Mohammad Reza Mokhber Dezfouli Articles List

List of Articles Mohammad Reza Mokhber Dezfouli

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1 - Evaluation of plasma concentration of atrial natriuretic peptide (ANP) in horses with pulmonic valve regurgitation
Mohamad Hasan Najizadeh Mohammad Reza Mokhber Dezfouli ُSirus Sadeghian Chleshtori Gholamreza Nikhbakht Borujeni Alireza Vajhi Masoumeh Jabbari Fakhr Mohammadreza Mehrara hossein shad
10.30495/jvcp.2020.1908982.1280

Atrial natriuretic peptide (ANP) is secreted by cardiac myocytes and its plasma concentration often increases in patients with cardiovascular disease in response to blood volume expansion and stretching of cardiac chambers. Increase in plasma concentration of ANP (Cp AN More

Atrial natriuretic peptide (ANP) is secreted by cardiac myocytes and its plasma concentration often increases in patients with cardiovascular disease in response to blood volume expansion and stretching of cardiac chambers. Increase in plasma concentration of ANP (Cp ANp ) has been observed in humans with cardiac diseases and horses with left-sided valvular disease. This study aimed to investigate plasma ANP level in horses with pulmonic valve regurgitationand its association with echocardiographic parameters. Clinical and echocardiographic examinations were performed on several jumping horses in the equestrian clubs of Tehran, Iran. Eleven horses with pulmonic valve regurgitation were identified by echocardiographic examination and were included in the case group (Group A), and 14 healthy horses were taken as the control group (Group B). Then, B-Mode, M-Mode and doppler echocardiographic parameters were measured and compared between the two groups. Blood samples from the jugular vein were collected in tubes and were transferred to laboratory. Cp ANp was measured by Sandwich ELISA method using an equine specific kit.MeanCp ANp of horses in group1 and group2 were 6.39±2.87 pg/ml and 4.78±2.45 pg/ml respectively, but no significant differences were observed. Except for right ventricular internal diameter, other echocardiographic parameters were not significantly different between the two groups. Cp ANp was significantly correlated to systolic right ventricle length and left ventricular width. In conclusionno significant differences were observed between Cp ANp of healthy horses and horses with pulmonic regurgitation. Based on the Correlation between CpANP and right ventricle length, an elevation in Cp ANp might be expected in severe pulmonic regurgitation with change in ventricle`s dimensions.    Manuscript profile
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2 - Effect of active vitamin D3 on the expression of antimicrobial peptide genes in experimental calf pneumonia
Parisa asgharpour Zohreh Eftekhari Mohammad Gholi Nadealian Gholamreza Nikhbakht Borujeni Mohammad Reza Mokhber Dezfouli
10.30495/jvcp.2021.1935390.1311

The outbreak of calf pneumonia in herds occurs due to different pathogens. Vitamin D3 displays a regulatory effect on different cells, especially its pro-differential biological function and stimulates antimicrobial peptides. In the present study, the effects of vitamin More

The outbreak of calf pneumonia in herds occurs due to different pathogens. Vitamin D3 displays a regulatory effect on different cells, especially its pro-differential biological function and stimulates antimicrobial peptides. In the present study, the effects of vitamin D3 on the expression of antimicrobial peptides in experimental pasteurellosis in calves were assessed. Ten Holstein calves (2-4 months old) were randomly divided into two groups. Prepared Pasteurella multocida (3×109 CFU/mL) was inoculated in the trachea of all calves and Vitamin D3 was injected only in the treatment group following confirmation of pneumonia. Blood samples and broncho-alveolar lavage fluids were obtained from both groups at different time intervals and the peripheral blood mononuclear cells were isolated to evaluate the antimicrobial peptides gene expression. The expression of CD4, Cathelicidin, and Defensins genes was measured in vitro conditions following the addition of 10-6, 10-7 and 10-8 molar of vitamin D3. Defensins and CD4 gene expressions revealed a significant difference in the two groups, at the 48, 72, 96, and 120 hours after the challenge time, while the Cathelicidin gene was not expressed in both experimental groups. Surprisingly, increased expression of Cathelicidin, Defensins, and CD4 was observed at a concentration of 10-6 M of vitamin D3. According to the results of this study, vitamin D3 had positive effects on the immune system which was observed as significant improvement in the clinical symptoms of treated calves. The expression of lung-related Defensins and CD4 in vivo and in vitro approved the immunomodulatory effects of vitamin D3 but the gene expression of Cathelicidin is probably related to prescribing higher doses of vitamin D3. Manuscript profile

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List of Articles Mohammad Reza Mokhber Dezfouli