List of Articles Myocardial infarction

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  1 - The effect of intra-myocardial injection of secretion of bone marrow-derived mesenchymal stem cell on Myocardial infarction in male rabbits
  narges kakadezfuly maryam naseroleslami nahid aboutaleb
  Background and Aim: Despite the use of stem cells in the treatment of diseases, especially heart disease, there is a lot of ambiguity about the act of cells and their secretions. Therefore, the purpose of this study was to evaluate the effect of secretion of bone marrow More

  Background and Aim: Despite the use of stem cells in the treatment of diseases, especially heart disease, there is a lot of ambiguity about the act of cells and their secretions. Therefore, the purpose of this study was to evaluate the effect of secretion of bone marrow-derived mesenchymal stem cells on myocardial infarction in male rabbits. Materials and Methods: After isolating the stem cells from the bone marrow and preparing the conditioned medium, 30 Male rabbits were randomly divided into three groups(n=10). Myocardial Infarction was induction in two groups and in a group conditioned medium was injected into the hearts of rabbits. Then in the first, fourth and eighth weeks, the heart parameters (HF, EF) were measured by echocardiography and then TNF-α factor was measured in the serum. Heart tissue was removed and the level of angiogenesis and fibrosis were investigated. Results: In the treated group with conditioned medium, the heart parameters (HF, EF) and angiogenesis increased significantly and decrease the level of TNF-α factor and fibrosis was significant in comparison with the Myocardial Infarction group (P<0.05). Discussion: Since the cardiac tissue and its function improved in this research, it seems that the secretion of bone marrow-derived mesenchymal stem cells have therapeutic effects on myocardial infarction. Manuscript profile
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  2 - Cardioprotective effect of Resveratrol on Isoproterenol-induced experimental myocardial infarction in rat
  daryoush mohajeri alireza monadi ghafour mousavi amirparviz Rezaei Saber
     Myocardial infarction affecting the mechanical, electrical, structural and biochemical properties of the heart, accounts for one of the causes of death in developed countries. The aim of this study was to evaluate the protective effects of resveratrol on is More

     Myocardial infarction affecting the mechanical, electrical, structural and biochemical properties of the heart, accounts for one of the causes of death in developed countries. The aim of this study was to evaluate the protective effects of resveratrol on isoproterenol-induced acute myocardial infarction in rats. For this purpose, fourty male Wistar rats were randomly allocated into four equal groups including: 1-control, 2-resveratrol treatment, 3-Isoproterenol treatment and 4-Isoproterenol plus resveratrol treatment groups. Isoproterenol (85 mg/kg) was administered at two consecutive days with 24h interval subcutaneously and resveratrol (20 mg/kg) was administered intraperitoneally for 30 consecutive days. Finally, blood samples were collected for measurement of cardiac biomarkers, creatinine kinase-MB (CK-MB) and lactate dehydrogenase. All animals were euthanized for histopathological examination and the assay for myocardial antioxidant status, by measurement of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels. Microscopically, myocardial tissues of the isoproterenol treated group showed severe degenerative and necrotic changes, while resveratrol alleviated myocardial necrotic damage. Levels of SOD, CAT and GPx decreased significantly (p<0.01) in the isoproterenol treated group, but increased significantly (p<0.05) in the isoproterenol plus resveratrol treatment group. Resveratrol significantly (p<0.05) decreased MDA levels which was increased by isoproterenol treatment. The results showed that resveratrol due to its antioxidant properties protects the cardiac tissue of rats from isoproterenol-induced ischemic damage.  Manuscript profile
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  3 - The Effect of Eight Weeks of Interval Training with Grape Seed Nanoparticles Supplementation on Bax and Bcl2 Gene Expression in the Heart Tissue of Myocardial Infarction Rats
  Hamid Mohammadi Hosseinabadi Khosro Jalali Dehkordi gholamreza sharifi Zohreh Mazaheri Tirani
  10.30495/varzesh.2021.1937861.1018
  Introduction: The use of exercise training and herbal supplements to treat diseases and metabolic disorders has become common among people. Considering the health-improving effects of aerobic training and grape seed nanoparticles extract, the present study was performed More

