The Role of CB1 Receptors on Central Food Intake Regulation in ad libitumfedLayer-type Chicken
Subject Areas :
Abbas
Alizadeh
1
(بخش فیزیولوژی، گروه علوم پایه، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران. ایران.)
Morteza
Zendehdel
2
(بخش فیزیولوژی، گروه علوم پایه، دانشکده دامپزشکی دانشگاه تهران، تهران. ایران)
Vahab
Babapour
3
(بخش فیزیولوژی، گروه علوم پایه، دانشکده دامپزشکی دانشگاه تهران، تهران. ایران)
Saeid
Charkhkar
4
(بخش فیزیولوژی، گروه علوم پایه، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران. ایران.)
Shahin
Hassanpour
5
(بخش فیزیولوژی، گروه علوم پایه، دانشکده دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران. ایران.)
Keywords: food intake, Canna Binoidergic, Layer-Type Chicken,
Abstract :
Inroduction & Objective: Mechanisms that regulate appetite are different among animals. Also, nutritional status (food deprived or satisfied) has key role on appetite regulation. Endocannabinoids have crucial role on central food intake regulation in birds but its role has not been studied in layer-type chicken fed ad libitumThus, in this study 3 experiments designed to evaluate effects of intracerebroventricular (ICV) administration of 2-AG (2- Arachidonoylglycerol, selective CB1 receptors agonist), SR141716A (selective CB1 receptors antagonist), on feeding behavior in neonatal layer-type chickens fedad libitumMaterial and Methods:In experiment 1, birds ICV injected with control solution and 2-AG (0.25, 0.5 and 1 μg). In experiment 2: control solution, SR141716A (6.25, 12.5 and 25 μg) were ICV injected to birds. In experiment 3 animals received: control solution, SR141716A (6.25 μg), 2- AG (1 μg) and co-injection of SR141716A+2-AG. Then, cumulative food intake was recorded until 120 min after injection.Results: According to the results, 2-AG dose dependently increased cumulative food intake while SR141716A reduced appetite compared to control group (PConclusion:These results suggest CB1 receptors have an important role on ingestive behavior in neonatal layer-type chicken fedad libitum and nutritional status (food deprived or satisfied) had no effect on food intake induced by CB1 receptors in chicken.