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  • List of Articles


      • Open Access Article

        1 - A review on the role of irisin and adipolin in diabetes and obesity conditions with an exercise approach
        Maryam Shojaee Saleh Rahmati
        The interplay between irisin, adipolin, physical activity, diabetes, and obesity is a multifaceted and complex issue with important implications for our understanding of metabolic health. Irisin and adipolin are cytokines that are secreted during physical activity. Thes More
        The interplay between irisin, adipolin, physical activity, diabetes, and obesity is a multifaceted and complex issue with important implications for our understanding of metabolic health. Irisin and adipolin are cytokines that are secreted during physical activity. These cytokines play an important role in regulating metabolic functions in the body. Irisin, in particular, has received attention for its potential to increase thermogenesis and improve glucose homeostasis. It has been shown that physical activity increases the secretion of irisin, which leads to increased fat burning and energy consumption. Irisin turns white fat tissue into brown and helps to lose weight and prevent obesity. In the field of diabetes, irisin is promising as a potential therapeutic target. Studies have shown that irisin can increase insulin sensitivity and glucose uptake in skeletal muscle cells, which may be beneficial for people with type 2 diabetes. Additionally, irisin has anti-inflammatory properties and reduces chronic low-grade inflammation commonly associated with obesity and diabetes. Adipolin is another myokine associated with metabolic health. Similar to the effects of irisin, adipolin has anti-inflammatory properties and helps to regulate the metabolism of adipose tissue. The purpose of this article is to investigate the role of irisin and adipolin in diabetes and obesity with an exercise approach. Manuscript profile
      • Open Access Article

        2 - The effect of 12 weeks of bodyweight training on neurotrophic factors of children with hypotonic cerebral palsy
        leila Akbarifard farzad zehsaz Sajad Anoushirvani Akbar Moein
        The aim of the present study is to determine the effect of 12 weeks of bodyweight training on neurotrophic factors in children with hypotonic cerebral palsy. 20 children with hypotonic cerebral palsy with an average age of 8 to 12 years were selected and placed in two g More
        The aim of the present study is to determine the effect of 12 weeks of bodyweight training on neurotrophic factors in children with hypotonic cerebral palsy. 20 children with hypotonic cerebral palsy with an average age of 8 to 12 years were selected and placed in two groups of body weight training (n=10) and control group (n=10). Subjects of the Bodyweight group performed exercises that included basic strength, maximum strength and high-intensity interval training for 12 weeks and three sessions a week. The training intensity was 25% 1RM in the first to third week, 50% in the fourth to sixth week, 75% in the seventh to ninth week, and 100% in the tenth to twelfth week. Blood samples were taken 24 hours before and 24 hours after the last training session. To analyze the data, independent t-tests were used to survey the inter-group difference and correlated t-test to survey the intra-group difference at a significant level (P<0.05). The results of data analysis showed a significant increase in the levels of neurotrophin factors (BDNF, NGF, IGF-1) in the body weight training group. Due to their structure, Bodyweight exercises can be easily used by children with hypotonic cerebral palsy. It seems that these exercises improve the skeletal muscle tissue in these children by increasing the levels of neurotrophic factors, and by slowing down the atrophy process and reducing the muscle tissue, it improves their movement and posture disorders and balance problems. . Manuscript profile
      • Open Access Article

        3 - The effect of eight weeks of aerobic training on VO2max and BMI of overweight and obese women in different types of NRF1 and NRF2 genotypes
        Maryam Kamari Masoud Rahmati Mehdi Boostani
        Aim: The purpose of this study was to determine the effect of eight weeks of aerobic training on VO2max and BMI of overweight and obese women in different types of NRF1 and NRF2 genotypes.Methods: 23 inactive obese women (30-45 years old, body mass index>30) voluntar More
        Aim: The purpose of this study was to determine the effect of eight weeks of aerobic training on VO2max and BMI of overweight and obese women in different types of NRF1 and NRF2 genotypes.Methods: 23 inactive obese women (30-45 years old, body mass index>30) voluntarily and purposefully participated in the research. At the beginning of the research the subjects participated in an aerobic training program for eight weeks. Measurements related to height, weight, body mass index and VO2max of the subjects were done before and after the training program. 24 hours after completing the training program, in order to extract DNA and observation of genetic profile by RFLP method, saliva samples were collected in special kits. Subjects were placed in three genotypic groups AA, AC and CC for NRF1 and one genotypic group AA for NRF2. To check the frequency of genotypes Chi-square statistical test and one-way ANOVA test and dependent T-test were used to check the difference between variables.Results: The results of analysis related to NRF1 gene showed that there is non-significant difference in VO2max (p=0.854 and F=0.159) and body mass index (p=0.956 and F=0.036) between groups. Also, the results related to the NRF2 gene showed that the subjects' VO2max increased significantly after eight weeks of aerobic training (p=0.001).Conclusion: The present study showed that only in the NRF2 AA genotype, the endurance capacity of subjects increases due to aerobic exercise. Manuscript profile
      • Open Access Article

