biological activity

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1 - Electronic Structure, Biological Activity, Natural Bonding Orbital (NBO) and Non-Linear Optical Properties (NLO) of Poly-Functions Thiazolo [3,2-a]Pyridine Derivatives. DFT Approach
Shimaa Hussien hussien moustafa

The optimized structures of studied compounds 23-28 are non planner with the two phenyl at C3 and C9 are out of the molecular plane of thiazolo[3,2-a]pyridine as indicated from a dihedral angles of 710 and 1160 respectively, using DFT-B3LYP method with 6-311G(d,p) as ba أکثر

The optimized structures of studied compounds 23-28 are non planner with the two phenyl at C3 and C9 are out of the molecular plane of thiazolo[3,2-a]pyridine as indicated from a dihedral angles of 710 and 1160 respectively, using DFT-B3LYP method with 6-311G(d,p) as basis set. The natural bonding orbital (NBO) analysis of the parent molecule 23 have been analyzed in terms of the hybridization of each bond, natural charges, bonding and antibonding orbital's, and second order perturbation energy (E(2)). The calculated EHOMO and ELUMO energies of the studied compounds can be used to explain the extent of charge transfer in the molecule and to calculate the global properties; the chemical hardness (η), global softness (S), electrophilicity (ω), and electronegativity (χ). The effect of substituent's of different strengths on the geometry, energetic and nonlinear optical properties are analyzed and discussed. The NLO parameters: static dipole moment (µ), polarizability (α), anisotropy polarizability (Δα), and first order hyperpolarizability (βtot), of the studied compounds have been calculated at the same level of theory and compared with the proto type Para-Nitro-Aniline (PNA). The results of (βtot) promising electrical properties. The 3D plots of the molecular electrostatic potential (MEP) for some selected compounds were investigated and describing the electrophilic and nucleophilic sites. The biological activity of the studied compounds was tested against gram positive, gram negative and Fungi. A correlation between energetic, global properties and biological activity were investigated and discussed. تفاصيل المقالة

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2 - TD-DFT Calculations, Electronic Structure, Biological Activity, NBO, NLO Analysis and Electronic Absorption Spectra of Some 3-Formylchromone Derivatives
Shimaa Hussien hussien moustafa Nabil H. Amin Magdy A. Ibrahima ELShimaa Ibrahima

The electronic structure and spectra of 3-formylchromone and some of its derivatives are investigated using TD-DFT/B3LYB/6-311G (d, p) level of theory. The results of calculations show that all the studied compounds 16 are planar, as indicated from the dihedral angles. أکثر

The electronic structure and spectra of 3-formylchromone and some of its derivatives are investigated using TD-DFT/B3LYB/6-311G (d, p) level of theory. The results of calculations show that all the studied compounds 16 are planar, as indicated from the dihedral angles. The electronic absorption spectra of the studied compounds are recorded in the UV-Vis region, in both ethanol (as polar solvent) and dioxane (as non-polar solvent). The observed vertical electronic transitions assignments are facilitated via time-dependent density functional theory TD-DFT. The theoretical spectra computed at CAM-B3LYP/6-311G (d, p) in gas phase, ethanol and dioxane nicely reproduce the observed spectra. The natural bond orbital (NBO) analysis were discussed in terms of the extent of delocalization, intermolecular charge transfer and second order perturbation interactions between donor and acceptor MOs. The calculated EHOMO and ELUMO esame level of theory and compared with the proto type Para-Nitro-Aniline (PNA), show promising optical properties. 3D-plots of the molecular electrostatic potential (MEP) for some of the studied compounds are investigated and analyzed showing the distribution of electronic density of orbital's describing the electrophilic and nucleophilic sites of the selected molecules. The biological activity of the studied compounds was tested against gram positive, gram negative and Fungi. تفاصيل المقالة

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3 - Characterization of bioactive compounds from <i>Ficus vallis-choudae</i> Delile (Moraceae)
Jean Jules Kezetas Bankeu Amadou Dawé Marius Mbiantcha Guy Raymond Feuya Iftikhar Ali Marthe Aimée Tchuente Tchuenmogne Lateef Mehreen Bruno Lenta Muhammad Ali Augustin Silvère Ngouela

Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide n أکثر

Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity. تفاصيل المقالة

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4 - A review on pharmacological potentials of phenolic diterpenes carnosic acid and carnosol obtained from Rosmarinus officinalis L. and modern extraction methods implicated in their recovery
Dhananjay Singh Nishu Mittal Mohammed Siddiqui

10.30495/tpr.2023.1990761.1365

Rosmarinus officinalis L. is a perennial herb, known for culinary as well as medicinal properties. It has been shown that bioactive compounds like rosmarinic acid, carnosic acid, and carnosol are responsible for the medicinal properties of this plant species. Carnosic a أکثر

Rosmarinus officinalis L. is a perennial herb, known for culinary as well as medicinal properties. It has been shown that bioactive compounds like rosmarinic acid, carnosic acid, and carnosol are responsible for the medicinal properties of this plant species. Carnosic acid is a phenolic diterpene synthesized in young leaves of rosemary, whereas carnosol is produced after the oxidation of carnosic acid. Several studies have confirmed their antiangiogenic, anti-inflammatory, antimicrobial, antidiabetic, antioxidant, antitumor, neuroprotective, and gastroprotective properties. Ethanol, a mixture of ethanol-acetone, and hexane have been recommended as the best solvents for the extraction of carnosic acid, but advanced extraction techniques such as microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), etc. have been used to extract these phenolic antioxidant compounds in higher yield. This report is a kind of first study that emphasizes the recent research on the pharmacological potentials of carnosic acid and carnosol and summarizes the studies on modern extraction procedures. تفاصيل المقالة

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5 - Unleashing the power of garlic polyphenols: Insights into extraction, identification, structural characteristics and bioactivities
Monika Monika Sanjeev Gupta

Garlic has been well recognized as a nutrient-rich food and conventional remedy in history. One of the key effective components of garlic is its polyphenols, which exhibit various bioactivities, including anti-cancerous, immune enhancing, and antioxidant properties. Gar أکثر

Garlic has been well recognized as a nutrient-rich food and conventional remedy in history. One of the key effective components of garlic is its polyphenols, which exhibit various bioactivities, including anti-cancerous, immune enhancing, and antioxidant properties. Garlic polyphenols consist of flavonoids, such as quercetin, kaempferol, and apigenin, and phenolic acids, including caffeic acid, ferulic acid, and gallic acid. Given its significant marketing potential and development prospects, garlic polyphenols have garnered substantial interest from researchers worldwide. This review is directed to provide comprehensive and up-to-date information on the extraction, identification, structural characteristics, and bioactivities of garlic polyphenols. Further, it presented compelling evidence to use polyphenols as medicinal foods. تفاصيل المقالة

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6 - The genus <i>Micromeria</i> Benth.: An overview on ethnobotany, chemotaxonomy and phytochemistry
Majid Mohammadhosseini Alessandro Venditti Guido Flamini Satyajit Sarker Mohammadreza Kalaee

10.30495/tpr.2022.694114

The genus Micromeria Benth. from the family Lamiaceae mainly comprises herbaceous plants having several remarkable ethnobotanical, biological and phytochemical applications. This review critically appraises all the information available in the literature, e.g., Scopus, أکثر

The genus Micromeria Benth. from the family Lamiaceae mainly comprises herbaceous plants having several remarkable ethnobotanical, biological and phytochemical applications. This review critically appraises all the information available in the literature, e.g., Scopus, Institute for Scientific Information-Web of Science (ISI-WOS) as well as Medline on various species of this genus covering aspects of biological activity, ethnobotanical, chemical taxonomy and phytochemistry. The phytochemical composition of both essential oils and non-volatile extracts is reported. Their chemotaxonomic implications and ethnomedicinal impacts are also discussed. The pharmacological properties of crude extracts and isolated phytochemicals from Mircomeria spp. observed in several bioactivity tests are also critically reviewed. From phytochemical point of view, the characterization of the organic extracts of different Mircomeria spp. has led to the identification of some valuable natural compounds. Furthermore, the chemical profiles of most of the species are dominated by oxygenated monoterpenes. A wide spectrum of promising biological properties have been attributed to Mircomeria species including antibacterial, antifungal, antioxidant, anticholinesterase, tyrosinase inhibition and antinociceptive activities. Moreover, it has been shown that rosmarinic acid serves as a marker compound in several entities of this genus. تفاصيل المقالة

