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Open Access Article
1 - مطالعه اثر کود های اوره، فسفات کلسیم ، سولفات پتاسیم و هم افزایی آنها بر تولید برگ و پاجوش در گیاه آلوئه ورا
احد مدنی مرتضی عباسی فرشید مدنی -
Open Access Article
2 - The Effect of Ethanol Extraction of Aloe vera on Certain Biomarkers of Cardiovascular Disease in Mice Treated with Nanoparticles of Titanium Dioxide
Fereshteh Javan Masoomi Jila Talat Mehrabad Roghayeh Babri BonabInroduction & Objective: The effect of ethanol extraction of Aloe vera on certain biomarkers of cardiovascular disease in mice treated with titanium dioxide nanoparticles was studied.Material and Methods: Mice were received titanium dioxide nanoparticles with density of MoreInroduction & Objective: The effect of ethanol extraction of Aloe vera on certain biomarkers of cardiovascular disease in mice treated with titanium dioxide nanoparticles was studied.Material and Methods: Mice were received titanium dioxide nanoparticles with density of 100 milligrams per kg and ethanol extraction of aloe vera plant with density of 100, 200 and 300 milligrams per kg for 30 days. Plasma levels ofmalondialdehyde, rich sialic acid, troponin I and creatine kinase MB at the end of treatment was evaluated. The antioxidant activity of ethanol extraction in Aloe Vera using free radical DPPH and total phenol levels were considered.Results: The results showed that giving titanium dioxide nanoparticles through the stimulation of oxidative activity had a significant increase in plasma levels of malondialdehyde (MDA). Plasma levels of troponin I, creatine kinase MB and rich sialic acid also significantly increased. With increasing density of aloe vera, the total phenol and antioxidant activity of ethanol extraction increased. Giving the extraction significantly reduced the plasma levels of biomarkers of cardiovascular damage in mice treated with titanium dioxide nanoparticles.Conclusion:According to the results, ethanol extraction of aloe vera as an antioxidant compound is able to reduce the levels of cardiovascular damage in mice treated with titanium dioxide nanoparticles. Manuscript profile -
Open Access Article
3 - Evaluation Of the Effects Of Different Concentrations Of Aloe veraExtract on the Proliferation Of Uterus Cervical Cancer Cells(Hela)Of Humans
Elahe Ebrahimi Masoud Parsania Hamid Hosseini dostInroduction and Objective: Cervical cancer is the second most common cancer in womenHigh incidence ofcerviccancer and the side effects of the treatments with synthetic chemical compounds demonstrated that hazards are immense.Considering the side effects, treatment with MoreInroduction and Objective: Cervical cancer is the second most common cancer in womenHigh incidence ofcerviccancer and the side effects of the treatments with synthetic chemical compounds demonstrated that hazards are immense.Considering the side effects, treatment with extracts of plants such as Aloe vera have proved to be reducing the levels of side effects and can bemuch cheaper alternative. So, anti cancer properties of the extracts of Aloe vera against the Hela cells of humanwas evaluated in tissue culture, in this study.Material and Methods:After gatheringand confirmthe desiredplant species.Extractionwas performed bymacerationThe toxicity effects of different concentrations 16,17,18,19, 20 and 21 mg/ml of extract of Aloe veraon the Hela cells of human, were evaluated using Trypan blue and MTT methods,on 24, 48 and 72 hours after exposure to a mediumcontaining 1serum and extractResults: 20 mg/ml concentration ofAloe veraextract was toxical effects on Hela cells of human based on the results obtained, it was concluded that extracts of Aloe verainhibit the proliferation of Hela cells of human Manuscript profile -
Open Access Article
4 - Collagen Turnover in Healing of Cutaneous Wounds by Aloe vera Fresh Gel in Mouse: Involvement of Fibroblast Growth Factor Receptor
Mehran Arabi homeira JafarzadehInroduction & Objective: Using herbal products like Aloe vera (Aloe barbadensis Miller) plays an important role in wound healing. This study aimed to evalutea the curative influence of Aloe vera (AV) fresh gel on healing of open cutaneous wounds in mouse. Material MoreInroduction & Objective: Using herbal products like Aloe vera (Aloe barbadensis Miller) plays an important role in wound healing. This study aimed to evalutea the curative influence of Aloe vera (AV) fresh gel on healing of open cutaneous wounds in mouse. Material and Method: Mice were 1) pseudo-control (sham): wound treated with physiological serum; 2) wound treated with 2 gr AV fresh gel. Two equal full-thickness skin wounds were made on vertebral