List of Articles حسین عابدنطنزی

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  1 - The effect of Endurance Training on Oxidative Stress Induced by Ischemia in Male Rat Heart
  ali ojaghi farshad ghazalian Tohid Vahdatpour Hossein Abednatanzi Reza badalzadeh
  DOR: 20.1001.1.17359880.1400.14.3.8.9
  Inroduction & Objective: Regular exercise reduces the incidence of cardiovascular diseases. In this context, choosing the type and intensity of training as a suitable model for further effectiveness is essential. The aim of this study was to investigate the effect o More

  Inroduction & Objective: Regular exercise reduces the incidence of cardiovascular diseases. In this context, choosing the type and intensity of training as a suitable model for further effectiveness is essential. The aim of this study was to investigate the effect of 8 weeks of endurance training on oxidative stress induced by ischemia in male rats.Materials and Methods: In this study, thirty two male Wistar rats in the weight range of 220± 20g were used. After one week of adaptation to the new environment, mice were randomly divided into four groups (n=8): 1- Control group, 2- Isoproterenol group (ISO), 3- Endurance exercise group (EnEx) 4- Endurance exercise group + Isoproterenol (EnEx + ISO). EnEx and EnEx + ISO groups were undergoing endurance training for 8 weeks. At the end of the eighth week of training, Isoproterenol (85 mg / kg) was administered intraperitoneally for 2 consecutive days. Then, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and malondialdehyde (MDA) were measured with special kits. Results: Results showed that cardiac ischemia significantly decreased antioxidant enzymes and increased lipid peroxidation (MDA) as compared to control and exercise groups, while eight weeks of endurance training before ischemia increased antioxidant enzymes activity and decreased the level of MDA in comparison to ischemia group.Conclusion: The results of this study showed that endurance training can have a therapeutic effect against ischemia-related injuries by reducing oxidative stress and diminish ischemic heart disorders. Manuscript profile
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  2 - The effect of HIIT and thyme honey on gene expression of cardiac tissue apoptotic indices and insulin resistance index in type 2 diabetic rats
  bahareh behaeen Hossein َAbedntanzi mandana gholami farshad ghazalian
  Inroduction & Objective: Type 2 diabetes is the most common endocrine disease that can cause damage and cell death or apoptosis. The aim of this study was to investigate the expression of apoptotic and anti-apoptotic gene of heart tissue and insulin resistance index More

  Inroduction & Objective: Type 2 diabetes is the most common endocrine disease that can cause damage and cell death or apoptosis. The aim of this study was to investigate the expression of apoptotic and anti-apoptotic gene of heart tissue and insulin resistance index after intense intermittent exercise and consumption of thyme honey in diabetic type 2 rats. Materials and Methods: The statistical population consisted of rats. After 20 weeks of high fat diet and injection of STZ became diabetic. Rats in 4 groups: control(n=6),HIIT(n= 8),thyme honey(n= 6),HIIT-thyme honey (n=8) trained HIIT for eight weeks, five sessions per week with intense 2-minute intense alternation with 2 to 8 alternations and with 80 to 90% vo2max and one-minute rest alternation with 50 to 56% vo2max.Thyme honey was given by gavage at a rate of 3g/kg 5days a week. Glucose, insulin and expression of Bax and Bcl2 genes and their ratio was calculated. Statistical analysis was performed using two-factor analysis of variance test and determining the effect size and Bonfroni post hoc.Results: HIIT and thyme honey decreased Bax gene expression and increased Bcl2 expression in heart cells (P<0.05). HIIT and thyme honey in diabetic rats led to improved glucose and insulin levels and decreased insulin resistance index. It also decreased the expression of Bax gene and increased the expression of Bcl2 (P<0.05). Conclusion: HIIT with thyme honey led to improved glycemic profile and changes in glucose and insulin levels, as well as positive and appropriate changes in the expression of cardiac and anti-apoptotic genes.  Manuscript profile
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  3 - The effect of endurance training and consumption of nettle extract on the gene expression of BCL-2 and TNF-α in mice with melanoma
  lila mosavi barari barari asieh Abbasi Daloii hossien Abed Natanzi
  Inroduction & Objective: : Melanoma is the most serious type of skin cancer, which is made up of melanin pigment cells.The aim of this study was to evaluate the effect of endurance training and nettle consumption on BCL-2 and TNF-α gene expression in mice with More

