Natural marine products are a source of new drugs
Subject Areas : Journal of Quality and Durability of Agricultural Products and Food Stuffs
Lida Shojaei kavan
1
(Assistant Professor, Natural Resources Department, Savadkooh Branch, Islamic Azad University, Savadkooh, Iran
Community Verified icon)
Keywords: marine natural products, Inflammation, cancer, Infectious diseases, Alzheimer', s,
Abstract :
Natural products from plants, animals, microbes and minerals have long been a traditional source for treating human diseases. Recent advances in analytical, spectroscopic, and high-throughput screening technology have greatly revived the discovery of natural drugs, including the contribution of marine products-based drugs. The marine environment is a unique resource that contains enormous biological diversity and may potentially lead to successful treatments. An increasing number of compounds from marine sources are entering clinical trials, and thus, the field's impact on the pharmaceutical industry is increasing. Marine organisms are excellent producers of natural chemicals with diverse structures and pharmacological activities. Most of the new products being produced from the sea are anti-tumor, anti-inflammatory and anti-infectious products. Invertebrates and seaweeds are diverse and at the same time rich sources of biologically active substances for the production of new drugs. Despite all the efforts made to isolate new drugs from the sea, due to the obstacles in the way of the mass production of these drugs, including the limitation of the reserves of marine organisms, the cultivation and propagation of these organisms and the isolation of medicinal substances from them, in the realm of experience and The test remains. However, according to the progress of science, marine medicines have a very bright perspective and will lead to the creation and expansion of effective treatment methods in the medical field in the near future.
Refrences
1-David B. Jean-Luc Wolfender JL. Dias DA. The pharmaceutical industry and na-tural products: historical status and new trends. Phytochem Rev. 2015; 14(2): 299-315.
2-Martins A. Vieira H. Gaspar H. Santos S. Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success Mar Drugs. 2014; 12(2): 1066-1101. *Marketed mar-ine natural product based drugs reviewed
3 Kanase HR. Singh KM. Marine pharma-cology: Potential, challenges, and future in India, Journal of Medical Sciences. 2018; 38(2): 49-53.
4-Zhang Z. Chen M. Chai W. Lian X. Zhe-jiang University. Preparation of Strepto-mycesfulvissimus acid and Streptomyces-fulvissimus ketone and medicinal appl-ication thereof. CN107619803A, 2018 *discloses novel compounds inhibiting propagation of different brain glioma cells.
5-Jianhua J. Yongxiang S. Jie Li; Huang HongboSouth China Sea Institute of Oce-anology Chinese Academy of Sciences. New angucycline compounds useful in pr-eparing drugs for inhibiting bacterial infe-ction and treating cancer CN104744533A. 2017.
6-Jianhua J. Yongxiang s, Hongbo H. Zha-ng Yun. South China Sea Institute of Oce-anology Chinese Academy of Sciences, A Class phenazine compounds and its appl-ication in preparing antineoplastic medi-caments CN103360329A. 2015.
7-Wang F. Zhang Si. Huang Zhi. Tian Xin Li J. South China Sea Institute of Ocea-nology Chinese Academy of Sciences. Su-lfur-containing diindolyl diketopiperazine compounds and application thereof in pre-paring antineoplastic drugs CN102911188 A, 2015.
8-Zhou T and Zhou G. Xining Yige Inte-llectual Property Consulting Services Co. New sesquiterpene quinine compound in dysidea avara and application thereof CN104478688A. 2015.
9-Shujuan P. Houwen L. Haiyan L. Fan Yang et.al. Shanghai Changzheng Hosp-ital, Dimeric Sesterterpenoids useful for preventing, diagnosing, detecting, prote-cting, treating and researching e.g. tumor, diabetes and obesity CN102617596A, 2016.
10-Yoichi N. Shigetaka A. Daisuke A. Yukari K. Teppei S. Waseda University and Yakult Honsha Co Ltd, Marine orga-nism-derived extract, compound, and me-dical composition having niche formation suppressing activity of leukemic stem cells WO2017122736A1, 2017.
11- Ma Z. Ding H. Ding W. Zhang D. et.al. Hangzhou Kexing Biochem Co. Ltd., Compound with BRD4 inhibition activity, and preparation method and application of compound CN106883113A, 2017.
12-Negi B. Kumar D and Rawat DS. Marine Peptides as Anticancer Agents: A Remedy to Mankind by Nature. Curr Pro-tein Pept Sci. 2017; 18(9):885-904.
13-Zheng L. Sun M. Chen S. Yi Y. et.al. Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences, Bacillus sp.N11-8 and active component thereof having antitumor action CN 103667097, 2015.