column in the sacral region. On 8th and 16th post wounding day, skin sampling for the purpose of gene expression of fibroblast growth factor receptor (FGF-R) under RT-PCR evaluation was taken place. Urine samples were used to determine the concentration of hydroxy proline (HP) as a marker of collagen turnover in wounds, using HP assay kit. Results: AV fresh gel could up-regulate the expression of FGF-R gene as compared to negative and pseudo-controls (P<0.05). In addition, HP concentration was incresed in AV gel-treated groups comparing to others. Conclusion: We revealed that AV fresh gel was capable of healing wounds via elevation in collagen turnover and represents a good candidate for a wound healing process in human and animals. Manuscript profile -
Open Access Article
5 - The effect of green silver nanoparticles on spinach (Spinacia oleracea) seed germination under salt stress
Amin Ali Naghi Zadeh Mehrnaz Mahmoudi Zarandi Sayed Mohammad Reza Khoshroo Fatemeh Hasan ZadehSalinity is one of the most important abiotic stresses for plants and its adverse effects on different stages of plant growth and yield have been reported. Salinity can reduce seed germination as the most sensitive stage of plant growth. The use of silver nanoparticles MoreSalinity is one of the most important abiotic stresses for plants and its adverse effects on different stages of plant growth and yield have been reported. Salinity can reduce seed germination as the most sensitive stage of plant growth. The use of silver nanoparticles has been suggested to improve the germination of some plants in salinity conditions. On the other hand, consuming spinach is highly recommended due to its high nutritional value. In this study, aloe vera extract was used for synthesis of silver nanoparticles. Then, the effects of salinity on seed germination of spinach and the role of silver nanoparticles on seed germination indices in this plant were investigated. The formation of silver nitrate nanoparticles was investigated using a spectrophotometer, XRD analysis, and electron microscopy. Spherical nanoparticles, with an average size of 11.97 nm to 29.46 nm were observed. Treatments in a completely randomized design with three replications of green silver nanoparticles at concentrations of 10, 20, 40, 80 and 100 ppm and salinity at four levels of 0, 50, 100 and 150 mM on spinach seed germination process were investigated . The results showed that the germination process under salinity conditions decreased significantly compared to the control group. Treatment of 40 ppm concentration of silver nanoparticles for different levels of salinity had a significantly increased effect on germination indices at 1% level . Manuscript profile -
Open Access Article
6 - Effects of Aloe vera extract on growth rate of Barbus grypus
معصومه صفری مژده چله مال مهرزاد مصباحIn this study, the effect of Sabrzard extract (Aleo vera) on growth of Shyrbot (Barbus grypus) were investigated. For this purpose three concentrations of Aloe vera extract, 0.1, 0.2 and 0.5% (in triplicate) were mixed with the feed and the fish were fed with this MoreIn this study, the effect of Sabrzard extract (Aleo vera) on growth of Shyrbot (Barbus grypus) were investigated. For this purpose three concentrations of Aloe vera extract, 0.1, 0.2 and 0.5% (in triplicate) were mixed with the feed and the fish were fed with this diet for 60 days. Control group was fed with the control diet without Aloe vera extract. Growth parameters include weight gain, percent of weight gain, increase of length, condition factor, feed consumption, feed conversion, specific growth rate, protein efficiency ratio and food efficiency were measured. Results indicated that feeding Shyrbot with Aloe Vera extract 0.2% lead to significant increase in the quality index, percent of weight gain, specific growth rate and weight gain (P<0.05). Also feeding with extract 0.5% lead to increase of quality index (P<0.05). Effect of oral administration of different doses of Aloe vera on feed conversion, protein efficiency ratio, feed efficiency comparison between treatments and control group was different significantly (P<0.05). Altogether we can say that the better doses of Aloe vera in diet for growth excitement and blood parameters are 0.2 and 0.5%. Manuscript profile -
Open Access Article
7 - The Effect of Eight- Weeks Aloe Vera Consumption and Aerobic Training on Serum Vaspin, Glucose and Serum Insulin in Women with Type 2 Diabetes
Amir Maleki Shahin Riyahi Malayeri Talie Eghbali -
Open Access Article
8 - Study of effects of different plant growth regulators on explant's establishment of Aloe vera (Aloe barbadensis Mill.)
