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Open Access Article
1 - Effects of thymol on atheroma plaque, concentration of blood lipids and atherogenic indices serum in male NMRI mice fed with a high-cholesterol diet
Karkhaneh, L., Yaghmaei, P.*, Ebrahim-Habibi, A., Parivar, K., Sadeghizadeh, M. .Atherosclerosis is characterized by the accumulation of fat and inflammatory response in the artery intima and can cause narrowing or complete blockage of the artery. Thymol is a phenolic monoterpene with antioxidant and anti-inflammatory properties. The aim of this stu MoreAtherosclerosis is characterized by the accumulation of fat and inflammatory response in the artery intima and can cause narrowing or complete blockage of the artery. Thymol is a phenolic monoterpene with antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effects of thymol on blood lipids, atherogenic indices and atheroma plaque of NMRI mice fed a high-cholesterol diet (HCD). 45 NMRI male mice were divided into 5 groups (n=9): Animals of the control group received a normal diet. Whiles in the HCD group received a diet containing 2% cholesterol for 18 weeks. Animals of the sham group received HCD for 12 weeks and then normal diet for 6 weeks with a thymol solvent (oil). The experimental groups 1 and 2 received HCD for 12 weeks and then received a normal diet with thymol at doses of 12 mg/kg and 24 mg/kg for 6 weeks, respectively. At the end of study, concentration of serum lipids and atherogenic indices were measured. Also aorta was measured microscopically. In the present study, consumption of HCD resulted in the formation of atheroma plaque, increased serum triglycerides, total cholesterol concentration, atherogenic indices and significantly decreased high density lipoprotein cholesterol (HDL-C). Treatment with both doses of thymol significantly reduced these changes and improves blood lipids, atherogenic indices was normal and atheroma plaques. The results of this study suggest that thymol can be used for treatment of increased total cholesterol and triglycerides and to improve the atheroma plaque. Manuscript profile -
Open Access Article
2 - Association of Limbs Lenghts and Circumferences, Waist to Hip Ratio, BMI and other Body Dimensions with Lipid Profile and Blood Glucose
Mohsen Jafari alireza abdollahi nahid bizhehBackground: Health professionals are seeking simple methods for evaluation of atherosclerosis risk. The aim of this study was determination of relationship between body dimensions with atherosclerosis risk factors. Methods: Subjects of this study were inactive middle-ag MoreBackground: Health professionals are seeking simple methods for evaluation of atherosclerosis risk. The aim of this study was determination of relationship between body dimensions with atherosclerosis risk factors. Methods: Subjects of this study were inactive middle-aged men (n=102) and women (n=77). Anthropometric indices (size, breath and circumferences of body segments), lipid profile (blood cholesterol, triglyceride, highdensity lipoprotein and low density lopoprotein) and blood glucose of the subjects were determined using standard methods. Results: Waist circumference, hip circumference, waist to hip ratio (WHR), waist to thigh ratio (WTR), waist to height ratio (WHtR), trunk size, second to fourth digit ratio, suprailiacus skinfold fat and subscapularis to triceps skinfold ratio (STR) in men and body mass index (BMI), waist circumference, hip circumference, trunk size, second and fourth digit lengths, triceps and suprailiacus skinfold fat and WHtR in women were significantly related to the risk of dyslipidemia (P≤0.05). Conclusion: Hip circumference, suprailiacus skinfold fat and WHtR in both sexes have positive relationship with the risk of atherosclerosis. Waist circumference, WTR and WHR in men and BMI in women have stronger correlation with atherosclerosis. Manuscript profile -
Open Access Article
3 - The Effect of Magnetic Nanoparticles on Dynamic Behavior of Aorta Artery with Atherosclerosis Under the Action of Pulsating Blood Velocity
M.R Motaghedifar A Fakhar H Tabatabaei M Mazochi -
Open Access Article
4 - The effect of eight weeks of aerobic training and Anethum herbal supplementation on lipid risk factors for cardiovascular disease in inactive obese men
Ardeshir Zafari Taher Jalili -
Open Access Article
5 - The effect of eight weeks of continuous-resistance training on lipid profile and body composition of overweight women
keyvan hejaziBackground and purpose: Lipid profiles play an important role in the pathogenesis of atherosclerosis. We aimed to investigate the effect of eight weeks of continuous-resistance training on lipid profile and body composition of overweight women.Material and Methods: In t MoreBackground and purpose: Lipid profiles play an important role in the pathogenesis of atherosclerosis. We aimed to investigate the effect of eight weeks of continuous-resistance training on lipid profile and body composition of overweight women.Material and Methods: In this semi-experimental study, 24 overweight women were randomly assigned to control (n=12) and experimental (n=12). The program training include: 80-90 min per session, 3 times per week for 8 weeks participate in continuous-resistance. Blood samples were collected 24 hours before training and 48 hours after training session. To make intra and intergroup comparisons t-test for dependent and independent samples were used. Results: Levels of triglycerides, total cholesterol, and low-density lipoprotein decreased significantly, while levels of high-density lipoprotein increased significantly. Body weight and body mass index values decreased significantly at the end of the period.Conclusion: Eight weeks of continuous-resistance training resulted in improved lipid profile and body composition at the end of the training period. Therefore, the results of our research suggest that a continuous-resistance training program can improve the health of overweight women. Manuscript profile -
Open Access Article
6 - Effects of Eight Weeks of High-Intensity Interval Training (HIIT) on the Expression of GPR120 and AMPK Proteins in the Heart Tissue of Diabetic Male Rats
