terpenes

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1 - Anti-plasmodial diterpenes from the roots of Hypoestes forsskaolii (Vahl) R.Br (Acanthaceae)
Fred Wanyonyi Sawenja Ruth Anyango Omole Peter Gakio Kirira Hamisi Masanja Malebo Alex Kingóri Machocho Richard Maveke Musau Isalah Omolo Ndiege

Ethno-pharmacological surveys previously revealed that Hypoestes forskalei (Vahl) Sol. Roemer & Schl.(Acanthaceae), a local medicinal plant, is one of the most widely used herbs in traditional malaria therapy by the Marakwet and Kisii communities in Kenya. This stud أکثر

Ethno-pharmacological surveys previously revealed that Hypoestes forskalei (Vahl) Sol. Roemer & Schl.(Acanthaceae), a local medicinal plant, is one of the most widely used herbs in traditional malaria therapy by the Marakwet and Kisii communities in Kenya. This study was aimed at validating the indigenous medicinal knowledge claims on the efficacy of H. forskalei and its safety as a traditional anti-malarial drug. It involved the sequential solvent extraction of plant material, bioassay-guided separation and isolation of components, identification of anti-plasmodial principles of H. forskalei and determination of their cytotoxicity and selectivity. From the roots of H. forskalei, (3, 4a, 7, 7,10a-pentamethyl-1, 3-vinyl-dodecahydro-benzo[f]chromene (1) and (3,4a,7,7,10a-pentamethyl-3-vinyl-dodecahydrobenzo[f]chromen-8-ol (2) with moderate and mild anti-plasmodial activity at IC50 2.39±0.0 µg/mL (7.81 µM) and 4.34±0.03 µg/mL or 15.0 µM), respectively, were isolated plus the inactive kaur-16-en-19-oic acid (IC50 19.75±0.11 µg/mL or 65.40 µM) against Plasmodium falciparum D6 (CQ-sensitive) strain. تفاصيل المقالة

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2 - Phytochemicals in leaves and extracts of the variety “Plovdiv 7” of Bulgarian oriental tobacco (Nicotiana tabacum L.)
Venelina Popova Tanya Ivanova Albena Stoyanova Vasil Georgiev Tsveta Hristeva Violeta Nikolova Margarita Docheva Nikolay Nikolov Stanka Damianova

This study aims to identify and analyze the non-volatile fraction (chemicals, polyphenols, phenolic acids, flavonoids, and triterpenes) and volatile fraction (essential oil and crude extracted aroma fractions) present in the leaves of “Plovdiv 7” oriental to أکثر

This study aims to identify and analyze the non-volatile fraction (chemicals, polyphenols, phenolic acids, flavonoids, and triterpenes) and volatile fraction (essential oil and crude extracted aroma fractions) present in the leaves of “Plovdiv 7” oriental tobacco variety (N. tabacum L.). The results show that the nicotine content in leaves reaches 2.3% (DW) and chemicals such as betulin (2340.7 g/g), carnosic acid (845.2 µg/g) and ursolic acid (596.0 µg/g) (595.95 g/g ), are also present. In terms of free phenolic acids, chlorogenic acid (2545.0 g/g), ferulic acid (1561.8 g/g), and vanillic acid (4461.9 g/g) are found to be dominant. The flavonoid profile is dominated by myricetin (134.2 g/g), quercetin (334.1 g/g), apigenin (493.0 g/g) and luteolin (445.6 g/g). In the volatile fraction, nineteen volatile components were identified (92.3%) where (E)-phytol (53.4%) was the major compound followed by solanone (6.8%), cis-5-butyl-4-methyldihydrofuran-2(3H)-one (6.4%) and dihydro-β-ionone (5.2%). In addition, the antimicrobial activity of “Plovdiv 7” tobacco leaf aroma extracts (concrete and resinoid extract) are tested against nine microbial strains. The results show a weak antimicrobial activity against Staphylococcus aureus and Bacillus subtilis bacteria, whereas no activity is recorded for the other seven microbial strains tested. تفاصيل المقالة

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3 - Antimicrobial efficacy and chemical constituents of pseudo-stem essential oils from Zingiber castaneum
Le Thi Huong Trinh Thi Huong Nguyen Thi Bich Nguyen Thi Viet Abdulatif Olufemi Giwa-Ajeniya Isiaka Ogunwande

In this paper, chemical constituents and antimicrobial activity of essential oil from the pseudo-stem of Zingiber castaneum &Scaron;korničk. & Q.B. (Zingiberaceae) Nguyễn growing in Vietnam havw been reported. Essential oils were obtained by hydrodistillation using أکثر