  Introduction: The use of exercise training and herbal supplements to treat diseases and metabolic disorders has become common among people. Considering the health-improving effects of aerobic training and grape seed nanoparticles extract, the present study was performed to investigate the effect of eight weeks of aerobic training with grape seed extract supplementation on Bax and Bcl2 gene expression in the heart tissue of rats with myocardial infarction.Materials and methods: In this experimental study, 20 rats were divided into four groups of five animals, including: 1) control, 2) aerobic training, 3) grape extract, and 4) training + grape extract. To investigate the effects of myocardial infarction on the study variables, five healthy rats were placed in the healthy control group. For eight weeks, groups 3 and 4 consumed 150 mg of grape extract daily by gavage. Also, groups 2 and 4 performed aerobic interval training, with 7 interval alternations, each including 4 minutes with an intensity of 80-90% VO2max and 3 minutes with an intensity of 65-75% VO2max. The Kolmogorov- Smirnov and one-way ANOVA with Tukey’s post- hoc tests were used to analyze the findings (P≥0.05).Findings: Induction of myocardial infarction had a significant effect on increasing Bax gene expression and decreasing Bcl2 gene expression in heart tissue (P≥0.001). However, aerobic training along with grape seed nanoparticle extract consumption had a significant effect on reducing Bax gene expression and increasing Bcl2 gene expression in the heart tissue of rats with myocardial infarction (P≥0.01).Conclusion: It seems that aerobic training along with grape extract consumption has more favorable effects on improving Bax and Bcl2 gene levels in myocardial infarction than either alone. Manuscript profile
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  4 - Investigating artificial neural networks versus regression models in predicting MI mortality based on climatic elements in Sanandaj
  Bromand Salahi Seyed Asaad Hosseini Kaweh Mohammadpour
  To analyze the relationship between mortality due to Myocardial Infarction (MI) with climatic parameters and its prediction, the ability of artificial neural network models, and linear and nonlinear regression in Sanandaj was evaluated. The dependent variable is the tot More

  To analyze the relationship between mortality due to Myocardial Infarction (MI) with climatic parameters and its prediction, the ability of artificial neural network models, and linear and nonlinear regression in Sanandaj was evaluated. The dependent variable is the total number of MI mortality. 54 months out of 60 in the sample period (2014-2018) were dedicated to training the ANNs model and, the remaining six months were given to test the ANNs model. By a selection of the monthly average temperature, a monthly average of maximum and minimum temperature, the average of the maximum and minimum air pressure measured at earth surface, the total number of sunny hours, and the number of days that their temperature is equal to or less than zero as input, a three-layer perceptron accompanied the didactic Levenberg-Marquardt algorithm and a hidden layer which contained 13 neurons and movable function of sigmoid tangent had the best possible output (the number of MI mortality). The results showed that in the relationship between the monthly MI mortality with the climatic parameters of Sanandaj, The relative error for multiple linear and nonlinear regression models is 22.3% and 22.1%, respectively, while for the ANNs model, it is 2.6%. The results also showed that according to the model error, using ANNs model as a nonlinear method in predicting and diagnosing the relationship between climatic parameters and mortality due to MI in Sanandaj could be considered an efficient and powerful tool in comparison with regression models. Manuscript profile
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  5 - An Efficient Artificial Intelligence Based Technique in Diseases Staging and Forecasting
  Negar Ahmadi Alfredo Milani
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  6 - Studying MiR-133 influencing the process of apoptosis of Cardiomyocytes floating in blood serum of patients suffering from acute Myocardial Infarction
  shiva kasiolkheir changiz ahmadizadeh hoshang hosseinzadeh mogbeli
  Abstract Background and goals: Myocardial Infarction is known as one of the most common disabling and threatening heart diseases resulted from irrevocable and degenerative cellular death in a part of heart muscle. After the discovery of miRNA in 1990 and the discovery o More

  Abstract Background and goals: Myocardial Infarction is known as one of the most common disabling and threatening heart diseases resulted from irrevocable and degenerative cellular death in a part of heart muscle. After the discovery of miRNA in 1990 and the discovery of more than 2500 types of miRNA, gradually the importance of these mechanism regulators and molecular signals and gene routes were identified in the processes and the cellular mechanisms, specifically in cardiovascular system. The goal of this research is Studying MiR-133 influencing the process of apoptosis of Cardiomyocytes floating in blood serum of patients suffering from acute Myocardial Infarction Methods: To achieve our goals in this case-observation study type regarding miR-133, 70 patients in Shahid Madani Hospital in Tabriz in the year 2017 were investigated by Real time PCR and the data were compared with those of the healthy persons. The statistical analyses were carried out using SPSS (version19) and a t-test method. The amounts for P>0.05 were considered meaningful. Findings: The expression levels of miR-133 among patients suffering from MI have had a considerable increase compared with control group and it was meaningful statistically. (P=0.009). Also the results showed that miR-133expression among fat and normal people did not have a meaningful difference statistically (P=0.06). Conclusion: The present study showed that the expression of miR-133among individuals suffering from MI has been greater than healthy people and it can be utilized as an identification factor and also prognosis of the patients suffering from MI. Manuscript profile
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  7 - اثرات محافظتی بتائین بر سکته قلبی ناشی از ایزوپرنالین از طریق apoE، Bcl-2 و عوامل آنتی اکسیداتیو در مدل موش صحرایی
  سروش قدرتی زاده قلی نژاد قلی نژاد محمد حسن خادم انصاری یوسف رسمی
  10.30495/jbcvm.2023.1973556.1034
  بتائین، یک مولکول چند عملکردی که دارای ویژگی حفاظت قلبی است ولی مکانیسم آن به خوبی مشخص نیست. لذا در این مطالعه ما به بررسی اثر بتائین بر بافت قلب و بیومارکرهای سرمی پرداختیم. بتائین در دوز های 50، 150 و 250 میلی گرم بر کیلوگرم بدن به موش های صحرایی آلبینو داده شد. سکته More

