantages over previous versions of platelet concentrates have favorably enhanced the regenerative potential of platelet concentrates in dentistry. Manuscript profile