Prevalence of addiction to tramadol and methadone and its complications in women - a review study
Subject Areas : Journal of Quality and Durability of Agricultural Products and Food StuffsKhadijeh saravani 1 , Bahman Fouladi 2 , Leli Rezaie Kahkhaie 3 , Mohaddith Del Pisheh 4
1 - Assistant Professor of Forensic Medicine, Department of Community Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
2 - Assistant Professor of Mycology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
3 - Assistant Professor of Infectious Disease, Department of Internal Medicine, School of Medicine, Amir al Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran
4 - Midwifery Expert, Student Research Committee, Faculty of Nursing and Midwifery, Zabol University of Medical Sciences, Zabol, Iran
Keywords: Addiction, Prevalence, methadone, drug side effects, Tramadol,
Abstract :
Introduction: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields today to reduce pain, on the other hand, excessive use of these drugs causes addiction and poisoning in users. Knowing the complications and symptoms of poisoning of these drugs, along with the prevalence of their consumption, can be used to take the necessary measures to limit arbitrary consumption and prevent poisoning in consumers, especially in women who form the foundation of society and family. It can be helpful.Materials and methods: This article is a systematic review to investigate the prevalence of tramadol and methadone use and the side effects of long-term use in women. In this research, the search was conducted in SID, MagIran, Pubmed, Medline and Google Scholar electronic databases and due to the large volume of study articles, it was limited to the years 2000 to 2022.Results and conclusions: By summarizing the findings of the studies, tramadol and methadone drugs are used by a wide range of people with different demographic conditions. The statistics of addiction in young people and the complications caused by women's addiction are far more than other groups. Considering the current conditions, it is necessary to be aware of the potential dangers of these two drugs and monitor their distribution and administration.
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1-Saravani KH, Badakhsh M, Shahraki I. A review of the side effects of tramadol over-dose. Scientific Journal of Forensic Medic-ine. 1399; 27(1): 15-20.
2-Yaraghi A, Talaei Zavareh A, Mansoor-ian M, Izadi Mod N. Evaluation of the effect of naltrexone on unintentional methadone poisoning. Journal of Isfahan Medical Sch-ool. 1395; 34(384): 580-588.
3-Akbarizadeh MR, Naderifar M, Abdoll-ahimohammad A, Saravani K. The causes of poisoning in children under 14 years old referred to Amir al-Momenin Ali hospital, Zabol, Iran. Medical Science. 2019; 23(98): 488-491.
4-Huh B, Park CH. Retrospective analysis of low-dose methadone and QTc prolong-ation in chronic pain patients. Korean J Anesthesiol. 2010; 58:43-338.
5-Stringer J, Welsh C, Tommasello A. Met-hadone-associated Q-T interval prolonga-tion and torsades de pointes. Am J Health Syst Pharm. 2009; 66: 33-825.
6-Yingxian X, Smith Richard D, Caruso Frank S, Kellar Kenneth J. "Blockade of Rat α3β4 Nicotinic Receptor Function by Meth-adone, Its Metabolites, and Structural Ana-logs". The Journal of Pharmacology and Experimental Therapeutics. 2001; 299 (1): 71-366.
7-Jovanović-Cupić V, Martinović Z, Nesić N. Seizures associated with intoxication and abuse of tramadol. Marquardt KA, Alsop JA, Albertson TE. Tramadol exposures rep-orted to statewide poison control system. 2005; 39(6): 44-1039.
8-Shadnia S, Esmaily H, Sasanian G, Pajo-umand A, Hassanian-Moghaddam H, Abd-ollahi M. Pattern of acute poisoning in The-ran-Iran in 2003. Hum Exp Toxicol 2007; 26(9): 6-753.
9-Mood NE, Sabzghabaee AM, Safdari A, Yaraghi A. Clinical Signs, Hospitalization Duration and Outcome of Tramadol Intoxi-cation. Journal of Isfahan Medical School. 2011; 28(117).
10-Abbasi B, Hafezimoghadam P, Nejad NA, Sarvari M, Ramim T. Assessment of time interval between tramadol intake and seizure and second drug-induced attack. Th-eran University Medical Journal. 2015;73 (8):9-592.
11-Aghakhani N, Nikoonejad A. Epidemi-ology of tramadol poisoning in urmia. J Urmia Nurs Midwifry Fac. 2015;12(12): 7-1081.
12-Ataee Z, Dadpour B. Hypoxic-ischemic encephalopathy in a young man due to tra-madol overdose. Journal of Emergency Pra-ctice and Trauma. 2020;6(2):4-112.
13-Ghorbani E. An Overview of the Variab-les of Women's Tendency to Drug Abuse and its Consequences. SocialHealth & Add-iction. 2015; 2(7): 151-175.
14-Mazinzni R. Women and Addiction (Abstract of the 10th Annual Congress of the Iranian Psychiatric Association). Jour-nal of Psychiatry and Clinical Psychology of Iran (Thought and Behavior). 2010; 16(3): 342.
