Gamma-factor progesterone proliferation activating receptors are a ligand-activated transcription factor playing an important role in lipid metabolism. The present study was aimed at evaluating the effect of eight weeks of aerobic-resistance training on the expression o More
Gamma-factor progesterone proliferation activating receptors are a ligand-activated transcription factor playing an important role in lipid metabolism. The present study was aimed at evaluating the effect of eight weeks of aerobic-resistance training on the expression of gamma progesterone proliferator-activating receptor gene in patients with coronary artery bypass grafting. The research method was quasi-experimental and pre-test-post-test. The statistical population included all patients with coronary artery bypass grafting in Mashhad (Iran). Height 1.58 ± 0.03 (m), weight 68.11 ± 5.54 (kg), body mass index (BMI) 27.18 ± 2.47 (2 kg / m2) and disease history 75 8.75 ± 25/20 (month) were formed after coronary artery bypass surgery. According to the inclusion criteria, they were divided into experimental (14) and control (12) groups. Data were analyzed using independent t-test and paired t-test at the significance level of P≥0.05 and SPSS software version 21. The results showed that eight weeks of aerobic-resistance training increased the expression of PPARɣ gene in the combined training group compared to the control group (P = 0.001). Moreover, the results of the correlation test showed that the increase in PPAR gene expression in the combined training group had a significant increase in the post-test compared to the pre-test (P = 0.001), not significant in the control group (p = 0.081). The data of the present study showed that aerobic- resistance training with increasing PPARɣ gene expression could be effective in fat metabolism and related processes in patients with coronary artery bypass grafting.
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Cardiovascular diseases are the leading causes of mortality and death in all areas of the world except Africa. This study aimed at the effect of eight-week combined training on Endostatin and VEGF gene expression in CABG patients.This is an applied and semi-experimental More
Cardiovascular diseases are the leading causes of mortality and death in all areas of the world except Africa. This study aimed at the effect of eight-week combined training on Endostatin and VEGF gene expression in CABG patients.This is an applied and semi-experimental research with two groups (interventional and control), which was conducted as a pretest and posttest. 30 middle-aged CABG men were selected using purposive sampling based on inclusion criteria. Participants were randomly divided into two groups of control and combined training. Quantitative Real-time PCR was utilized to measure Endostatin and VEGF gene expression levels. The eight-week combined exercise training was conducted in three sessions per a week. Dependent t-test and independent t-test were used to data analysis. A significant increase was observed after eight weeks of combined training on VEGF gene expression in CABG patients. (p=0.001), but it was not Significant on Endostatin gene expression( p=0.38) . Eight weeks of combined Cardiac Rehabilitation training as the protocol used in this research increased the expression of the VEGF gene in CABG patients , but there were not any significant changes on Endostatin gene expression by this way. As a result, the increase in the VEGF gene is one of the results of adaptation to the combined exercise activity used in this study, and it appears that physical activity is an important and effective factor in the process of angiogenesis, and can play a key role in the prevention of cardiovascular diseases.
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