Ebrahim Hoseini Houri pasand Saeid Dabbagh Nikoo Kheslat Javad VakiliThe reverse cholesterol transfer process has a positive role in reducing atherosclerotic plaques during diabetes. Therefore, the aim of the present study was to evaluate the effect of eight weeks of high-intensity interval training on GPR120 and AMPK proteins in the car MoreThe reverse cholesterol transfer process has a positive role in reducing atherosclerotic plaques during diabetes. Therefore, the aim of the present study was to evaluate the effect of eight weeks of high-intensity interval training on GPR120 and AMPK proteins in the cardiac tissue of mice with type 2 diabetes. In an experimental study, 40 three-month-old adult male Wistar rats with an average weight (250-300 g) were randomly divided into four groups of 10 series including: healthy control (C: intraperitoneal injection of saline), healthy training (T: running at 85-90 % of maximum speed in 6 to 12 bouts in two-minute periods; 5 days per week for eight weeks), diabetic control (D: diabetic on a high-fat diet with intraperitoneal injection of streptozotocin) and trained diabetics (D+T: diabetic with training) were divided. A method based on Western blotting was used to determine changes in the expression profile of GPR120 and AMPK proteins in the heart muscle tissue (left ventricle) of rats. The two-way analysis of variance and Bonferroni post hoc test were used to analyze the data. Induction of diabetes (D) significantly reduced GPR120 and AMPK proteins (p ≤ 0.05). While HIIT training apply in healthy group (T) increased 81% and 47% in GPR120 and AMPK compared to diabetic control group (D) respectively (p = 0.001). Also, training intervention has the ability to prevent a decrease in both of proteins in the trained diabetic group (D+T) compared to the diabetic group (D) (p = 0.023). Based on the findings of this study, it can be stated that eight weeks of high-intensity interval training (HIIT) is a preventive strategy against reducing the activity of GPR120 and AMPK proteins involved in the reverse cholesterol transmission during type 2 diabetes. Manuscript profile -
Open Access Article
7 - Comparative Effect of Simvastatin with Methanolic Extract and Hyoscyamoside Extracted from Hyoscyamus niger Plant on APO A Gene Expression in Wistar Atherosclerosis Male Rats
Ronak Abdolmohammadi Maryam Bananej Maryam Khosravi Hengameh AlibeikAtherosclerosis is a chronic inflammatory disease of the artery that is mainly known by arterial wall thickening. The use of medicine herbs with minimal side effects in hypercholesterolemia treatment and removal of atherosclerotic plaque is important. The aim of the pre MoreAtherosclerosis is a chronic inflammatory disease of the artery that is mainly known by arterial wall thickening. The use of medicine herbs with minimal side effects in hypercholesterolemia treatment and removal of atherosclerotic plaque is important. The aim of the present study was to investigate the comparative effect of simvastatin with methanolic extract and hyoscyamoside extracted from Hyoscyamus niger plant on APO A gene expression in Wistar atherosclerosis male rats.Forty Wistar male rats weighing approximately 180 gr (at the beginning of the experiment) were prepared and randomly divided into 5 groups including 8 (control, sham, experimental 1, 2 and 3). All groups (except control) received fatty foods (1% cholesterol) in addition to 2% cholesterol for 40 days (receiving saline water 1 mg/kg daily by control group during this period). Then, the three experimental groups were treated daily with 40 mg/kg of simvastatin, 25 mg/kg of hyoscyamoside and 25 mg/kg of methanolic extract of Hyoscyamus niger plant for 28 days, respectively. During the treatment, sham group received 1 mg/kg saline water daily. Finally, APO A gene expression was determined by blood sampling with real-time PCR tecnique in leukocytes. Also, serum lipid levels were measured by photometric method. Methanolic extract and Hyoscyamus niger plant extracted-hyoscyamoside and simvastatin were caused a significant increase in APO A gene expression in all three experimental groups compared to sham group. Also, methanolic extract was more effective than other products in increasing this gene expression. Methanolic extract of Hyoscyamus niger plant and extracted hyoscyamoside have an additive effect on APO A gene expression and increase serum HDL levels. Manuscript profile -
Open Access Article
8 - Effects of Combined Extracts of Allium sativum and Citrus limon on Atherosclerosis Inflammatory Risk Factor (hs-CRP) in Male Wistar Rats under High-fat Diet
P. Baradaran Khalkhali S.A. Haeri Rouhani P. YaghmaeeCardiovascular disease, which includes atherosclerosis, is one of the major diseases in the world. High sensitive C-reactive protein is the most sensitive inflammatory marker that recently its serum level predicts risk of cardiovascular disease is suggested. Both garlic MoreCardiovascular disease, which includes atherosclerosis, is one of the major diseases in the world. High sensitive C-reactive protein is the most sensitive inflammatory marker that recently its serum level predicts risk of cardiovascular disease is suggested. Both garlic (Allium sativum) and lemon (citrus limon) are used in the traditional management of CVD without a scientific evidence of the benefit of their combination. This study designed to investigate the hypolipidemic and anti-inflammatory effects of combined extracts of A. sativum and C. limon in male Wistar rats after high-fat diet for eight weeks. For this purpose, 42 adult male rats of Wistar strain, with weights between 200 and 250 gr, were divided into six groups (n=7). Group control and Exp3 was fed on normal pellet diet while group control fat, Sham, Exp1 and Exp2 fed on high-fat diet for up to 8 wk. The combined extract was administered to rats in graded doses for 4 wk and blood serum was analyzed for C-reactive protein and total cholesterol.Results are expressed as means ± SE. Significance differences of biochemical measurements were analyzed by using repeated measure and ANOVA tests to identify differences in phases and among groups. When appropriate, a Tukey posthoc was applied. Statistical significance was accepted at PA. sativum and C. limon was recognizable. However, future long-term well-designed investigations would provide valuable information to establish public health recommendations on the combined extract, taking into account both the nature of the compounds and the optimal dose, for cardiovascular health protection Manuscript profile
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