14-Cai X. Shandong Tianwang Pharmace-utical Technology Co. Ltd., Marine bioa-ctive composition and pharmaceutical pre-paration CN106668077A. 2017.
15-Zheng C. Huang G. Chen G. Bai M et.al. Hainan Normal University, Mangr-ove fungus derived chloroanthraquinone compound and application of mangrove fungus derived chloroanthraquinone com-pound serving as antibacterial agent CN-106631803A. 2017. Accepted Manuscript
16-Zheng C. Huang G. Chen G. Zheng C et.al. Hainan Normal University, Isocou-marin compound with anti-vibrio activity function and crystal thereof CN 10643 2169A. 2017.
17-Choi HJ. Chang HW. Kim G J. Lee X. Univ Yeungnam Res Coop Found. Novel marine Bacillus sp. compounds isolated from the marine Bacillus sp. and pharm aceutical use of the compounds. KR 2017003180 A. 2017.
18- She Z. Huang X. Ma L. Long Y. Sun Yat-sen University, Sesterterpine compo unds, and preparation method and appli-cation thereof CN102936252. 2015.
19-Vijayakumar M. Priya K. Noorlidah A et.al. Cardioprotective activity of polysa-ccharides derived from marine algae: An overview. Trends Food Sci. Technol. 2013; 30(2): 98-104. Accepted Manuscript
20-Guili C. Weihai Lanyin Marine Biote-chnology Co. Ltd., Medicine composition with compound marine biological polysa-ccharides, method for preparing medicine composition and application thereof CN-106389827 .2017.
21-Xu L. Qingdao Haoda Marine Health Food Co. Ltd., Marine health capsule with blood lipid regulating function CN-105031314 .2015.
22-Ankisetty S. Slattery M. Antibacterial Secondary Metabolites from the Cave Sponge Xestospongia sp. Mar. Drugs 2012; 10, 1037-1043.
23-Rahman H. Austin B. Mitchell W.J. and et.al. Novel Anti-Infective Compo-unds from Marine Bacteria. Mar. Drugs 2010; 8, 498-518.
24-Li Chunyan. Wang Xin Li. Xinhe, Qingdao Hifun Marine Biological Techn-ology Co. Ltd., Degerming eye lotion containing marine organisms CN-104548077.2015.
25-Dalian Shenlantai Technology Resea-rch And Development Co. Ltd., Sea cucu-mber enzymatic hydrolysate eyedrops and preparation method thereof CN106109499 .2016.
26-Jun-Hyeong Park. Seong-Hun Choi. Soo-Jin Park and et.al. “Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Accepted Manuscript Dermal Excision Rat Model” Mar. Drugs 2017; 15(4): 112. https: //doi.org/10.3390/md15040112.
27-Venkatesan J. Kim S-K. Marine Algae Derived Polysaccharides for Bone Tissue Regeneration. In ‘Marine Algae Extracts’. (Ed.^(Eds pp. 509-522. (Wiley-VCH Verlag GmbH & Co. KGaA). http: //dx.doi.org/10.1002/9783527679577.ch30.
28-Matthew A. Carson and Susan A. Clarke Bioactive Compounds from Mar-ine Organisms: Potential for Bone Growth and Healing. Mar Drugs. 2018 Sep; 16(9): 340. https://doi.org/10.3390/md16090340.
29-Innocent J. M and Besim Ben-Niss-an.Marine Skeletons: Towards Hard Tis-sue Repair and Regeneration. Mar Drugs. 2018; 16(7): 225. doi: 10.3390 / md 16070225. 30-Dalian Shenlantai Techn-ology Research And Development Co. Ltd., A daily consumption of the drug treatment of cervical spondylosis CN 107929713 .2018.
31-Dalian Shenlantai Technology Resea-rch And Development Co. Ltd., Drug treatment of osteoporosis based marine polysaccharides CN107823634 .2018.
32-Hannam University Institute For Indu-stry-Academia Cooperation, Pharmace-utical composition for preventing or trea-ting osteoporosis comprising sea algae extract as active ingredient KR1692292 .2017.
33-Shandong Weikang Biomedical Tech-nology Co. Ltd., Marine organism cream for treating osteoarticular disease CN 105288560 .2016.
34-Weihai Terence Biological Enginee-ring Co. Ltd., Glucosamine increases cucumber seed formulation and produ-ction method of BMD CN104888192 .2018.
35-Fan Yu-mei. Pure natural traditional Chinese medicine and marine organism active immunization bone CN106421926 .2017.
36-Wang Wen-jin. Trepang and oyster enzymolysis oral liquid and preparation method thereof CN105341933 .2016.
_||_