In this paper, chemical constituents and antimicrobial activity of essential oil from the pseudo-stem of Zingiber castaneum &Scaron;korničk. & Q.B. (Zingiberaceae) Nguyễn growing in Vietnam havw been reported. Essential oils were obtained by hydrodistillation using the Clevenger-type apparatus. Chemical components of the essential oil were analyzed by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC/MS). The minimum inhibitory concentrations (MIC) were evaluated by the method of microdilution broth susceptibility assay. The main constituents of the oil were bicyclo germacrene (28, 15.8%), cis-β-elemene (18, 9.8%) and germacrene D (26, 9.2%). The pseudo-stem oil of Z. castaneum displayed antimicrobial activity against Pseudomonas aeruginosa (ATCC 25923), Aspergillus niger (ATCC 9763) and Fusarium oxysporum (ATCC 48112) with MIC values of 12.5 ± 0.57 μg/mL, 50 ± 1.00 μg/mL and 50 ± 0.50 μg/mL, respectively. The results indicate the potential of Z. castaneum essential oil as a source of antimicrobial agent. تفاصيل المقالة

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4 - In vivo anti-inflammatory and anti-nociceptive activities, and chemical constituents of essential oil from the leaf of Gardenia jasminoides J. Ellis (Rubiaceae)
Nudewhenu Opeyemi Avoseh Oladipupo Adejumobi Lawal Isiaka Ajani Ogunwande Roberta Ascrizzi Guido Flamini Elizabeth Amoo

The chemical constituents, anti-inflammatory and anti-nociceptive activities of the leaf essential oil hydrodisitlled from the Gardenia jasminoides J. Ellis (Rubiaceae) were reported. The chemical constituents of the essential were analyzed using gas chromatography-flam أکثر

The chemical constituents, anti-inflammatory and anti-nociceptive activities of the leaf essential oil hydrodisitlled from the Gardenia jasminoides J. Ellis (Rubiaceae) were reported. The chemical constituents of the essential were analyzed using gas chromatography-flame ionization detector (GC-FID) and gas chromatography coupled with mass spectrometry (GC/MS). The hot plate and carrageenan-induced models were used to determine the anti-nociceptive and anti-inflammatory activities. The main compounds of the oil were pentadecanal 17 (49.2%), geranial 4 (12.3%), ar-turmerone 14 (8.2%) and 10-epi-γ-eudesmol 10 (6.2%). The essential oil of G. jasminoides at 100 and 400 mg.kg-1 doses significantly (p < 0.001) increased the latency period for the reaction duration in the anti-nociceptive study. The carrageenan-induced edema model reveals the suppression of inflammatory mediators (p < 0.001) within 1st, 2nd and 4th h for 100 mg.kg-1 dose, 1st and 4th h (200 mg.kg-1) and 1st-3rd h (400 mg.kg-1). The results indicate the potential of G. jasminoides essential oil as a source of pain relieving agent. تفاصيل المقالة

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5 - A systematic review on the ethnobotany, essential oils, bioactive compounds, and biological activities of Tanacetum species
Majid Mohammadhosseini Magdalena Jeszka-Skowron

10.30495/tpr.2023.700612

This review paper was designed in order to compile the chemical profiles of the essential oils (EOs) of a wide spectrum of Tanacetum species as well as to unify the data available in the literature concerning different aspects of this genus in ethnobotany of different c أکثر

This review paper was designed in order to compile the chemical profiles of the essential oils (EOs) of a wide spectrum of Tanacetum species as well as to unify the data available in the literature concerning different aspects of this genus in ethnobotany of different countries worldwide. Biological activities and other bioactive compounds were presented, as well. In this regard, the literature and reliable scientific databases involving Scopus, Pubmed as well as all of the famous publishers involving Elsevier, Springer, Taylor and Francis, etc were systematically reviewed. As shown in this review, a variety of promising ethnobotanical and biological activities and properties have been reported for different species of this genus so far. In addition, a number of valuable bioactive compounds have been separated and characterizedin different Tanacetum species تفاصيل المقالة

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6 - A review of 13C NMR spectra of drimane sesquiterpenes
Sylvia Awino Opiyo

Drimane sesquiterpenes are important group of phytochemicals with a wide range of medicinal properties including antibacterial, antifungal, anti-inflammatory, antioxidant, antiplasmodial, antileishmanial, molluscicidal, antifeedant and insecticidal features. Due to thei أکثر

