Noushin Nankali Articles List

List of Articles Noushin Nankali

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1 - Investigation of the Effect of Strontium Ion Content on Thermal, Bioactivity, Antibacterial Properties and Behavior of MC3T3-E1 Osteoblast Cells in Silicate-Based Bioactive Glass
Noushin Nankali Amirhossein Moghanian Morteza Saghafi Yazdi
10.30495/apme.2021.1923822.2032

Bioactive glass (BG), is able to bind to body tissues, in this regard, it can be considered suitable material for applications such as bone tissue engineering. In this study, we first synthesized and studied the structural changes, biocompatibility, in vitro bioactivity More

Bioactive glass (BG), is able to bind to body tissues, in this regard, it can be considered suitable material for applications such as bone tissue engineering. In this study, we first synthesized and studied the structural changes, biocompatibility, in vitro bioactivity, biological behavior and antibacterial properties of silicate-based BG containing with strontium. To evaluate the bioactivity, the BG powder was placed in a simulated body fluid (SBF) solution for 1, 3, 7 and 14 days and then before and after the mentioned time periods, the changes and the process of forming a hydroxyapatite (HA) layer on their surface was studied by using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), release rates of various ions elements, pH changes and scanning electron microscopy (SEM). The results of X-ray diffraction tests and infrared spectroscopy studies confirmed the formation of crystalline HA layer on the BG surface. Moreover, the results of live/dead assay, nucleus microstructure and actin microfilaments of MC3T3-E1 osteoblast cells showed that 5% of strontium in silicate-based bioactive glass led to the growth, proliferation and activity of MC3T3-E1 osteoblast cells. The results of cytotoxicity test and evaluation of alkaline phosphate activity showed that substitution of strontium instead of calcium in silicate-based bioactive glass composition not only did not cause cytotoxicity but also caused significant proliferation and activity of MC3T3-E1 osteoblast cells. Meanwhile, improvements in the antibacterial properties of strontium-containing bioactive glass against MRSA bacteria were observed in comparison with strontium-free bioactive glass. Manuscript profile
Open Access Article
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2 - Characterization and investigation of biocompatibility of bioactive glass 60 mol%SiO2-36 mol%CaO-4 mol%P2O5-5 mol%SrO containing zinc
Amirhossein Moghanian Noushin Nankali Morteza Saghafiyazdi

In this research, bioactive glasses 60mol%SiO2-36mol%CaO-4mol%P2O5-5mol%SrO containing 0, 5, and 8 mol% zinc were synthesized by sol-gel method, and the effect of adding ZnO microstructure, in vitro bioactivity and biocompatibility was investigated. To investigate the i More

In this research, bioactive glasses 60mol%SiO2-36mol%CaO-4mol%P2O5-5mol%SrO containing 0, 5, and 8 mol% zinc were synthesized by sol-gel method, and the effect of adding ZnO microstructure, in vitro bioactivity and biocompatibility was investigated. To investigate the in vitro bioactivity, glass powders were placed in the simulated body solution (SBF) for 14 days, and before and after the mentioned periods, the changes and process of hydroxyapatite (HA) phase formation on BGs surfaces, using characterization methods. Fourier transform infrared (FTIR), checking the release rate of different ions by inductively coupled plasma spectroscopy (ICP_AES), pH changes, and microstructure studies using a scanning electron microscope (SEM) were investigated. In the infrared Fourier transform spectroscopic analysis of the surface of the synthesized bioactive glasses after immersion in SBF solution, phosphate and carbonate bands were detected, indicating the synthesized glasses' bioactivity. Also, the scanning electron microscope images showed that the microstructure of HA created was spherical. Finally, among all the bioactive glasses synthesized in this research, S5Z5 bioactive glass was introduced as a new multi-functional biological bio-material in bone tissue engineering due to its osteogenic, biocompatibility, and bioactivity in vitro properties. Manuscript profile

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