        4 - The effect of eight weeks of aerobic training on some apoptotic factors of elderly men
        Farzane Tleb Mohammadi bahram abedi Mojtaba Khansooz
        Objective: Impairment in the secretion and function of insulin in different tissues of the body is the main cause of type 2 diabetes. The purpose of this study is to investigate the effect of intense intermittent exercise and thyme honey on GLUT4 gene expression in sole More
        Objective: Impairment in the secretion and function of insulin in different tissues of the body is the main cause of type 2 diabetes. The purpose of this study is to investigate the effect of intense intermittent exercise and thyme honey on GLUT4 gene expression in soleus muscle and insulin resistance index in male obese rats with It is type 2 diabetes.Materials and Methods: In this experimental study, 36 rats (5-8 weeks old, weighing 110±10 g) were randomly divided into 4 groups of diabetes, diabetes-exercise, diabetes-supplement and diabetes-exercise-supplement. To induce type 2 diabetes, STZ was injected intraperitoneally at a dose of 25 mg/kg. Intense interval training was performed for 5 sessions per week for 8 weeks. Thyme honey in the amount of 3 g/kg was gavage in the supplement groups for 5 days a week before training. After blood sampling and tissue sampling, GLUT4 gene expression of soleus muscle and insulin resistance index were measured for data analysis using ANOVA test. Bonferroni's one-sided and post hoc tests were used at a significance level of P<0.05.Findings: Insulin changes in exercise group, supplement and supplement exercise showed a significant increase (P<0.05), insulin resistance values in the supplement group increased significantly compared to the control group (P=0.001). But the changes of this index in the training group showed a significant decrease compared to the control group, supplement and supplement training group. (p≥0.001) The level of GLUT4 has increased significantly in the training group and the training-supplement group. (P<0.05) Glucose changes in the exercise group and the exercise-supplement group were associated with a significant decrease (P<0.05).Conclusion: In addition to the findings of this research, it seems that eight weeks of intermittent exercise alone and together with the consumption of thyme honey improves insulin resistance and increases GLUT4 gene expression in diabetic samples. Manuscript profile
      • Open Access Article

        5 - A review of the effects of resistance training and vitamin D on PI3K/AKT/mTOR signaling pathway
        Parisa Mokhtari Mohammad Ali Azarbayjani Maghsoud Peeri Saleh Rahmati
        Skeletal muscle is a dynamic tissue and undergoes structural and functional changes in response to mechanical load, metabolic stress, drugs and diseases. The most prominent structural change of skeletal muscle is hypertrophy and atrophy. Resistance training is one of th More
        Skeletal muscle is a dynamic tissue and undergoes structural and functional changes in response to mechanical load, metabolic stress, drugs and diseases. The most prominent structural change of skeletal muscle is hypertrophy and atrophy. Resistance training is one of the most important interventions for muscle hypertrophy. By increasing the release of insulin hormones and insulin-like growth factor 1, these exercises activate the AKT/mTOR signaling pathway in skeletal muscle and increase protein synthesis and muscle hypertrophy. Due to the presence of vitamin D receptor in skeletal muscle cells, this vitamin can affect muscle hypertrophy. The review of the studies that were searched from the scientific databases of PubMed, Science Direct, Springer and Google Scholar shows that vitamin D also causes muscle hypertrophy by activating the AKT/mTOR signaling pathway. However, contrary to expectations, the combination of resistance training and vitamin D causes a slight increase in muscle mass and strength. Since the results of studies regarding the effects of the combination of resistance training and vitamin D on muscle hypertrophy are somewhat contradictory, more studies are needed regarding the effects of these two interventions on muscle structure and function. Manuscript profile
      • Open Access Article

        6 - Promoting the health of the elderly: Assessing the quality of life and the cost of treatment based on physical activity
        samira Akbari Hosein AliMohmadi
        The category of quality of life in different strata, especially the elderly who have special mental and psychological conditions is very important, the quality of life taken into account as an important indicator in the study of the health of the elderly. The purpose of More
        The category of quality of life in different strata, especially the elderly who have special mental and psychological conditions is very important, the quality of life taken into account as an important indicator in the study of the health of the elderly. The purpose of this study was to compare the quality of life and treatment costs of the elderly based on the level of sporty participation.The present research is scientific-comparative research in the form of a survey. The statistical sample of this study was 600 elderly people who were selected from the cities of the Khuzestan province, which were selected in the form available. The data collection tool in this present study is a questionnaire and it consisted of three sections: demographic information, treatment costs, and sporty participation and quality of life (whoQo-BREF), which contained 25 questions in six areas. The formal validity and the content of the questionnaire were confirmed by experts. The data analysis in the descriptive statistics section has used the indicators of central tendency and dispersion; in the inferential statistics section, the normal tests of data distribution were used One-way analysis of variance and Schaffer post hoc test. All statistical operations were performed through SPSS software version 20.The results showed that there is a significant difference between the treatment costs and quality of life of the elderly based on the level of sporty participation.It seems that due to the importance of quality of life in the elderly, regular physical activity can be considered as one of the ways to improve the quality of life of the elderly as well as reduce the treatment costs Manuscript profile