Drimane sesquiterpenes are important group of phytochemicals with a wide range of medicinal properties including antibacterial, antifungal, anti-inflammatory, antioxidant, antiplasmodial, antileishmanial, molluscicidal, antifeedant and insecticidal features. Due to their wide range of medicinal activities, scientists are prompted to continuously search for novel drimane sesquiterpenes since most of the currently available anti-infective agents have drawbacks such as drug resistance and side effects. Structure determination of new compounds relies on accurate interpretation of spectroscopic data which is quite challenging but can be simplified by comparison with the data of known related compounds from the reliable databases. A large number of drimane sesquiterpenes have been examined by 13C NMR spectroscopy but such data are scattered in the literature making it hard for researchers to use them. This paper provides a review on previously reported drimane sesquiterpenes and a compilation of their 13C NMR data. It also provides a brief discussion on the substituent effect on the 13C shielding of the drimane sesquiterpenes. تفاصيل المقالة

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7 - The rhizome essential oil of Curcuma aeruginosa Roxb. (Zingiberaceae) from Vietnam
Pham T. Oanh Nguyen T. Thanh Do T. Xuyen Le T. Huong Opeyemi N. Avoseh Isiaka A. Ogunwande

The volatile compounds identified from the rhizome oil of Curcuma aeruginosa Roxb (Zingiberaceae) collected from Cham Chu Natural Reserve, Tuyen Quang Province, Vietnam, are reported. The plant sample was air-dried for two weeks under laboratory shade. Essential oils we أکثر

The volatile compounds identified from the rhizome oil of Curcuma aeruginosa Roxb (Zingiberaceae) collected from Cham Chu Natural Reserve, Tuyen Quang Province, Vietnam, are reported. The plant sample was air-dried for two weeks under laboratory shade. Essential oils were obtained by hydrodisitllation in a Clevenger-type apparatus. The yield of the oil was 0.18% (v/w) regarding the dry weight of the plant material. The constituents of the oil were analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS). The main constituents of the oil were found to be β-pinene (21.9%), neocurdione (16.1%) and curcumol (15.2%). تفاصيل المقالة

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8 - Evaluation of triterpenes isolated from stems of Pouteria macahensis T. D. Penn. against Proteus mirabilis
Gabriel da Silva Amaral Hermerson Dantas dos Santos Aline Oliveira da Conceição Fernando Faustino de Oliveira Rosilene Aparecida de Oliveira

This article presents the results from a phytochemical study on an acetonic extract from the stems of Pouteria macahensis T.D. Penn., an endemic species of the Brazilian Atlantic Rainforest. By means of the bioautography method, this extract was evaluated against Acinet أکثر

This article presents the results from a phytochemical study on an acetonic extract from the stems of Pouteria macahensis T.D. Penn., an endemic species of the Brazilian Atlantic Rainforest. By means of the bioautography method, this extract was evaluated against Acinetobacter baummanii, Proteus mirabilis, Escherichia coli and Staphylococcus epidermidis bacteria, of which only the P. mirabilis was found to be susceptible. The acetonic extract was chromatographed on a silica gel column, eluted with hexane and ethanol, producing 14 groups, allowing the isolation of the following compounds: friedelin, 3β-friedelinol and 3β-erythrodiol linoleate, arachidate and linolenate. Their structures were elucidated based on data of IR, 1H NMR, 13C NMR, including DEPT-135, HSQC and HMBC techniques. The minimum inhibitory concentrations of the compounds tested against P. mirabilis growth, were 500.0 μg mL-1 for friedelin and erythrodiol and 600.0 μg mL-1 for 3β-friedelinol and esterified 3β-erythrodiol. Based on these results, the potential of these compounds to inhibit the growth of this bacterium was confirmed. تفاصيل المقالة

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9 - آنالیز اجزای اسانس مریم گلی (Salvia nemorosa L.) مناطق اهر و ارومیه در مراحل رشد رویشی و گل دهی به روش GC/MS
الهام قافیه‌سنج کمال الدین دیلمقانی نادر چاپارزاده سارا سعادتمند

10.30495/iper.2022.1943401.1740

هدف از تحقیق حاضر بررسی اجزای اسانس گیاهان مریم گلی جنگلی (Salvia nemorosa L.) دو منطقه اهر و ارومیه در دو مرحله فنولوژیکی، رویشی و گل‌دهی، بود. بخش‌های هوایی گیاهان در این دو مرحله جمع‌آوری و خشکانده شده و اسانس‌گیری به روش تقطیر با آب توسط کلونجر انجام شد. اسانس‌ها با أکثر