  Inroduction & Objective: : Melanoma is the most serious type of skin cancer, which is made up of melanin pigment cells.The aim of this study was to evaluate the effect of endurance training and nettle consumption on BCL-2 and TNF-α gene expression in mice with melanoma.Material and Methods: The subjects included male Wistar rats that after two weeks of adjustment were randomly divided into 4 groups including: control, exercise, extract and exercise + extract. Exercise program included 30 minute of running on a treadmill was steep and at a speed of 16 meters per minute for the first week, and every week one meter per minute was added until the eighth week it reached 22 meters per minute. One week after melanoma induction, the experimental group consumed 30 mg / kg / day of nettle ethanol extract orally for 8 weeks. RT PCR was used to measure gene expression.Results: Data analysis showed that consumption of nettle extract and endurance training significantly reduced the expression level of BCL-2 and TNF-α genes in mice with melanoma in different groups (p = 0.000, p = 0.025, respectively). The results also showed that the difference in the level of changes in BCL-2 and TNF-α gene expression between the exercise and extract group with the control group (p = 0.002, p = 0.014, respectively) was significantly reduced.Conclusion: Regular physical activity combined with consumption of nettle extract can probably reduce anti-apoptotic factors and cause apoptosis in cancer cells by reducing inflammatory factors. Manuscript profile
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  4 - Comparison the effect of one period of anaerobic and resistance training on some metalloproteins affecting heart fibrosis in elderly mice
  Fatemeh Ghalambor Hossein َAbedntanzi mandana gholami Farshad Ghazalian
  20.1001.1.17359880.1401.15.4.5.5
   Introduction & Objective: Aging causes structural changes in the heart that are associated with an increased risk of cardiovascular disease. The aim of this study was to compare the effect of a period of aerobic and resistance training on some metalloproteins More

   Introduction & Objective: Aging causes structural changes in the heart that are associated with an increased risk of cardiovascular disease. The aim of this study was to compare the effect of a period of aerobic and resistance training on some metalloproteins that affect heart fibrosis in elderly mice.Materials & Methods: For the present experimental study, 27 male Wistar rats with an average age of 24 months were prepared from the center of Pasteur Institute and after weighing were randomly divided into 3 groups: control, resistance training and low intensity aerobic training. Then, the aerobic training group started training for 12 minutes with an intensity of 12 meters per minute in the first week, and at the end of the eighth week, the time reached 52 minutes and the intensity was constant. The resistance training group did 8 repetitions in the first week with 5% of body weight and in the eighth week the intensity reached 40% of body weight. Sampling was performed 48 hours after the last training session.Results: results showed that there was a significant difference between the effect of aerobic and resistance training methods on MMP-2 and the percentage of collagen deposition in the heart tissue of elderly mice. But there is no significant difference between the effect of two training methods on MMP-9.Conclusion: According to the results, the use of aerobic and resistance training on heart fibrosis is recommended in consultation with a physician, which is more recommended on the use of resistance training. Manuscript profile
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  5 - The effect of eight weeks of HIIT and N-chromosome royal jelly on liver enzymes and insulin resistance index in type 2 diabetic obese rats
  sahar Riasati Hossein Abednatanzi Mandana Gholami
  Background & Aim: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand, which leads to be changes in liver enzymes with structural and functional changes in the liver. The aim of More

  Background & Aim: Type 2 diabetes is the most common endocrine disease that occurs due to glucose intolerance due to imbalance between reserves and insulin demand, which leads to be changes in liver enzymes with structural and functional changes in the liver. The aim of this study was to study changes in liver enzymes and insulin resistance index after HIIT and royal jelly in obese rats with type 2 diabetes. Materials & Methods: The statistical sample of the present study was 36 obese male rats with an average weight of 409 gr. After 20 weeks of high-fat diet, rats became diabetic by intraperitoneal injection of 25 mg/kg STZ body weight. Mice with fasting glucose between 150 and 400 mg /dl were considered to have type 2 diabetes. Diabetic rat in 4 groups of control (N=6), HIIT (N=8), royal gel (N=7), HIIT& Royal gel (N=8) group done and Accomplished Eight weeks of HIIT, 5d/w with intense 2-minute intervals of 80 to 90% VO2max and one-minute rest intervals with 50 to 56% VO2max. Royal jelly was given by gavage at the rate of 100 mg / kg 5 days a week. At the end of the protocol, blood samples were taken and liver enzymes and glucose were measured using an auto-analyzer and insulin was measured using a laboratory kit and analyzed using one-way and two-way analysis of variance and post hoc test. Results: showed that in comparison with the control group, HIIT led to a significant decrease in glucose and insulin resistance index and intermittent exercise resulted in a decrease in liver enzymes ALT, AST and ALP compared to the control group. The ALP decrease was significant (P = 0.001). Conclusion: It seems that HIIT and consumption of royal jelly can help reduce liver enzymes and improve liver status in rats. Manuscript profile