15-Ghamari F, Mohammadbeigi A, Moha-mmadsalehi N, Hashiani AA. Internet Add-iction and Modeling its Risk Factors in Me-dical Students, Iran: Indian Journal of Psy-chological Medicine. 2011; 33(2):158.
16-Larijani M, Mir Hosseini Z. Semantic analysis of the life course of women under methadone treatment (from onset to rele-ase). Social Studies and Research in Iran. 1397; 7(4):649-675.
17-Bankadaran SH, Akbari Rad M, Hassan Izadeh M, Akhundpour Manteghi M, Firoo-zi A. Prolongation of QTc interval in metha-done users and its relationship with hormo-nal changes. Journal of Mashhad University of Medical Sciences. 1396; 60(2):441-449.
18-Shakoori H, Zarasaz M, Farajipour S, Salehi A, Salari H, Mohammadkhani M. The effect of methadone treatment on QTc interval electrocardiogram of opioid addi-cts. Scientific Journal of Gorgan University of Medical Sciences. 1393; 16(3):45-48.
19-Aghili M, Moloudi M, Afshar H, Salehi M, Hassanzadeh A, Adibi P. Prevalence of gastrointestinal symptoms in patients refer-ed to methadone maintenance treatment clinics (MMT) in Isfahan. Journal of Isfah-an Medical School. 1392; 31(240):843-850.
20-Chugh SS, Socoteanu C, Reinier K, Waltz J, Jui J, Gunson K. A community-based evaluation of sudden death associated with therapeutic levels of methadone. Am J Med. 2008; 121(1):66-71.
doi: 10.1016/j.amjmed.2007.
21-Al-Gommer O, Sanju G. Sexual Dysfun-ctions in Male Opiate Users: A Compara-tive Study of Heroin, Methadone, and Bupr-enorphine, Addictive Disorders & Their Treatment. 2007 :6(3): 137-143.
22-Sarhill N, Davis MP, Walsh D, Nouneh C. Methadone-induced myoclonus in adva-nced cancer. Am J Hosp Palliat Care. 2001; 18(1):3-51.
23-Trajanovska AS, Vujovic V, Ignjatova L, Janicevic-Ivanovska D, Cibisev A. Sex-ual dysfunction as a side effect of hyperp-rolactinemia in methadone maintenance th-erapy. Med Arch. 2013;67(1):48-50.
24-Saxon AJ, Ling W, Hillhouse M, Tho-mas C, Hasson A, Doraimani G, Tasissa G, Lokhnygina Y, Leimberger J, Bruce R. Bu-prenorphine/Naloxone and methadone effe-cts on laboratory indices of liver health: a randomized trial. Drug and alcohol depend-ence. 2013; 128(1-2):71-76.
25-Jansson LM, Dipietro JA, Velez M, Elko A, Williams E, Milio L, O'Grady K, Jones HE. Fetal neurobehavioral effects of expo-sure to methadone or buprenorphine. Neur-otoxicology and teratology. 2011; 33(2): 240-243.
26-Webster LR. Methadone Side Effects: Constipation, Respiratory Depression, Sed-ation, Sleep-Disordered Breathing, and the Endocrine System. In: Cruciani, R., Kno-tkova, H. (eds) Handbook of Methadone Prescribing and Buprenorphine Therapy. Springer, New York, NY. 2013.
27-Stein MD, Herman DS, Bishop S, Las-sor JA, Weinstock M, Anthony J, Anderson BJ. Sleep disturbances among methadone maintained patients. J Subst Abuse Treat. 2004 Apr; 26(3): 80-175.
28-Kheradmand A, Amini Ranjbar Z, Zeyn-ali Z, Sabahy AR, Nakhaee N. Sleep Qua-lity and Sexual Function in Patients Under Methadone Maintenance Treatment. Intern-ational journal of high risk behaviors & ad-diction. 2015; 4(4).
29-Ghorbani A, Mohammadi Nikou A. Pre-dictive Factors of Drug Addiction among Women in Golestan Province. Commonity health. 2019; 6(2):217-226.
30-Borna H, Borna P. Tramadol Depriva-tion Syndrome in Infants (Case Report). Journal of the School of Medicine. 1391; 70(6):389-392.
31-Ahmadi H, Hosseini S, Rezaei M. Epid-emiology of tramadol poisoning in Imam Khomeini Hospital in Kermanshah (2008). Journal of Kermanshah University of Medi-cal Sciences. 2008; 15(1):72-77.
32-Shokrzadeh M, Haji Mohammadi A, Delaram A, Shayesteh Y. Characteristics of hospitalized patients due to tramadol pois-oning in Gorgan during 2008-2015. Journal of Mazandaran University of Medical Scie-nces. 1395; 26(146):185-190.
33-Izadi N, Sabzeqbaei A, Safdari A, Yar-aghi A. Clinical symptoms, duration of hos-pitalization and follow-up in tramadol pois-oning and association of follow-up with these agents. Journal of Isfahan Medical School. 1389; 28(117):1187-1193.