A.B Barzgar مرضیه Shafiee HajiAbad محمود AbdyAloe (Aloe barbadensis Mill) is one of the most important medicinal plants belonging to Liliaceae family that nowadays is propagated by in vitro culture in high-scale propagation. Because of the impotance of the establishment stage in in vito culture of this plant, this MoreAloe (Aloe barbadensis Mill) is one of the most important medicinal plants belonging to Liliaceae family that nowadays is propagated by in vitro culture in high-scale propagation. Because of the impotance of the establishment stage in in vito culture of this plant, this study was conducted to investigate the best media culture for Aloe explants establishment. First, the prolifration rate of two kind of explants (Shoot tips and auxiliary buds) were evaluated on 8 media cultures and shoot tips selected as the best explants. Then, in order to determine the best media culture an experiment was conducted in factorail design with two factors: auxins in four levels (1 mgl-1 IAA, 0.5 mgl-1IAA, 1 mgl-1IBA, 0.5 mgl-1IBA) and cytokinins in two levels (BA and Kinetin at 1 mgl-1) in a complete randomised design with 3 replications. After 35 days the highest rate of prolifration earned on the media contained 0.5 mgl-1 IAA and 1 mgl-1 BA with 6.0 shoots per explant and 2.3 cm length, that is higher and faster than other related reports. Since on the stablishment stage of in vitro culture regnaration of the highest shoot number per explant with small size has considerable attention, this protocol suggestes an appropriate method for establishment of Aloe explants. Manuscript profile -
Open Access Article
9 - Potential applications of Aloe vera L. in the pharmaceutical, cosmetic, health, and food industries - nanoparticle biosynthesis: a comprehensive review
Mohammad Heydari Tayebeh Tabatabaie Fazel Amiri Seyed Enayat HashemiAloe vera L. is one of the oldest and most traditional medicinal plants in history, which is more than a thousand years old. Today, its biological activity is not limited to therapeutic purposes. The expansion of the Aloe vera L. industry became evident during the 90s w MoreAloe vera L. is one of the oldest and most traditional medicinal plants in history, which is more than a thousand years old. Today, its biological activity is not limited to therapeutic purposes. The expansion of the Aloe vera L. industry became evident during the 90s when the development of this product began due to the global demand from consumers for a healthier lifestyle. Considering this plant's relationship with agriculture, industry, and the economy, the present work examined chemical, biological, and nutritional properties of Aloe vera and its processing methods, innovations, and biosynthesis of nanoparticles, and industrial applications. Applications of this plant are detailed in pharmaceutical, cosmetic, and food industries, and the global vision of the million-dollar market around this product is discussed. Also, the biosynthesis method of nanoparticles using Aloe vera L. as a reducing agent is presented. Aloe vera L. has been used to produce nanomaterial through biosynthesis. This plant has many unique properties and is known for its antioxidant, anti-inflammatory, anti-diabetic, sunburn relief, immune system strengthening, anti-aging, and anti-cancer properties. The study concludes that biosynthesized nanoparticles with Aloe vera L. are environmentally friendly, simple, economical, and safe. Manuscript profile -
Open Access Article
10 - بررسی اثر اشعه ی UV-C و تنظیم کننده های رشد گیاهی بر آلوئه ورا ( Aloe vera L )
