Effect of eight weeks aerobic training on the levels of antioxidant enzymes in the heart tissue of type 2 diabetic rats

Subject Areas :

آسیه عباسی دلویی ¹ , sahar rezaee ² , alireza barari ³ , mozghan ahmadi ⁴

1 - استادیار فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران
2 - Department of sport physiology, Ayatollah amoli branch, Islamic Azad University, amol, Iran
3 - Department of sport physiology, Ayatollah amoli branch, Islamic Azad University, amol, Iran.
4 - Department of Physical Education and Sport Science Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran.

Received: 2020-08-08 Accepted : 2020-09-20 Published : 2020-09-22

Keywords: Antioxidant enzymes, Rats, Diabetes, Aerobic training, Heart tissue,

Abstract :

Introduction & Objective: Chronic hyperglycemia is associated with enhanced oxidative stress-induced myocardial injury. The aim of this study was to investigate the of eight weeks aerobic training on the levels of antioxidant enzymes in the heart tissue of type 2 diabetic rats. Materials and Methods: To implementation of this experimental research, 40 male Wistar rats (weight 185.2±22.7 gr) randomly were divided into 4 groups including control, diabetes, training and diabetes-training. In this study, the rats were type 2 diabetic using peritoneal injection nicotinamide-STZ. aerobic training performed with intensity of 50-60% VO2max, 5 days a week and for 8 weeks. The levels of the antioxidant catalase, superoxide dismutase and glutathione peroxidase in heart tissue were measured using kit and by ELISA method. Data were analyzed by One-way ANOVA and Tukey post hoc test at the p < 0.05. Results: The results showed that the levels of antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the heart tissue of type 2 diabetic control rats was lower than the healthy control group (P=0.001). Eight weeks of aerobic training significantly increased the levels of antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the heart tissue of type 2 diabetic rats (P=0.001). Conclusion: According to the research results, aerobic exercise may improve the cardiac function of diabetic subjects by increasing the antioxidant enzymes in the heart tissue. As a result, these training are recommended as adjunctive therapy in these patients.

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