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7 - اثر بیولوژیکی indica Piriformospora، vermifera Sebacina و Trichoderma spp. علیه بیماری پژمردگی فوزاریومی عدسدر شرایط گلخانه‌ای
حسین کاری دولت آبادی ابراهیم محمدی گل تپه

بیماری پژمردگی فوزاریومی عدس که توسط Fusarium oxysporum f.sp. lentis (Vasd. & Srin.) Gordonایجاد می گرددیکی از عوامل مهم کاهش محصول این گیاه در دنیا به شمار می رود. تأثیر چهار قارچ خاکزی Piriformospora indica، Sebacina vermifera ، Trichoderma harzianum و Trichoderma أکثر

بیماری پژمردگی فوزاریومی عدس که توسط Fusarium oxysporum f.sp. lentis (Vasd. & Srin.) Gordonایجاد می گرددیکی از عوامل مهم کاهش محصول این گیاه در دنیا به شمار می رود. تأثیر چهار قارچ خاکزی Piriformospora indica، Sebacina vermifera ، Trichoderma harzianum و Trichoderma viride روی پژمردگی فوزاریومی عدس در طرح کاملا تصادفی در شرایط گلخانه ای مورد ارزیابی قرار گرفت. بیمارگر در 3 زمان مختلف نسبت به کاشت بذر عدس رقم محلی اردبیل (10 روز قبل، همزمان و 10 روز بعداز کاشت) به خاک گلدان ها اضافه گردید. 17 تیمار که شامل دو شاهد (گیاه بدون بیمارگر و گیاه با بیمارگر) و 15 ترکیب مختلف قارچ های آنتاگونیست فوق بود، همزمان با کاشت بذر به خاک گلدان ها اضافه گردید. ارزیابی شاخص های مختلف رشدی (ارتفاع گیاه، طول ریشه، وزن خشک اندام هوایی و ریشه) و شدت بیماری در مرحله گلدهی انجام گرفت. نتایج نشان داد که موثرترین ترکیب آنتاگونیست ها در اکثر فاکتورهای رشدی و در کاهش شدت بیماری با در نظر گرفتن سه زمان مختلف مایه زنی، تیمار (S. vermifera + T. harzianum) است. تفاصيل المقالة

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8 - کارایی عصاره بادیان رومی (Pimpinella anisum)روی فعالیت زیستی Tribolium castaneum و بررسی عملکرد آنتی اکسیدانی آن
شهلا امینی پریسا جنوبی عارف معروف احمد مجد

شپشه آرد Tribolium castaneumیکی ازآفات مهم محصولات انباری می&lrm;باشد، برای کنترل این آفات عصاره&lrm;های گیاهی جایگزین مناسبی برای سموم شیمیایی قلمداد می&lrm;شوند. از سوی دیگر گیاهان دارویی به عنوان منابع طبیعی که دارای خاصیت آنتی&lrm;اکسیدانی هستند، مورد توجه محققین بر أکثر