نسترن صادقی مرضیه شفیعی حاجی آباد امیر مهدی شوکتیمقدمه و هدف: اثرات اشعه­ی فرابنفش بر گیاهان که به نور خورشید نیاز دائمی دارند، غیر قابل اجتناب است. تأثیر مستقیم نور فرابنفش بر رشد و نمو در گیاهان، معمولاً منفی است و گیاهان ساز و کارهای دفاعی مختلفی برای محافظت و سازگاری خود به کار می­گیرند. این تحقیق با Moreمقدمه و هدف: اثرات اشعه­ی فرابنفش بر گیاهان که به نور خورشید نیاز دائمی دارند، غیر قابل اجتناب است. تأثیر مستقیم نور فرابنفش بر رشد و نمو در گیاهان، معمولاً منفی است و گیاهان ساز و کارهای دفاعی مختلفی برای محافظت و سازگاری خود به کار می­گیرند. این تحقیق با هدف بررسی اثرات مخرّب، محرک یا سازنده­ی احتمالی اشعه­ی UV-C (nm 280 - 100) بر گیاهچه­های درون شیشه­ای آلوئه­ورا و تغییرات احتمالی این اثرات در حضور غلظت­های مختلف تنظیم کننده­های رشد موجود در محیط کشت، انجام گرفته­است. روش تحقیق: گیاه آلوئه ورا به این دلیل انتخاب شد که گیاهی دارویی و نیمه­ گرمسیری است و به طور معمول در محل کشت و پرورش خود به طور مداوم در معرض اشعههای فرابنفش انرژی خورشید قرار دارد. تیمارهای مورد آزمون شامل محیط کشت در 4 سطح و اشعه­ی UV-C در دو سطح (40 میکرووات بر سانتی­متر مربع و صفر میکرووات بر سانتی­متر مربع) بودند. گیاهچه­های درون­شیشه­ای روی 4 محیط کشت مختلف در 6 تکرار کشت شدند و 3 تکرار از آن­ها طی 1 ماه، روزانه 1 ساعت در معرض اشعه­ی UV-C قرار گرفتند.نتایج و بحث: نتایج حاصل از این بررسی نشان داد که بیش­ترین طول گیاهچه، تعداد و طول ریشه در محیط کشت، دارای5/1 میلی­گرم در لیتر IBA و بیش­ترین تعداد شاخساره در محیط کشت، دارای 5/1 میلی­گرم در لیتر IBA و 1 میلی­گرم در لیترBA به دست آمد. اشعه­ی UV-C به طور معنی­داری باعث کاهش طول اندام­های هوایی، تعداد و طول ریشه در تیمارهای اشعه دیده شد اما تعداد شاخساره را افزایش داد. توصیه کاربردی/صنعتی: براساس نتایج به­دست آمده از این تحقیق، اشعه­ی UV-C باعث کاهش تعداد و طول ریشه شد. بنابراین استفاده از این اشعه در مراحل ریشه­زایی و طویل شدن اندام­های هوایی در گیاه آلوئه ورا توصیه نمی­شود. این در حالی است که در محیط­های استقرار و پرآوری اشعه­ی UV-C می­تواند به عنوان عاملی برای تحریک تولید شاخساره­ی بیش­تر در کشت درون­شیشه­ای به کار رود. Manuscript profile -
Open Access Article
11 - اثرات کاربرد آلومینوسیلیکات زئولیت بر صفات مورفولوژیک و ترکیبات شیمیایی گیاه دارویی آلوئه ورا (Aloe vera L) در شرایط تنش خشکی
سارا یاری پژمان مرادی فرحناز خلیقی سیگارودیمقدمه و هدف: امروزه آلوئه­ورا در صنایع غذایی و دارویی بسیار مورد توجه قرار گرفته است. هدف از این پژوهش بهبود رشد رویشی، افزایش تولید متابولیت‎های ارزشمند گیاهی و افزایش قندهای موجود در ژل آلوئه ورا با صرف هزینه‎ پایین و بازدهی بالا در شرایط تنش آبی است. روش Moreمقدمه و هدف: امروزه آلوئه­ورا در صنایع غذایی و دارویی بسیار مورد توجه قرار گرفته است. هدف از این پژوهش بهبود رشد رویشی، افزایش تولید متابولیت‎های ارزشمند گیاهی و افزایش قندهای موجود در ژل آلوئه ورا با صرف هزینه‎ پایین و بازدهی بالا در شرایط تنش آبی است. روش تحقیق:در این تحقیق، کشت گلدانی آلوئه ورا در شرایط گلخانه ای و با اعمال 4 سطح زئولیت 0، 11، 22 و 44 گرم در 5 کیلوگرم خاک گلدان، درسه تکرار انجام شد. گلدان ها به مدت 5 ماه در معرض سه سطح مختلف تیمار آبیاری قرار گرفتند. تیمارها عبارت از آبیاری با فاصله هفته ای یک بار، 2 هفته یک بار و 3 هفته یک بار بود. در نهایت صفات مورفولوژیک، هم­چنین میزان باربالوئین تولیدی و قندهای مختلف در این گیاه توسط دستگاه کروماتوگرافی مایع با کارآیی بالا (HPLC) مورد سنجش قرار گرفت. داده­ها با استفاده از نرم افزارآماریMSTATC تجزیه و تحلیل شدند. مقایسه میانگین صفات توسط آزمون چنددامنه­ای دانکن در سطح احتمال 05/0مورد ارزیابی قرار گرفتند. نتایج و بحث:در بررسی اثرات ساده و متقابل کاربرد زئولیت و اعمال تیمارهای مختلف آبیاری، بهترین نتایج صفات مورفولوژیکی مختلف با کاربرد 22 گرم زئولیت در 5 کیلوگرم خاک گلدان و آبیاری 3 هفته یک بار به دست آمد. بیشترین میزان ماده مؤثره باربالوئین در تیمار اثرات متقابل 44 گرم زئولیت در 5 کیلوگرم خاک گلدان و آبیاری هفته ای یک بار مشاهده شد و بالاترین میزان قندها با کاربرد 44 گرم زئولیت در 5 کیلوگرم خاک گلدان و آبیاری 2 هفته یک بار حاصل شد. توصیه کاربردی/صنعتی: آلومینوسیلیکات زئولیت در بهبود خصوصیات مورفولوژیک، افزایش ماده مؤثره باربالوئین و افزایش سطح پلی ساکاریدهای موجود در ژل گیاه آلوئه ورا در شرایط تنش آبی دارای نقش مؤثری است. Manuscript profile -