هدف از تحقیق حاضر بررسی اجزای اسانس گیاهان مریم گلی جنگلی (Salvia nemorosa L.) دو منطقه اهر و ارومیه در دو مرحله فنولوژیکی، رویشی و گل‌دهی، بود. بخش‌های هوایی گیاهان در این دو مرحله جمع‌آوری و خشکانده شده و اسانس‌گیری به روش تقطیر با آب توسط کلونجر انجام شد. اسانس‌ها با استفاده از دستگاه‌های GC و GC/MS و با محاسبه شاخص بازداری کواتس تجزیه و شناسایی شدند. نتایج نشان دادند که درصد اسانس سرشاخه‌های گل‌دار در هر دو منطقه اهر و ارومیه در مقایسه با برگ‌های مرحله رویشی بالاتر بود. بیش‌ترین درصد و اجزای اسانس در سرشاخه‌های گل‌دار و در برگ مرحله رویشی در گیاهان منطقه اهر و کم‌ترین میزان درصد اسانس در سرشاخه‌های گل‌دار و در برگ مرحله رویشی در گیاهان منطقه ارومیه مشاهده شد. کریوفیلن اکساید در اسانس سرشاخه‌های گل‌دار و در برگ مرحله رویشی گیاهان هر دو منطقه ترکیب اصلی بود. درصد کریوفیلن اکساید در اسانس سرشاخه‌های گل‌دار گیاهان ارومیه (41/26 درصد) نسبت به اسانس برگ مرحله رویشی (19/18 درصد) بیش‌تر و برعکس، درصد این ماده در برگ مرحله رویشی گیاهان اهر (37/28 درصد) در مقایسه با سرشاخه‌های گل‌دار این گیاهان (79/12درصد) بالاتر بود. علاوه بر کریوفیلن اکساید، ترکیباتی مانند اسپاتولنول، ترانس- ‌بتا-کریوفیلن، پاراسیمن، 1-اکتن3-ال و ترپینن-4-ال با درصدهای متفاوت در اسانس سرشاخه گل‌دار در گیاهان هر دو منطقه و ترانس–بتا کریوفیلن، بتا-ایونن و کامفور در اسانس برگ مرحله رویشی گیاهان اهر وجود داشتند. سزکوئی‌ترپن‌های اکسیژن‌دار در اسانس سرشاخه گل‌دار و برگ مرحله رویشی در گیاهان هر دو منطقه در مقایسه با سایر گروه‌های شیمیایی اسانس بالاترین مقدار را نشان دادند. مقدار سزکوئی‌ترپن‌های اکسیژن‌دار در اسانس سرشاخه‌های گل‌دار گیاهان جمع‌آوری شده از منطقه ارومیه (31/46%) و اسانس برگ مرحله رویشی گیاهان اهر (3/34%) بود. تفاصيل المقالة

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10 - Enhancement of valerenic acid production in Valeriana officinalis roots by methyl jasmonate -mediated transcriptional changes of sesquiterpene synthase genes
Hengameh Taheri Mansour Ghesmati

10.30495/ijpp.2018.545660

Valeriana officinalis (valerian), as a nutraceutical herb, is widely used for its sedative and hypnotic properties. It is known that C15 sesquiterpenoid valerenic acid (VA) is the active ingredient responsible for pharmacological effects of V. officinalis. To evaluate t أکثر

Valeriana officinalis (valerian), as a nutraceutical herb, is widely used for its sedative and hypnotic properties. It is known that C15 sesquiterpenoid valerenic acid (VA) is the active ingredient responsible for pharmacological effects of V. officinalis. To evaluate the effect of methyl jasmonate (MeJA) concentrations (50 and 100 µM) in the modulation of expression patterns of the genes involved in valerenic acid (VA) biosynthesis, transcript abundance of identified sesquiterpene synthase (Sesqui-TPS) genes in the root of V. officinalis was monitored by quantitative real time PCR (qRT-PCR) within a 144 h time period. In addition, Valerenic acid contents were measured by high-performance liquid chromatography (HPLC). The highest amount of VA (12.45 mg/g dry weight (DW)) was found at 100 µM MeJA with a 12 fold increase over control culture (1.03 mg/g DW) at exposure time of 72 h. Moreover, MeJA in a concentration dependent manner enhanced transcription rate of VoTPS1 and VoTPS7 genes. Accordingly, exposure to 100 µM MeJA for 24 h can be more effective in the induction of these genes than that observed for 50 µM. Such enhancement was correlated with increased VA accumulation suggesting that these genes may be responsible for the biosynthesis of intermediates involved in the VA-biosynthetic pathway. However, MeJA treatment seemed to have a less significant effect on VoTPS3 expression than VoTPS1 and VoTPS7 genes. This results provide insights for more effective biosynthesis of VA by MeJA-mediated transcriptional changes of putative sesqui-TPS. تفاصيل المقالة