شپشه آرد Tribolium castaneumیکی ازآفات مهم محصولات انباری می&lrm;باشد، برای کنترل این آفات عصاره&lrm;های گیاهی جایگزین مناسبی برای سموم شیمیایی قلمداد می&lrm;شوند. از سوی دیگر گیاهان دارویی به عنوان منابع طبیعی که دارای خاصیت آنتی&lrm;اکسیدانی هستند، مورد توجه محققین برای استفاده در سامانه&lrm;های غذایی و بیولوژیک قرار گرفته&lrm;اند. این تحقیق به منظور بررسی کارایی عصاره بادیان رومی (Pimpinella anisum)روی فعالیت زیستی شپشه آرد و همچنین بررسی عملکرد آنتی&lrm;اکسیدانی این گیاه می&lrm;باشد. در این پژوهش اثر عصاره بذر بادیان رومی روی شاخص&lrm;های تغذیه&lrm;ای حشرات کامل شپشه آرد، درسه غلظت 50، 75 و 100 میکرولیتر و اثرات سمیت تنفسی عصاره نیز (با غلظت&lrm;های 50، 89، 158، 281 و 500 میکرولیتر بر لیتر هوا) در شرایط آزمایشگاهی (دمای 1±29 درجه سلسیوس و رطوبت نسبی 5±65 درصد) انجام شد. همچنین خواص آنتی&lrm;اکسیدانی بادیان رومی با استفاده از دو روش مهار رادیکال پایدار 2و2 دی فنیل-1- پیکریل هیدرازیل (DPPH) و قدرت احیاکنندگی آهن مورد بررسی قرار گرفت. بررسی شاخص‌های تغذیه&lrm;ای نشان داد که بالاترین و پایین ‌ترین غلظت عصاره به ترتیب 86/94 و 68/82 درصد، بازدارندگی تغذیه&lrm;ای داشت. همچنین بیشترین مقدار تلفات در غلظت 500 میکرولیتر بر لیتر هوا و در زمان 24 ساعت ثبت گردید. غلظت لازم برای مرگ و میر 50 درصد جمعیت (LC50) در زمان 24 ساعت پس از تیمار، 19/215 میکرولیتر بر لیتر هوا ثبت شد. در آزمون DPPH، عصاره برگی، غلظت مهار 50 درصد (IC50) بالاتری نسبت به بذر نشان داد، در آزمون احیاکنندگی آهن نیز نتیجه مشابهی بدست آمد. تفاصيل المقالة

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9 - بررسی روش های سنتز، مکانیسم و خواص بیولوژیک ترکیبات بتا-لاکتام تک حلقه ای
رقیه حیران

چکیده: هتروسیکل های مبتنی بر نیتروژن در شیمی دارویی جایگاه ویژه ای دارند و بیش از 75 درصد داروهای تایید شده توسط سازمان غذا و دارو هتروسیکل های نیتروژن دار می باشند. بتا-لاکتام ها ترکیبات حلقوی 4 عضوی حاوی نیتروژن بوده و به عنوان هسته آنتی بیوتیک پنی سیلین شناخته شده ان أکثر

چکیده: هتروسیکل های مبتنی بر نیتروژن در شیمی دارویی جایگاه ویژه ای دارند و بیش از 75 درصد داروهای تایید شده توسط سازمان غذا و دارو هتروسیکل های نیتروژن دار می باشند. بتا-لاکتام ها ترکیبات حلقوی 4 عضوی حاوی نیتروژن بوده و به عنوان هسته آنتی بیوتیک پنی سیلین شناخته شده اند. از زمان کشف ساختار پنی سیلین تاکنون چندین استراتژی برای سنتز این دسته از ترکیبات معرفی شده است. در این راستا، مطالعات گسترده ای نیز بر روی فضا گزینی تشکیل حلقه بتا-لاکتام صورت پذیرفته است. در سال های اخیر، به منظور دست یابی به ترکیباتی با فعالیت های بیولوژیکی خاص، محققان بسیاری به سنتز و اصلاح حلقه بتا-لاکتام پرداخته اند. این دسته از ترکیبات به جز فعالیت ضد باکتریایی، می توانند به عنوان ضد قارچ، ضد مالاریا، ضد التهاب، ضد سرطان و غیره عمل کنند. به علاوه به عنوان مهار کننده جذب کلسترول و مهار کننده سایر آنزیم ها نیز شناخته شده اند. به طور کلی اعتقاد بر این است که فعالیت این دسته از ترکیبات، به فعالیت شیمیایی حلقه بتا-لاکتام و استخلاف های واقع بر روی این حلقه مرتبط است. در این مقاله مروری، به معرفی بتا-لاکتام ها، انواع روش های سنتز و فعالیت بیولوژیک برخی مونو باکتام های سنتزی با تکیه بر فعالیت های انجام شده در ده سال اخیر، پرداخته شده است. تفاصيل المقالة