Open Access Article
12 - اثرات نعناع و آلوئه ورا بر جمعیت میکروفلورای ایلئوم و عملکرد رشد در جوجههای گوشتی در مقایسه با آنتیبیوتیک محرک رشد
ب. دارابیقانع ف. میرزایی آقچه قشلاق ب. نوید شاد ع. مهدوی ا. زارعی س. ناهاشوناین تحقیق به منظور مقایسه اثرات دو گیاه دارویی (نعناع و آلوئه ورا) و آنتیبیوتیک محرک رشد بر جمعیت میکروفلورای ایلئوم و عملکرد رشد در جوجههای گوشتی انجام گردید. در این آزمایش از 375 قطعه جوجه یکروزه نر (راس 308) در قالب طرح کاملاً تصادفی با 5 تیمار و هر تیمار شامل 5 تک Moreاین تحقیق به منظور مقایسه اثرات دو گیاه دارویی (نعناع و آلوئه ورا) و آنتیبیوتیک محرک رشد بر جمعیت میکروفلورای ایلئوم و عملکرد رشد در جوجههای گوشتی انجام گردید. در این آزمایش از 375 قطعه جوجه یکروزه نر (راس 308) در قالب طرح کاملاً تصادفی با 5 تیمار و هر تیمار شامل 5 تکرار و 15 جوجه در هر تکرار استفاده شد. تیمارهای آزمایشی شامل: 1) جیره شاهد ( جیره پایه بدون هیچ افزودنی)، 2) جیره پایه + 10 گرم/کیلوگرم برگ خشک شده نعناع، 3) جیره پایه + 10 گرم/کیلوگرم ژل آلوئه ورا، 4) جیره پایه + 5 گرم/کیلوگرم برگ خشک شده نعناع + 5 گرم/کیلوگرم ژل آلوئه ورا و 5) جیره پایه + 10 پیپیام آنتیبیوتیک ویرجینیامایسین بودند. پارامترهای عملکرد رشد برای دورههای آغازین، رشد و پایانی و جمعیت باکتریهای لاکتوباسیلوس و اشرشیاکلی در روز 42 مورد ارزیابی قرار گرفتند. بیشترین تعداد باکتریهای لاکتوباسیلوس در ایلئوم جوجههای تغذیه شده با خوراک حاوی مخلوط برگ خشک شده نعناع و ژل آلوئه ورا مشاهده شد (05/0>P). جوجههای دریافتکننده مکمل گیاهان دارویی، کمترین جمعیت اشرشیاکلی را در مقایسه با جوجههای شاهد داشتند (05/0>P). جوجههای تغذیه شده با آنتیبیوتیک خوراک مصرفی، افزایش وزن بدن و درصد لاشه بیشتری نسبت به جوجههای شاهد و جوجههای تغذیه شده با گیاهان دارویی را بدست آوردند و جوجههای تغذیه شده با گیاهان دارویی خوراک مصرفی، افزایش وزن بدن و درصد لاشه بالاتری نسبت به جوجههای شاهد را دارا بودند (05/0>P). جوجههای تغذیه شده با خوراک حاوی مخلوط برگ خشک شده نعناع و ژل آلوئه ورا عملکرد رشد و درصد لاشه بهتری را داشتند. این مطالعه بیانگر آن است که استفاده از مخلوط برگ خشک شده نعناع و ژل آلوئه ورا بعنوان مکمل خوراک جوجههای گوشتی میتواند جایگزینی برای آنتیبیوتیک محرک رشد باشد. Manuscript profile -
Open Access Article
13 - Design and manufacture of electrospun wound dressing based on polyvinylpyrrolidone fibers modified with aloe vera compounds for the treatment of skin edema
seyedeh Shadi Amini Dehkordi Nargess Aghamohamadi Javad Shabani ShayehIn this research, a new type of wound dressing based on polyvinyl pyrrolidone polymer (PVP) modified by extracted compounds from aloe vera (Av) was prepared by electrospinning method. After achieving optimal preparation conditions using experimental design method, the p MoreIn this research, a new type of wound dressing based on polyvinyl pyrrolidone polymer (PVP) modified by extracted compounds from aloe vera (Av) was prepared by electrospinning method. After achieving optimal preparation conditions using experimental design method, the prepared material was characterized using infrared Fourier transform spectroscopy, scanning electron microscopy, X-ray diffraction, differential scanning calorimetry analysis, and thermogravimetric analysis. The results of the studies showed that by using the optimal conditions, smooth filament of PVP without node with the diameter of about 100 nm can be achieved. PVP-Av and PVP-Av-Film fiber diameter as well as fibers with a special therapeutic coating were about 105 and 120 nm, respectively with a suitable surface to volume ratio. The results of the investigations showed that the use of polymer coating on the wound dressing not only increase its mechanical resistance, but also increase the hydrophilicity of this wound dressing. In addition, the results of biological investigations showed that this wound dressing has very little toxicity for biological cells and can be used to treat skin edema. Manuscript profile -
