List of Articles Kidney stone

• Open Access Article
  • Abstract Page
  • Full-Text
  
  1 - THE EFFECT OF HYDROPHILIC EXTRACT OF MUSA SAPIENTUM ON ETHYLENE‌ GLYCOLl-INDUCED RENA STONE IN MALE WISTAR RATS
  samira babai norozi Parastoo Rahimi mehdi rahnema
  Inroduction & Objective:Prevention of kidney stone formation is one of the important issues in preventing kidney disease. Banana’s peel has antioxidant, anti-inflammatory and tissue repairing properties, and due to its alkaline properties, it increases citrate More

  Inroduction & Objective:Prevention of kidney stone formation is one of the important issues in preventing kidney disease. Banana’s peel has antioxidant, anti-inflammatory and tissue repairing properties, and due to its alkaline properties, it increases citrate and decreases urinary calcium, urea and blood creatinine.Material and Method:In this study, 32 males of Wistar divided into 6 groups. Healthy control used only food and water, negative control group rats, used food, water, and 1% ethylene glycol solution. The control group 1, used food, water and solution of banana’s peel at concentrations of 100 mg / kg and 150 mg / kg orally. Experimental  1  used  food , water, and 100 kg concentration of banana's  skin extract solution  with 1% ethylene glycol .Experimental  2 rats, used  food , water,  solution of banana's peel extract at concentration of 150 mg / kg with 1% ethylene glycol solution. At the end   24 urine, blood kidneys of samples were collected. Kidney tissue was histological examined with hematoxylin-eosin for accumulation of calcium oxalate.Results: Significant differences were observed in creatinine and blood uric acid in the negative control group   compared to experimental 2.The highest urea levels in the blood were observed in the negative control Negative control had significant difference with experimental 1. Urea and urinary citrate in the negative control had significant difference compared to all groups. Urinary oxalate in the negative control  a statistically significant difference was observed compared to  healthy control .Also, the amount of crystals in  total renal tissue between experimental groups 1 and experimental group 2 with negative control group and other groups significant statistical differences were observed (P <0.05). Renal histological examinations showed improvement of renal tissue .Conclusion: The results show the effectiveness of banana peel extract on preventing kidney stones and improving tissue complications due to ethylene glycol consumption by inhibiting the formation of calcium oxalate due to its antioxidant and anti-inflammatory properties. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  2 - The Effect of Hydroalcoholic Extract of banana’s peel (Musa spaientum) on Rena Stone induced by Ethylene Glycol in Female Wistar rats
  Parastoo Rahimi Nastaran Ghassempoor
  Background and aim: Banana peel has antioxidant, anti-inflammatory, healing and tissue repair properties, and due to its alkaline properties, it increases citrate and decreases urinary calcium, urea, and blood creatinine. Material and Methods: In this study, the effect More

  Background and aim: Banana peel has antioxidant, anti-inflammatory, healing and tissue repair properties, and due to its alkaline properties, it increases citrate and decreases urinary calcium, urea, and blood creatinine. Material and Methods: In this study, the effect of hydroalcoholic extract of banana peel on kidney stone disease induced by ethylene glycol was tested in 42 female Wistar rats in 6 groups in 31 days. Healthy control used only food and water, negative control group rats, used food, water, and 1% ethylene glycol solution. The control group 1, used food, water and solution of banana’s peel at concentrations of 100 mg / kg and 150 mg / kg orally. Experimental 1 used food, water, and 100 kg concentration of banana's skin extract solution with 1% ethylene glycol .Experimental 2 rats, used food , water, solution of banana's peel extract at concentration of 150 mg / kg with 1% ethylene glycol solution.. At the end of, blood of samples were collected for biochemical analysis.Results: The results showed that creatinine, uric acid, and urea increased in the blood of the negative control group, and for creatinine and urea the difference between negative control and healthy control and experimental control 2 was significant. In the uric acid factor, despite the increase in the negative control, the differences are not significant (P<0.05).Conclusion: The results show the effectiveness of banana peel extract on kidney stones caused by ethylene glycol by inhibiting calcium oxalate formation pathways due to its antioxidant, anti-inflammatory and antibacterial properties. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  3 - Effect of Equaisetum arvense L. aerial parts of ethanolic extract on prevention of calcium oxalate crystals in kidney of male Wistar rats
  alireza sadeghipour ali mazooji
  Urolithiasis is a worldwide problem, sparing no geographical, cultural, or racial groups. Kidney stones are composed of inorganic and organic crystals amalgamated with proteins. Crystallisation and subsequent lithogenesis can happen with many solutes in the urine. Calca More

