Protective Effect of Coenzyme Q10 and Vitamin C on Cysteamine�Induced Lipid Peroxidation

Subject Areas : clinical veterinary science

سروش Almasi ¹ ( Faculty of Veterinary Medicine‚ Karaj Branch‚ Islamic Azad University‚ Karaj‚ Iran )
بابک Rezvanjoo ² ( Department of basic Science‚ Faculty of Veterinary Medicine‚ Karaj Branch‚ Islamic Azad University‚ Karaj‚ Iran )
S.H Shirazibeheshtiha ³ ( Department of Clinical Sciences‚ Faculty of Veterinary Medicine‚ Karaj Branch‚ Islamic Azad University‚ Karaj‚ Iran )
علی Namvaran AbbasAbad ⁴ ( Young Researchers And Elite Club‚Tabriz Branch‚ Islamic Azad University‚Tabriz‚ Iran )
مهدی khosravi ⁵ ( Faculty of veterinary Medicine‚ Karaj Branch‚ Islamic Azad University‚ Karaj‚ Iran )

Received: 2016-11-04 Accepted : 2016-11-04 Published : 2014-03-21

Keywords: Coenzyme Q10, Oxidative stress, vitamin C, superoxide dismutase, Cysteamine, Glutathione peroxidase,

Abstract :

Benefts of antioxidant supplementation in various disorders through reducing free radicals and improving organsperformance have been reported. The aim of this study was to investigate the effects of coenzyme Q10 and vitaminC on Cysteamine-induced lipid peroxidation and oxidative stress.This experimental interventional study was conducted on male Wistar rats. Animals were divided into four groups(six rats) randomly. Groups were treated as; group 1 (Normal saline), Group 2 (Cysteamine), Group 3 (vitaminC plus Cysteamine), Group 4 (coenzyme Q10 plus Cysteamine). 24 hours after the last injection, rats wereanesthetized and sampled for investigations. Welch’s and Kruskal-Wallis tests were used for analyzing data and P< 0.05 was set the signifcance level.The results of this study indicate that injection of cysteamine signifcantly (P < 0.05) decreased glutathioneperoxidase activity compared with control group. Pretreatment with vitamin C signifcantly (P < 0.05) increasedglutathione peroxidase activity compared with cysteamine group. Pretreatment with coenzyme Q10 increasedglutathione peroxidase activity (P <0.001) and superoxide dismutase (P <0.05) signifcantly compared withcysteamine group.Based on the results of this study, coenzyme Q10 and vitamin C can be used in reducing oxidative stress inducedcysteamine.