Open Access Article
14 - Effect of Aloe vera Extract on Spermatogenesis and Reproductive Hormones in Mice
مهرداد مدرسی حمیدرضا خدائی علیرضا خدادادیAloe with the scientific name Aloe vera is a perennial plant that has useful effects in herbal therapy and herbal medicine. In this research the effects of hydroalcoholic extract of Aloe vera gel on the testis and spermatogenesis in mice Balb/C mice were examined. Sampl MoreAloe with the scientific name Aloe vera is a perennial plant that has useful effects in herbal therapy and herbal medicine. In this research the effects of hydroalcoholic extract of Aloe vera gel on the testis and spermatogenesis in mice Balb/C mice were examined. Samples randomly divided into five groups (three treatment groups, placebo and control) and all samples were kept in the same conditions. Aloe vera gel extract in different doses (50, 100 and 200 mg/kg/2day) produced by intraperitoneal (IP) for 20 days was administered to the treatment group. Placebo group was used as the injection of saline. The main parameters that were examined changes in levels of testosterone, LH and FSH levels and changes in stem cell number, number primary spermatocytes, and testis weight compared with the control group. All of hormonal experiments using Radioimmunoassay (RIA) were performed.The results showed that Aloe vera extract caused a significant increase in the number of stem cells and primary spermatocytes in the experimental group compared with the control group. Mean of testicular weights and testosterone levels in group 3 (200 mg/kg) increased significantly, while LH and FSH levels did not show significant changes. The findings indicate Aloe vera extract in a dose-dependent effect on testosterone levels and histological characteristics of male mice. Manuscript profile -
Open Access Article
15 - The Effect of Gelatin-aloevera Nanofibers on Collagen I Gene Expression in the Skin of Male Mice after Microneedling
Asadolah Shahrani Maryam Bananej Parvin Mansouri Henghameh Alibeik Nahid NickhahThe skin is prone to mechanical injuries and damage and the skin collagen changes with age. Herbs and aloe vera gel are used experimentally and traditionally in the skin repair and rejuvenation. In this study, the effect of gelatin-aloe vera nanofibers on the expression MoreThe skin is prone to mechanical injuries and damage and the skin collagen changes with age. Herbs and aloe vera gel are used experimentally and traditionally in the skin repair and rejuvenation. In this study, the effect of gelatin-aloe vera nanofibers on the expression of collagen I gene after skin microneedling was investigated in male mice under standard laboratory conditions. Skin microneedling was performed on the backs of the tested mice. Groups were subjected to treatments with saline, aloe vera gel, and gelatin-aloe vera nanofibers for 48 h. The expression of collagen I gene was evaluated through sampling and purification of tissue RNA by Real time PCR method. According to the results, skin injury resulted in a significant reduction in the expression of the collagen I gene in the treatment groups compared to the control group. In comparison, treatment with aloe vera gel and aloe vera/gelatin nanofibers significantly increased gene expression compared to the model group. Furthermore, the existing Glucomannan increased gene expression at the site of injury by passing through pores. Manuscript profile
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