محصولات طبیعی دریایی منبع داروهای جدید
محورهای موضوعی : فصلنامه کیفیت و ماندگاری تولیدات کشاورزی و مواد غذایی
لیدا شجاعی کاوان
1
(استادیار گروه منابع طبیعی، واحد سوادکوه، دانشگاه ازاد اسلامی، سوادکوه، ایران)
کلید واژه: التهاب, محصولات طبیعی دریایی, بیماری های عفونی, سرطان, آلزایمر,
چکیده مقاله :
محصولات طبیعی از گیاهان، حیوانات، میکروب ها و مواد معدنی از دیرباز منبع سنتی برای درمان بیماری های انسانی بوده است. پیشرفت‌های اخیر در فن‌آوری تحلیلی، طیف‌سنجی و غربالگری با توان عملیاتی بالا ؛کشف داروهای طبیعی، از جمله سهم داروهای مبتنی بر فرآورده های دریایی را به‌شدت احیا کرده است. محیط زیست دریایی، یک منبع منحصر به فرد است که تنوع بیولوژیکی عظیمی را در بر می گیرد و ممکن است به طور بالقوه منجر به درمان های موفقیت آمیز گردد. تعداد فزاینده‌ای از ترکیبات منابع دریایی، وارد آزمایش‌های بالینی می‌شوند و بنابراین، تأثیر این رشته بر صنعت داروسازی در حال افزایش است. موجودات دریایی، تولیدکنندگان عالی مواد شیمیایی طبیعی با ساختارها و فعالیت های دارویی متنوع هستند. اغلب فرآورده های جدید در حال تولید از دریا، فراورده های ضد توموری، ضد التهابی و ضد بیماریهای عفونی می باشند. بی مهرگان و جلبک های دریایی، منابعی متنوع و در عین حال سرشار از مواد زیستی فعال جهت تولید داروهای جدید محسوب می شوند. علی رغم کلیه تلاش های صورت گرفته در جهت جداسازی داروهای جدید از دریا، به دلیل موانع موجود بر سر راه تولید انبوه این داروها از جمله محدودیت ذخایر موجودات دریایی، کشت و تکثیر این موجودات و جدا سازی مواد دارویی از آنان، در قلمرو تجربه و آزمایش باقی مانده است. با این حال با توجه به روند رو به پیشرفت علم، داروهای دریایی دورنمایی بسیار درخشان داشته و در آینده نزدیک منجر به ایجاد و گسترش شیوه های درمانی کارا در عرصه پزشکی خواهند شد.
Natural products from plants, animals, microbes and minerals have long been a traditional source for treating human diseases. Recent advances in analytical, spectroscopic, and high-throughput screening technology have greatly revived the discovery of natural drugs, including the contribution of marine products-based drugs. The marine environment is a unique resource that contains enormous biological diversity and may potentially lead to successful treatments. An increasing number of compounds from marine sources are entering clinical trials, and thus, the field's impact on the pharmaceutical industry is increasing. Marine organisms are excellent producers of natural chemicals with diverse structures and pharmacological activities. Most of the new products being produced from the sea are anti-tumor, anti-inflammatory and anti-infectious products. Invertebrates and seaweeds are diverse and at the same time rich sources of biologically active substances for the production of new drugs. Despite all the efforts made to isolate new drugs from the sea, due to the obstacles in the way of the mass production of these drugs, including the limitation of the reserves of marine organisms, the cultivation and propagation of these organisms and the isolation of medicinal substances from them, in the realm of experience and The test remains. However, according to the progress of science, marine medicines have a very bright perspective and will lead to the creation and expansion of effective treatment methods in the medical field in the near future.
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