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10 - Synthesis, characterization and catalytic activity of plant-mediated MgO nanoparticles using Mucuna pruriens L. seed extract and their biological evaluation
Samira Rahmani-Nezhad Shima Dianat Mina Saeedi Abbas Hadjiakhoondi

10.22034/jna.2017.544640.1041

Development of green and efficient procedures for the synthesis of metallic nanoparticles has emerged as a significant topic in the field of nanotechnology. In this respect, using natural resources especially plant extract has attracted lots of attention; plant extract أکثر

Development of green and efficient procedures for the synthesis of metallic nanoparticles has emerged as a significant topic in the field of nanotechnology. In this respect, using natural resources especially plant extract has attracted lots of attention; plant extract is a promising alternative to traditional and chemical techniques. The plant Mucuna pruriens L. contains high concentration of L-dopa in the seeds; it has been used as a nerve tonic for nervous system disorders including Parkinson’s disease. In this work, a rapid and efficient synthesis of stable magnesium oxide nanoparticles (MgO NPs) using aqueous extract of Mucuna pruriens seeds were reported. The biologically synthesized MgO NPs were characterized by UV–Visible and Fourier transform infrared (FTIR) spectroscopy as well as X-ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM). The potential of MgO nanoparticles in the degeneration of methyl orange (MO) and methylene blue (MB) dyes were assessed in different conditions. The results of these investigations showed that the synthesized MgO NPs have a good catalytic activity in the removal of both dyes. Biological study of biosynthesized MgO NPs showed moderate antibacterial property against four strains of bacteria and a very good antioxidant activity. تفاصيل المقالة

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11 - Synthesis, Characterization and Catalytic Activity of Plant- Mediated MgO Nanoparticles Using Mucuna Pruriens L. Seed Extract and Their Biological Evaluation
Samira Rahmani-Nezhad Shima Dianat Mina Saeedi Abbas Hadjiakhoondi

10.22034/jna.2017.540020

Development of green and efficient procedures for the synthesis of metallic nanoparticleshas emerged as a significant topic in the field of nanotechnology. In this respect, using naturalresources,especially plant extract has attracted lots of attention; plant extract is أکثر

Development of green and efficient procedures for the synthesis of metallic nanoparticleshas emerged as a significant topic in the field of nanotechnology. In this respect, using naturalresources,especially plant extract has attracted lots of attention; plant extract is a promisingalternative to traditional and chemical techniques. The plant Mucuna pruriens L. contains highconcentration of L-dopa in the seeds; it has been used as a nerve tonic for nervous systemdisorders including Parkinson’s disease. In this work, a rapid and efficient synthesis of stablemagnesium oxide nanoparticles (MgO NPs) using aqueous extract of Mucuna pruriens seedswere reported. The biologically synthesized MgO NPs were characterized by UV–Visible andFourier transform infrared (FTIR) spectroscopy as well as X-ray diffraction (XRD), scanning andtransmission electron microscopy (SEM and TEM). The potential of MgO nanoparticles in thedegeneration of methyl orange (MO) and methylene blue (MB) dyes were assessed in differentconditions. The results of these investigations showed that the synthesized MgO NPs havea good catalytic activity in the removal of both dyes. Biological study of biosynthesized MgONPs showed moderate antibacterial property against four strains of bacteria and a very goodantioxidant activity. تفاصيل المقالة

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12 - Uses, phytochemistry and biological activity of Piper genus: a review
کلمن بادیکو گدئون بونگو کوتو نبولوئا نادگ نومبی پائولین کاپپولا ماری کلاری یاندو پیوس پیانا تئوفیل بمبا

10.30495/medherb.2023.702258

Background & Aim: Piper genus comprises more than 2000 species, mainly found in Asia and Africa. About 40 species are mentioned in the literature and only a small proportion of these species have been studied in depth. The aim of this review is to present data on th أکثر

