Inroduction & Objective:The aim of this study was to investigate the effects of eight weeks of aerobic exercise and chlorella supplementation on renal antioxidants in diabetic rats. Materials and Methods:50 male adult wistar rats were randomized into healthy control, diabetic control, training, supplement (chlorella) and training-supplementation(synergistic intervention) groups and the diabetes induced using intraperitoneal injection of sterptozocin (STZ). Throughout the intervention period, chlorella extract was consumed daily with the dosage equal to 5% of body weight prior to the morning meal for eight weeks and the training was included on treadmill running for 5 days/week (on a smart automated animal device). The data were compared using two way factorial and one way ANOVA. Results: In all groups the higher superoxide dismutase (SOD) and catalase (CAT) activities as well as lower body weight compared to healthy controls were remarkable following to intervention period (P<0.05), however; all three interventions diminished the diabetes induced increases in the activity of these enzymes as well as body weight reductions (P<0.05). Furthermore, while there were no between group differences in the effects from training, chlorella supplementation or synergistic intervention upon SOD activity, however; the synergistic effect was better than both them to diminish diabetes induced changes in CAT activity and/or body weight. there is no significant differences were observed in plasma glucose level in between the training and synergistic intervention groups with healthy controls, while a significant difference were demonstrated for these two groups compared to chlorella group (P<0.05). Conclusion: These elevated enzymes activities could probably attributable to the amelioration of the oxidative stress by the organism in the kidneys and the higher lipid peroxidation and hazardous effect from diabetes on kidneys. However; because of the lack of similar evidences and some methodological limitations in this study, more research remains to be done in this area.
Manuscript profile