  بتائین، یک مولکول چند عملکردی که دارای ویژگی حفاظت قلبی است ولی مکانیسم آن به خوبی مشخص نیست. لذا در این مطالعه ما به بررسی اثر بتائین بر بافت قلب و بیومارکرهای سرمی پرداختیم. بتائین در دوز های 50، 150 و 250 میلی گرم بر کیلوگرم بدن به موش های صحرایی آلبینو داده شد. سکته قلبی با تزریق 100 میلی گرم بر وزن رت القا شد.  تست تانل و تست ایمنوهیستوشیمی به ترتیب برای بررسی آپوپتوز و سطح پروتئین نیتریک اکسید انجام شد. پراکسیداسیون لیپیدی و مقادیر آنزیم سوپر اکسید دیسموتاز با روش کالریمتری انجام شد.  بیان ژن های  آپوE و Bcl-2 در سلول های تک هسته ای خون محیطی با روش  RT-PCR تعیین شد. نتایج نشان داد که تجویز بتائین  در دوز 250 میلی گرم بر وزن بدن  به مدت 60 روز سبب کاهش آپوپتوز پس از سکته قلبی می شود (0/038>P). ژن Bcl-2 در بافت قلب در دوز 150 میلی گرم بر وزن بدن القا شده و نتایج مشابهی برای آپوE مشاهده شد. در حالیکه تغیراتی در مقادیر نیتریک اکسید مشاهده نشد اما پراکسیداسیون لیپیدی و سطوح آنزیم سوپر اکسید دیسموتاز کاهش یافت. نتایج مطالعه ما حاکی از آن است که بتائین به کمک Bcl-2 و ویژگی ضد استرس اکسیداتیو، سبب حفاظت قلب می شود. Manuscript profile
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  8 - Role of A2-adrenoceptors in Rat Heart with the Model of Myocardial Infarction
  Anna Mihailovna Kuptsova Roman Kutdusovich Bugrov Insaf Ilkhamovich Khabibrakhmano Roman Sergeevich Kobzarev Nafisa Ilgizovna Ziyatdinova Timur Lvovich Zefirov
  10.22034/jchr.2021.682031
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  9 - Investigation of the Level of Serum Troponin I and Comparing it with Serum CK-MB in Diagnosis of Myocardial Infarction
  جمال شمسی پریچهره یغمایی میرحسین سید محمدزاده سید علی حائری روحانی
  The Myocardial infarction (MI) is the fail in reaching blood flow and sufficient oxygen to part of the heart. Te outbreak of MI symptoms might be various and the electrocardiography is not diagnostic in about 50% of the cases that is a potential danger for wrong diagnos More

  The Myocardial infarction (MI) is the fail in reaching blood flow and sufficient oxygen to part of the heart. Te outbreak of MI symptoms might be various and the electrocardiography is not diagnostic in about 50% of the cases that is a potential danger for wrong diagnosis, therefore we need to test the cardiac biomarkers. In this survey the level of Troponin I serum in the diagnosis of the cardiac infarction with CK-MB serum, in 40 MI patients and 40 cardiac patients without MI of Seyyed Al Shohada Heart Hospital in Urmia has been evaluated and compared. the Troponin I through Immunoenzymometric method using AccuBind Kit and CK-MB through DGKC (German Society of Clinical Chemistry) method and IFCC (International Federation of Clinical Chemistry) using Pars Azmun Company kit through photometric method, measurement. and then Conducted  the results' statistical analysis using SPSS 21 software and an independent T-test The results achieved from the comparison between the cTnI and CK-MB of MI patients and patients without MI showed that there was a significant difference between the cTnI of patients without MI and MI patients and also the CK-MB of patients without MI and MI patients at the level of (P) and the cTnI and CK-MB of MI patients is more than patients without MI. therefore their use is necessary for on time diagnosis and treatment of Myocardial infarction. In this survey the cTnI and CK-MB was compared from the viewpoint of sensitivity and specification that regarding the results the cTnI sensitivity and specification with 100% and 97.5% respectively was more than the CK-MB sensitivity and specification with 91% and 75% respectively. Manuscript profile
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  10 - The Effect of Cardiac Preconditioning With Intense Intermittent Exercise on Tissue Levels of Hsp70 and SOD Enzyme Following Acute Myocardial Infarction in Male Rats
  abdollah bagheri Ahmad Hematfar mehdi Ruzbehani naser behpoor
  10.22034/ascij.2023.1982173.1476
  Sports training is considered as a tool to increase the protective power of the heart against stress.The aim of this study is to investigate the effect of pre-training with intense intermittent exercise on myocardial Hsp70 and SOD following acute myocardial infarction i More