Background & Aim: Piper genus comprises more than 2000 species, mainly found in Asia and Africa. About 40 species are mentioned in the literature and only a small proportion of these species have been studied in depth. The aim of this review is to present data on the traditional uses, biological activities and the chemical composition of different Piper species.Experimental: Several databases like PubMed, PubMed Central, Science Direct, DOAJ, etc.), were used for the search. The term Piper or the scientific names of different species or the combination of terms such as biological activity, phytochemistry and uses with the scientific names or the word "Piper" were used as keywords in the literature search.Results: Species of the Piper genus are of great economic value as they can be used in various sectors such as food, traditional medicine, in the control of certain infectious diseases, crop pest control or in the pharmaceutical industry. Some species are considered a significant source of essential oils. About 400 chemical compounds have been isolated from Piper species, and the alkaloids are the most important group of secondary metabolites; and piperine is the main active alkaloid reported. Moreover, the literature indicates that these species present several biological properties like anti-inflammatory, antioxidant, antibacterial, antifungal, antiplasmodial, analgesic, immunomudatory, antitumour, insecticide, larvicide, amoebicide, antiviral, etc.Recommended applications/industries: The species from Piper genus can be widely used both as a condiment and as medicines to relieve several health problems. However, further studies should be carried out to justify the uses of the less scientifically explored species of Piper genus, and to determine the mechanisms of action or the pharmacokinetics of the active principles already identified and probable synergies between the alkaloids and other chemical groups to evaluate the digestibility and toxicity of extracts from these species. تفاصيل المقالة

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13 - Phenolic compounds and antioxidant activity in seven populations of Lepidium sativum L. Leaves
نیلوفر جلوه گر سیدمهدی میری خداداد مصطفوی عبدالله محمدی

10.30495/medherb.2023.702368

Background & Aim: Garden cress (Lepidium sativum L.) is anannual herbaceous species native to Egypt and south west Asia. The leaves of L. sativum possesse various medicinal properties. This study was conducted to evaluate the diversity of phytochemical constituents أکثر

Background & Aim: Garden cress (Lepidium sativum L.) is anannual herbaceous species native to Egypt and south west Asia. The leaves of L. sativum possesse various medicinal properties. This study was conducted to evaluate the diversity of phytochemical constituents of seven populations of L. Sativum from Iran.Experimental: The crude extracts of L. sativum populations leaves were obtained with methanol and were evaluated for the total phenol content, total flavonoid content, antioxidant activity using DPPH radical scavenging assay, and phenolic compounds by HPLC analysis.Results: The total phenolic content ranged from 1.25 to 2.36 mg GAE/g extract and the total flavonoid content was 0.74- 1.61 mg QE/g extract. Chlorogenic acid was the most abundant phenolic acid, followed by ferulic and caffeic acids. The content of kaempferol flavonoid was also 5.2-fold of quercetin. Leaf extracts of Tabriz and Kerman populations exhibited higher yields of phenolic constituents and antioxidant activity. The total phenolic content was positively correlated to total flavonoid content and phenolic acids (except caffeic acid) and negatively correlated to DPPH free radical scavenging activity (IC50). A negative correlation was found among total flavonoid content, caffeic acid, p-coumaric acid and ferulic acid with precipitation and relative humidity.Recommended applications/industries: Our research is the first report to study the phytochemical profiles and antioxidant activity in different Iranian populations of L. sativum leaves for their health benefit. تفاصيل المقالة

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14 - Synthesis, Characterization, and Biological Activity of Chromium Complexes as Efficient and Novel Catalysts for Direct Synthesis of Carbonyl Compounds from Benzyl/Cycloalkyl Bromides in Water under Aerobic Oxidation
Samaa Raoof Fadia Ahmed Alyaa Al-barwari Mohanad Saleh

10.30495/ijc.2022.689761

The oxidation process of benzylic halides especially benzylic bromide to corresponding carbonyl compounds such as aldehydes and ketones is a worthwhile and important organic reaction in industrial and laboratory synthetic organic chemistry. In the present study, an effi أکثر

