A review on the role of irisin and adipolin in diabetes and obesity conditions with an exercise approach
Subject Areas : Physical Activity and Health
Maryam Shojaee
1
,
Saleh Rahmati
2
1 - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
Keywords: exercise training, Fat oxidation, Obesity, Myokine, Cytokine, Diabetes,
Abstract :
The interplay between irisin, adipolin, physical activity, diabetes, and obesity is a multifaceted and complex issue with important implications for our understanding of metabolic health. Irisin and adipolin are cytokines that are secreted during physical activity. These cytokines play an important role in regulating metabolic functions in the body. Irisin, in particular, has received attention for its potential to increase thermogenesis and improve glucose homeostasis. It has been shown that physical activity increases the secretion of irisin, which leads to increased fat burning and energy consumption. Irisin turns white fat tissue into brown and helps to lose weight and prevent obesity. In the field of diabetes, irisin is promising as a potential therapeutic target. Studies have shown that irisin can increase insulin sensitivity and glucose uptake in skeletal muscle cells, which may be beneficial for people with type 2 diabetes. Additionally, irisin has anti-inflammatory properties and reduces chronic low-grade inflammation commonly associated with obesity and diabetes. Adipolin is another myokine associated with metabolic health. Similar to the effects of irisin, adipolin has anti-inflammatory properties and helps to regulate the metabolism of adipose tissue. The purpose of this article is to investigate the role of irisin and adipolin in diabetes and obesity with an exercise approach.
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