Effect of Coriandrum sativum seeds of ethanolic extract on prevention of kidney stone formation in male Wistar rats

Subject Areas : animal development

hosein ahmadian ¹ , alireza Sadeghipour ² , mostafa Hamidi nomani ³

1 - Young Researcher’s Club, Varamin Branch, Islamic Azad University, Varamin, Iran
2 - Oncology Center, Tehran Medical Science University, Tehran, Iran
3 - دانشگاه آزاد اسلامی، واحد ورامین – پیشوا، دانشکده علوم زیستی، گروه زیست شناسی، ورامین – پیشوا، ایران

Received: 2021-09-15 Accepted : 2021-09-17 Published : 2021-02-19

Keywords: Rat, Crystallization, Calcium oxalate, Kidney stone, ndrum sativum,

Abstract :

In the present study, effect of Coriandrum sativum L. seeds hydro-alcoholic extract on calcium oxalate crystallization was studied in male rats. At first, hydro-alcoholic extract of plant at doses of 100, 150, 200 and 300 mg/kg were prepared. Crystallization of calcium oxalate was induced by adding ammonium chloride and ethylene glycol in drinking water for 3 and 35 days, respectively. Control group was treated by drinking water. Experimental groups were treated by extract at doses 100, 150, 200 and 300 mg/kg interperitoneally for 38 days. After 38 days, animals were anesthetized by ether and left kidneys removed and put them in buffered formaldehyde. Specimens were prepared for histological studies and stained by H&E. Results showed that treatment of extract decreased number of crystals in kidney sections of experimental animals in comparison with control group. Also, administration of plant extract decreased tubule-interstitial damages in treated animals. So, the plant could prevent formation of primary nucleus of kidney stones.