The oxidation process of benzylic halides especially benzylic bromide to corresponding carbonyl compounds such as aldehydes and ketones is a worthwhile and important organic reaction in industrial and laboratory synthetic organic chemistry. In the present study, an efficient and novel method to obtain carbonyl compounds using benzyl bromide with a catalytic amount of chromium complexes in water under aerobic conditions was reported. The six types of chromium complexes were prepared via the reaction mixture of four ligands. The prepared ligands and chromium complexes were characterized using Fourier transform spectroscopy (FT-IR), elemental analysis, molar conductivity, and magnetic moment, as well as UV-Vis spectroscopy. Different benzyl bromide derivatives were selected with both electron-donating groups and electron-withdrawing groups at –ortho, -meta, and –para positions. Under the optimum conditions, the corresponding benzaldehyde derivatives were obtained in moderate to excellent yields. In addition, the biological activity of the prepared chromium complexes was checked. تفاصيل المقالة

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15 - استخراج و شناسایی ترکیبات طبیعی عصاره ی جلبک قهوه ای Cystoseira trinodis
مهسا ایلخانی

در مطالعه حاضر، ترکیباتطبیعی استخراج شده از جلبک قهوه ای Cystoseira trinodis مورد بررسی قرار گرفته است. عملیات عصاره گیری جلبک مورد نظر پس از جمع آوری از سواحل خلیج فارس در بوشهر بوسیله ی سه حلال دی اتیل اتر، اتانول و نرمال هگزان انجام گردید و توسط دستگاه Rotary evapora أکثر

در مطالعه حاضر، ترکیباتطبیعی استخراج شده از جلبک قهوه ای Cystoseira trinodis مورد بررسی قرار گرفته است. عملیات عصاره گیری جلبک مورد نظر پس از جمع آوری از سواحل خلیج فارس در بوشهر بوسیله ی سه حلال دی اتیل اتر، اتانول و نرمال هگزان انجام گردید و توسط دستگاه Rotary evaporator تحت خلاء تغلیظ شد. سپس ترکیبات با استفاده از دستگاه کروماتوگرافی گازی و طیف سنج جرمی GC/MS جداسازی و شناسایی شد.١۶ ترکیب H-Pyrazole-4,5-dihydro-4,5-dimethyl (2.36%)، Decane (1.24%)، Limonene (1.80%)، Dodecane (1.06%)، (3.58%) 1-alpha-Terpineol، (1.48%) naphthalene،Tridecane (0.79%)، (1.25%) N-tetradecane، Isolongifolene (0.99%)، Tetradecamethylcycloheptasiloxane (1.16%)، (1.00%) 1,2-Benzenedicarboxylic acid، (5.57%) Octadecane Heptadecane (35.55%)، α-pinene (15.84%) و Hexadecanoic acid (5.57%) ترکیبات اصلی شناسایی شد. از میان ترکیبات شناسایی شده α-pinene و Heptadecane در بررسی مواردی همچون خواص ضد ویروسی، ضد توموری، ضد قارچی و ضد باکتریایی می تواند مورد استفاده قرار گیرد. تفاصيل المقالة

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16 - ارزیابی فعالیت زیستی گیاهان دارای ویژگی ضدسرطانی با استفاده از روش سنجش میزان کشندگی میگوی آب شور
زهرا پورفریدون قصرالدشتی چیداندا شَرما

سابقه و هدف: یکی از اهداف پژوهش&zwnj;های جدید شناسایی گیاهان دارای ویژگی&zwnj;های درمانی است. هدف از این پژوهش، ارزیابی ویژگی ضدسرطانی گروهی از گیاهان با روش غربال&zwnj;گری سریع میزان کشندگی میگوی آب شور است. مواد و روش&zwnj;ها: این پژوهش به صورت تجربی بر روی 19 نمونه أکثر

