Comparison the effect of one period of anaerobic and resistance training on some metalloproteins affecting heart fibrosis in elderly mice

Subject Areas :

Fatemeh Ghalambor ¹ , Hossein َAbedntanzi ² , mandana gholami ³ , Farshad Ghazalian ⁴

1 - Department of Physical Education and Sports Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of physical education and sport science, Science and research branch, Islamic Azad University, Tehran, Iran.
3 - Department of Physical Education and Sport Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran
4 - Department of Physiology, Faculty of Physical Education and Sport Sciences, Azad University, Research Sciences Branch, Tehran, Iran

Received: 2022-06-01 Accepted : 2022-07-17 Published : 2022-11-22

Keywords: Resistance training, metalloprotein, Fibrosis, Aerobic training,

Abstract :

 Introduction & Objective: Aging causes structural changes in the heart that are associated with an increased risk of cardiovascular disease. The aim of this study was to compare the effect of a period of aerobic and resistance training on some metalloproteins that affect heart fibrosis in elderly mice.Materials & Methods: For the present experimental study, 27 male Wistar rats with an average age of 24 months were prepared from the center of Pasteur Institute and after weighing were randomly divided into 3 groups: control, resistance training and low intensity aerobic training. Then, the aerobic training group started training for 12 minutes with an intensity of 12 meters per minute in the first week, and at the end of the eighth week, the time reached 52 minutes and the intensity was constant. The resistance training group did 8 repetitions in the first week with 5% of body weight and in the eighth week the intensity reached 40% of body weight. Sampling was performed 48 hours after the last training session.Results: results showed that there was a significant difference between the effect of aerobic and resistance training methods on MMP-2 and the percentage of collagen deposition in the heart tissue of elderly mice. But there is no significant difference between the effect of two training methods on MMP-9.Conclusion: According to the results, the use of aerobic and resistance training on heart fibrosis is recommended in consultation with a physician, which is more recommended on the use of resistance training.