34-Fathi Y, Bashirian S, Barati M, Hazav-ehi S. Evaluation of tramadol abuse status and related factors in students of three hig-her education centers in Hamadan. Ibn Sina Journal of Clinical Medicine (Scientific Jo-urnal of Hamadan University of Medical Sciences and Health Services). 1391; 19(3): 23-29.
35-Tatari F, Afshari D, Abdoli N, Rezaei M, Rostami M. Frequency of seizures due to tramadol use in patients referred to Farabi Hospital in Kermanshah (Abstract of the 10th Annual Conference of the Iranian Sci-entific Association of Psychiatrists). Iranian Journal of Psychiatry and Clinical Psychol-ogy (Thought and Behavior), (16, 3, 62 in a row) (with abstracts of articles of the 10th Annual Conference of the Iranian Psychia-tric Scientific Association). 1389.
36-Besic N, Smrekar J, Strazisar B. Acute pain and side effects after tramadol in breast cancer patients: results of a prospective do-uble-blind randomized study. Scientific re-ports. 2020;10(1):66-187.
37-Singh SK, Agarwal MM, Batra YK, Ki-shore AV, Mandal AK. Effect of lumbar-epidural administration of tramadol on low-er urinary tract function. Neurourol Urodyn. 2008; 27(1): 65-70.
38-Beyaz SG, Sonbahar T, Bayar F, Erdem AF. Seizures associated with low-dose tra-madol for chronic pain treatment. Anesthe-sia, essays and researches. 2016; 10(2): 376-378.
39-Taugourdeau S, Chiche L, Rouby F, De-fault A, Boyer M, Castellan D, Lanfranchi MA, Bornet C, Jean R, Harlé JR, Durand JM, Jean-Pastor MJ. Hypoglycémies sévèr-es au tramadol: deux nouvelles observations d'un effet indésirable non référencé [Severe hypoglycemia induced by tramadol: two new cases of an unlisted side effect]. Rev Med Interne. 2011 Nov; 32(11): 5-703. Fre-nch.
40-Mugunthan N, Davoren P. Danger of hy-poglycemia due to acute tramadol poison-ing. Endocr Pract. 2012; 18(6): e2-151.
41-Bonakdaran S, Akbari Rad M, Hasanza-deh Deloie M, Akhoondpoor manteghi M, Firoozi A. QTc prolongation in methadone users and its relation with hormonal chan-ges. medical journal of mashhad university of medical sciences. 2017; 60(2): 441-449.
42-Brennan MJ. The effect of opioid ther-apy on endocrine function. The American journal of medicine. 2013; 126(3 Suppl 1): S8-12.
43-Ghowsi M, Yousofvand N. Impact of morphine dependency and detoxification by methadone on male's rat reproductive syst-em. Iranian journal of reproductive medic-ine. 2015; 13(5): 275-282.
44-Ragni G, De Lauretis L, Bestetti O, Sghedoni D, Gambaro V. Gonadal function in male heroin and methadone addicts. Inte-rnational journal of andrology. 1988; 11(2): 93-100.
45-Vermeulen A. Environment, human rep-roduction, menopause, and andropause. En-vironmental health perspectives. 1993; 101 (2): 91-100.
46-Kazemzadeh, Farzaneh, Malzami, Sah-ar, Afshar Ardalan, Mohammad, Tuzandeh Jani, Amir Hossein, Ashnaei, Amir Hoss-ein. The effect of tramadol on test-icular tissue and the hormones insulin and testosterone in healthy and streptozotocin-stored mice. Iranian Journal of Obstetrics, Gynecology and Infertility. 1398; 22(12): 54-61. [Persian]
47-Methadone|Methadone|Drugs Addiction treatment Faran Shimi Pharmaceutical Co-mpany. 2021.
48-Saravani K, Kamal Al-Dini M, Asgari M. Investigating the cause of death of peo-ple under the age of 18 referred to the The-ran autopsy room between 2013 and 2014: a short report. Medical School Journal. 2018; 77(7):458-462.
49-Ataee Z, Dadpour B. Hypoxic-ischemic encephalopathy in a young man due to tra-madol overdose. Journal of Emergency Pra-ctice and Trauma. 2020; 6(2): 4-112.
50-Aghakhani N, Nikoonejad A. Epidemi-ology of tramadol poisoning in urmia. J Urmia Nurs Midwifry Fac. 2015; 12(12): 7-1081.
51-Barzeghar A, Kamali M, Eizadpanah F. Tramadol: use and misuse. Tehran: Peghha-ne Andishe. 2008:11-31.
52-Ghadirzadeh M, Yarinasab F, Amini K, Nazari I, Salari A. Mortality Rates Due to Substance and Stimulants Abuse in Corpses Submitted to the Forensic Medicine Organi-zation of Kohgiluyeh and Boyer-Ahmad Pr-ovince during 2013-2018. Iranian Journal of Forensic Medicine. 2019; 25(3): 50-145.