  Sports training is considered as a tool to increase the protective power of the heart against stress.The aim of this study is to investigate the effect of pre-training with intense intermittent exercise on myocardial Hsp70 and SOD following acute myocardial infarction in male rats. 20 8-week-old male Wistar rats (with an average weight of 224.41±5.1 grams) were divided into 4 groups: control, exercise, stroke, and stroke-exercise. The training groups did two weeks of intense interval training in four sections. The first part, three days of training every day, two sessions, each day, and each session includes 4 intense intervals of two minutes at a speed of 35 to 40 meters per minute, and between each interval, a 2 minute active rest period at a speed of 25 to 30 meters per minute. Considered in the second part, two days of training, each day consisted of two training sessions containing 4 periods of intense activity of 2 minutes (40 to 45 m/min) and 3 periods of active rest of 2 minutes (28 to 32 m/min). The third part also included 5 intense periods (40 to 45 m/min) and 4 active rest periods (28 to 32 m/min) in three training days. The fourth part included two training days with the same intensity as the third part, but with an increase in activity and active rest in each session. Finally, Hsp70 and SOD were measured along with the amount of infarcted area. Heart damage enzymes (CK and LDH) were also measured in serum. The one-way analysis of variance test showed that two weeks of intense intermittent exercise, although it reduces the infarcted area of the heart of rats, but there were significant changes in Hsp70 and SOD after acute myocardial infarction between the stroke-exercise and stroke groups. Does not cause, while the measured heart damage enzymes (CK and LDH) showed a significant decrease in the stroke-exercise group compared to the stroke group. Therefore, two weeks of HIIT training can protect the heart from acute ischemia-induced damage through signaling pathways. Manuscript profile
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  11 - بررسی ارتباط بین سطح سرمی CRP با میزان مرگ و میر یک ماهه در بیماران مبتلا به سکته قلبی حاد در بیمارستان آریا در مدت یکسال
  Mohammad Sarafraz yazdi Mehrdad Sadeghi Ordubadi Ehsan Roshandel
  Introduction: acute myocardial infarction (AMI) is one of the most common diseases, affecting the industrialized and developing worlds with an annual prevalence of 650,000 in the United States alone. Acute myocardial infarction has a 30% mortality rate, and noting the More

  Introduction: acute myocardial infarction (AMI) is one of the most common diseases, affecting the industrialized and developing worlds with an annual prevalence of 650,000 in the United States alone. Acute myocardial infarction has a 30% mortality rate, and noting the importance of its complications many methods have been introduced to estimate the severity and prognosis of the disease. One serologic method is determining CRP, whose serum levels reflect the severity and involvement of acute cardiac muscle involvement. Till now many studies have looked at CRP as a predictor of prognosis in patients suffering from acute myocardial infarction, yet the results proved unsatisfactory in predicting short term mortality (1 month). In this study we will measure serum levels of hsCRP and compare it with their prognosis. Aim: to assess the relation between CRP serum levels with 1 month mortality of patients suffering from AMI. Materials and Methods: in this cross-sectional study blood samples were drawn from patients with chest pain and a diagnosis of AMI, 24 hours after admission to the CCU. The samples were mixed with either heparin or EDTA and were quickly sent to the lab and kept at 2-8 degrees Celsius for a maximum of 8 days (if frozen samples can be stored for up to 3 months). In the lab samples’ CRP forms a complex with anti-CRP polyclonal antibodies on latex and will cause turbidity. The amount of turbidity indicates the CRP level present in the sample. The relationship is calculated via enforced immunoturbidity after analysis with a two point photometer. The kit used in this study had a sensitivity of 0.1 to 20 mg/dl (Pars Kit Azmoon). Based on the kit used, the normal level in adults was considered below 5mg/dl. The patients were fallowed up 30 days post AMI. Results: 85 AMI patients were included in this study from which 15 expired within the first month after the infarction. Mean hsCRP levels in the deceased was 8.89, and in the survivors 6.39 mg/dl (P=0.146). Also 60% of the decease revealed high hsCRP (>5mg/dl), while in the survivors 45% revealed high hsCRP. Conclusion: considering other risk factors in the population under study which can increase a patient’s mortality risk, it can be said that hsCRP’s can play a relative role in predicting of 1 month prognosis of AMI patients. Moreover, this valuable index must be used alongside other risk factors for a precise estimation of prognosis in AMI patients.     Manuscript profile