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11 - Enhancement of valerenic acid production in Valeriana officinalis roots by methyl jasmonate-mediated transcriptional changes of sesquiterpene synthase genes
Hengameh Taheri Mansour Ghesmati

10.30495/ijpp.2018.541007

Valeriana officinalis (valerian), as a nutraceutical herb, is widely used for its sedative and hypnotic properties. It is known that C15 sesquiterpenoid valerenic acid (VA) is active ingredient responsible for pharmacological effects of V. officinalis. To evaluate the e أکثر

Valeriana officinalis (valerian), as a nutraceutical herb, is widely used for its sedative and hypnotic properties. It is known that C15 sesquiterpenoid valerenic acid (VA) is active ingredient responsible for pharmacological effects of V. officinalis. To evaluate the effect of methyl jasmonate (MeJA) concentrations (50 and 100 µM) in the modulation of expression patterns of the genes involved in valerenic acid (VA) biosynthesis, transcript abundance of the identified sesquiterpene synthase (Sesqui-TPS) genes in the root of V. officinalis was monitored by quantitative real time PCR (qRT-PCR) within a 144 h time period. In addition, valerenic acid contents were measured by high-performance liquid chromatography (HPLC). The highest amount of VA (12.45 mg/g dry weight (DW)) was found at 100 µM MeJA with a 12-fold increase over control culture (1.03 mg/g DW) at exposure time of 72 h. Moreover, MeJA in a concentration dependent manner, enhanced transcription rate of VoTPS1 and VoTPS7 genes. Accordingly, exposure to 100 µM MeJA for 24 h can be more effective on induction of these genes than observed for 50 µM. Such enhancement correlated with increased VA accumulation suggesting that these genes may be responsible for the biosynthesis of intermediates involved in the VA-biosynthetic pathway. However, MeJA treatment seemed to have a less significant effect on VoTPS3 expression than VoTPS1 and VoTPS7 genes. These results provide insights for more effective biosynthesis of VA by MeJA-mediated transcriptional changes of putative sesqui-TPS. تفاصيل المقالة

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12 - اثر دما و زمان انبارداری بر ترکیبات معطر عرق نعناع سبز
امین پناهی فرشاد صادقی

10.22034/aej.2017.532505

مونوترپن ها ترکیبات عمده اسانس و عرق گیاهان دارویی می باشند که ممکن است تحت تأثیر نور، زمان و دمای انبار قرار گیرند. این پژوهش به منظور تعیین اثر دما و زمان نگهداری عرق نعناع سبز بر ترکیبات مونوترپن آن، به صورتفاکتوریل در قالب طرح کاملاً تصادفی در سه تکرار انجام پذیرفت. أکثر

مونوترپن ها ترکیبات عمده اسانس و عرق گیاهان دارویی می باشند که ممکن است تحت تأثیر نور، زمان و دمای انبار قرار گیرند. این پژوهش به منظور تعیین اثر دما و زمان نگهداری عرق نعناع سبز بر ترکیبات مونوترپن آن، به صورتفاکتوریل در قالب طرح کاملاً تصادفی در سه تکرار انجام پذیرفت. دمای نگهداری شامل 25+، 4+ و 18- درجه سلسیوس و زمان انبارداری 1، 2 و 3 ماه بود. اندام هوایی نعناع پس از خشک شدن در سایه با دستگاه کلونجر عرق گیری شد. حلال دی اتیل اتر، جهت خالص سازی اسانس از عرق نعناع استفاده و تعیین ترکیبات تشکیل دهنده اسانس با دستگاه طیف نگار گازی متصل به طیف سنج جرمی انجام شد. در مجموع 29 ترکیب شیمیایی در عرق تازه نعناع سبز تشخیص داده شد. از بین مونوترپن ها، کارون، منتول، 1و8- سینوئل، پولگون، ان-دکان و پیپرتونین شناسایی شدند. تنها کارون تحت زمان و دمای انبار قرار نگرفت. سایر ترکیبات تحت تأثیر فاکتورهای مورد بررسی قرار گرفته و به یکدیگر تبدیل شدند. منتول که جزء اصلی عرق نعناع از لحاظ طعم و خاصیت ضدمیکروبی به شمار می رود، در دمای اتاق و یخچال بالاتر از مقدار آن در نگهداری در شرایط فریزر بود. در نهایت توصیه می گردد نگهداری عرق نعناع در دمای اتاق انجام گردد. تفاصيل المقالة

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