  Urolithiasis is a worldwide problem, sparing no geographical, cultural, or racial groups. Kidney stones are composed of inorganic and organic crystals amalgamated with proteins. Crystallisation and subsequent lithogenesis can happen with many solutes in the urine. Calcareous stones are still by far the most common nephroliths accounting for more than 80% of stones. In Iranian folk medicine, many plants are used for treatment of kidney stones. In the present study, effect of Equaisetum arvense L. aerial parts hydro-alcoholic extract on calcium oxalate crystallization was studied in male rats. At first, hydro-alcoholic extract of plant at doses of 25, 50 and 100 mg/kg were prepared. Crystallization of calcium oxalate was induced by adding ammonium chloride and ethylene glycol in drinking water for 3 and 38 days, respectively. Control group was treated by drinking water. Experimental groups were treated by plant extract at doses 25, 50 and 100 mg/kg for 41 days, interperitoneally. After 41 days, animals were anesthetized by ether and left kidneys removed and put them in buffered formaldehyde. Specimens were prepared for histological studies and stained by H&E staining method. Results showed that treatment of extract decreased number of crystals in kidney sections of experimental animals in comparison with control group. Also, administration of plant extract decreased tubule-interstitial damages in treated animals. So, the plant could prevent formation of calcium oxalate crystals in kidney. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  4 - Litholytic activity of hydro-alcoholic extract of Equisetum arvense L. in male rats
  maryam eidi Alireza Sadeghipour Ali Mazooji Reza Ghahramani
  In the present study, effect of Equisetum arvense aerial part hydro-alcoholic extracts on calcium oxalate crystallization was studied in male rats. At first, hydro-alcoholic extract of Equisetum arvense at doses of 25, 50 and 100 mg/kg were prepared. Crystallization of More

  In the present study, effect of Equisetum arvense aerial part hydro-alcoholic extracts on calcium oxalate crystallization was studied in male rats. At first, hydro-alcoholic extract of Equisetum arvense at doses of 25, 50 and 100 mg/kg were prepared. Crystallization of calcium oxalate was induced by adding ammonium chloride and ethylene glycol in drinking water for 3 and 38 days, respectively. Control group was treated by drinking water. Experimental groups were treated by extract at doses 25, 50 and 100 mg/kg for 38 days. After 38 days, animals were anesthetized by ether and left kidneys removed and put them in buffered formaldehyde. Specimens were prepared for histological studies and stained by H&E. Results showed that treatment of extract decreased number of crystals in kidney sections of experimental animals in comparison with control group. Also, administration of plant extract decreased tubule-interstitial damages in treated animals. Also, the extract decreased tubule-interstitial damages of tissue in treated animals. So, the treatment of plant could be confirmed by this research. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  5 - Effect of Coriandrum sativum seeds of ethanolic extract on prevention of kidney stone formation in male Wistar rats
  hosein ahmadian alireza Sadeghipour mostafa Hamidi nomani
  In the present study, effect of Coriandrum sativum L. seeds hydro-alcoholic extract on calcium oxalate crystallization was studied in male rats. At first, hydro-alcoholic extract of plant at doses of 100, 150, 200 and 300 mg/kg were prepared. Crystallization of calcium More