سابقه و هدف: یکی از اهداف پژوهش&zwnj;های جدید شناسایی گیاهان دارای ویژگی&zwnj;های درمانی است. هدف از این پژوهش، ارزیابی ویژگی ضدسرطانی گروهی از گیاهان با روش غربال&zwnj;گری سریع میزان کشندگی میگوی آب شور است. مواد و روش&zwnj;ها: این پژوهش به صورت تجربی بر روی 19 نمونه گیاه تهیه شده از کمپ دانشگاه بنگلور، دارای فعالیت ضد&zwnj;سرطانی ناشناخته و 3 نمونه گیاه شناخته شده دارای ویژگی ضدسرطانی به عنوان کنترل انجام شد. پس از عصاره&zwnj;گیری گیاهان یاد شده با روش کشندگی میگوی آب شور فعالیت زیستی آن&zwnj;ها مورد ارزیابی قرار گرفت. یافته&zwnj;ها: نتایج نشان داد که 99/48%از گیاهان مورد پژوهش دارای فعالیت بازدارندگی بین 44 تا 002/44% می&zwnj;باشند. همچنین 70/47% از گیاهان مورد بررسی فعالیت بازدارندگی اندک داشتند. همچنین 3 نمونه کنترل، دارای فعالیت بازدارندگی بین 46/64 تا 100 را داشتند. نتیجه&zwnj;گیری: نتایج این پژوهش نشان داد که استفاده از روش کشندگی میگوی آب شور می&zwnj;تواند یکی از روش&zwnj;های سریع غربال&zwnj;گری گیاهان دارویی باشد. تفاصيل المقالة

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17 - Synthesis, spectral, thermal and biological properties of some novel coordination compounds of VO(IV) and biological 4[N-(4′-ethylbenzalidene) amino] antipyrine thiosemicarbazone and 4[N-(2′, 4′-dimethyl benzalidene amino] antipyrine thiosemicarbazone
Surendra Prasad Ram Kumar Agarwal Hans Raj Modi

In present studies the synthesis, characterization and biological properties ofoxovanadium(IV) coordination compounds of 4[N-(4′-ethylbenzalidene)amino] antipyrinethiosemicarbazone (EBAAPTS) and 4[N-(2′,4′-dimethylbenzalidene)amino] antipyrinethiosemic أکثر

In present studies the synthesis, characterization and biological properties ofoxovanadium(IV) coordination compounds of 4[N-(4′-ethylbenzalidene)amino] antipyrinethiosemicarbazone (EBAAPTS) and 4[N-(2′,4′-dimethylbenzalidene)amino] antipyrinethiosemicarbazone (DMBAAPTS) with the general composition VOX2L (X = C1-, Br-, I-, NO3-or NCS-) and VO(CIO4)2(L)H2O (L = EBAAPTS or DMBAAPTS) are described . All thecomplexes were characterized by elemental analyses, molar mass, molar conductance, magneticsusceptibility, infrared and electronic spectra. In all these complexes, both thethiosemicarbazones behave as neutral tridentate (N, N, S) ligands. The thermal properties of therepresentative complexes are also reported. The most probable geometry of the complexes isproposed. تفاصيل المقالة

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18 - Glutamic Acid as an Environmentally Friendly Catalyst for One-Pot Synthesis of 4H-Chromene Derivatives and Biological Activity
Farhad Hatamjafari

10.22034/jchr.2016.544138

In this study, the synthesis of 4H-chromenes of biological activity via a multicomponent reaction of dimedone, aromatic aldehydes and malononitrile catalyzed by glutamic acid as a catalyst was investigated. The structural features of the synthesized compounds were chara أکثر

In this study, the synthesis of 4H-chromenes of biological activity via a multicomponent reaction of dimedone, aromatic aldehydes and malononitrile catalyzed by glutamic acid as a catalyst was investigated. The structural features of the synthesized compounds were characterized by melting point, IR and 1H NMR analysis. The catalyst being reported here is cheap, safe to handle and the whole procedure is eco-friendly, Milder conditions, one-pot, excellent yields, operational simplicity and ecofriendly preparation are some advantages of this protocol. The compounds were screened for antimicrobial activity. The results showed that these compounds reacted against all the tested bacteria and fungi. تفاصيل المقالة

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19 - Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds
Rasim Farraj Muslim Ismaeel Majeed Suheb Eaid Saleh Marwan Mahmood Saleh Mustafa Nadhim Owaid Jalal Abdulkareem Abbas

10.22034/jchr.2022.688557

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's base أکثر

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J1-J5 derivatives. The compounds J1-J5 were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg ml-1 for J4 against the two pathogenic bacteria, while J1, J4, and J1 did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4), inhibited the development of both gram-negative and positive bacteria. تفاصيل المقالة

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