  In the present study, effect of Coriandrum sativum L. seeds hydro-alcoholic extract on calcium oxalate crystallization was studied in male rats. At first, hydro-alcoholic extract of plant at doses of 100, 150, 200 and 300 mg/kg were prepared. Crystallization of calcium oxalate was induced by adding ammonium chloride and ethylene glycol in drinking water for 3 and 35 days, respectively. Control group was treated by drinking water. Experimental groups were treated by extract at doses 100, 150, 200 and 300 mg/kg interperitoneally for 38 days. After 38 days, animals were anesthetized by ether and left kidneys removed and put them in buffered formaldehyde. Specimens were prepared for histological studies and stained by H&E. Results showed that treatment of extract decreased number of crystals in kidney sections of experimental animals in comparison with control group. Also, administration of plant extract decreased tubule-interstitial damages in treated animals. So, the plant could prevent formation of primary nucleus of kidney stones. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  6 - Effect of melon seed extract (Cucumis melo var. inodorous) on renal expression of osteopontin and lithostathin coding genes in urolithiatic male rats
  Maryam Eidi Mona Manouchehr-Mirza Mahdi Ebrahimi
  10.30495/jdb.2021.680724
  Kidney stone is one of the most important diseases of the urinary tract and the most important cause of death due to urinary tract disease. The prevalence of urinary tract disease is increasing and therefore more effective and low-risk therapies are needed for treatment More

  Kidney stone is one of the most important diseases of the urinary tract and the most important cause of death due to urinary tract disease. The prevalence of urinary tract disease is increasing and therefore more effective and low-risk therapies are needed for treatment. Melon seeds have been suggested for the treatment of kidney diseases such as kidney stones. The aim of the present study was to investigate the effect of hydro-ethanolic extract of melon seed on renal expression of osteopontin and lithostathin coding genes in male rats with kidney stones. Induction of calcium oxalate kidney stone was performed by oral treatment of ammonium chloride (3 days) and ethylene glycol (38 days) in male rats. Potassium citrate and hydro-ethanolic extract of melon seed were treated orally with ethylene glycol for 38 days. After 41 days, the animals were anesthetized and their right kidney was removed for evaluation of renal expression of osteopontin and lithostathin coding genes by real-time PCR. Results showed that daily oral administration of potassium citrate and extract (150, 300 and 600 mg/kg body weight) significantly increased the expression of osteopontin coding gene (spp1) in experimental rats compared to control group (p <0.001). Also, daily oral administration of potassium citrate and extract significantly increased lithostathin coding gene (reg1a) expression in experimental rats compared to control group (p < 0.001). In conclusion, melon seed extract can improve kidney stone disease by enhancing the expression of osteopontin and lithostathin-encoding genes and is more effective than potassium citrate in treating the disease. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  7 - Fractionation and In vitro Evaluation of Prunus persica Pulp Extract against Urolithasis
  Hema Arya Gautam Kumar Vandana . Minakshi Pandey
  The peach tree “Prunus persica” is widely cultivated in India, and its fruits which have been used for centuries in traditional Indian medicine, are also known as the Queen of the Fruits. Prunus persica has immense therapeutic potential, widespread use in folklore and a More

  The peach tree “Prunus persica” is widely cultivated in India, and its fruits which have been used for centuries in traditional Indian medicine, are also known as the Queen of the Fruits. Prunus persica has immense therapeutic potential, widespread use in folklore and ancient systems of medicine for its anti-urolithic and other medicinal properties, and is included in the Pashanbheda group of herbs mentioned in Ayurveda for the treatment of kidney stones. Moreover, with growing interest in phytopharmaceuticals in the present world, there always remains an urge for a comprehensive understanding of the phytochemicals responsible for the medicinal activity of herbal drugs, giving rise to the importance of conducting bioassay-guided fractionation. In this study, the anti-urolithiasis activity of different fractions of Prunus persica fruit extracts was evaluated via Nucleation, Aggregation, and Growth assays, and fraction III showed the highest effects in vitro. This study provides a pharmacological basis for using Prunus persica fruit extract in treating kidney stones. Manuscript profile