Characterization of bioactive compounds from Ficus vallis-choudae Delile (Moraceae)
الموضوعات :
Jean Jules Kezetas Bankeu
1
(Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon |
International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan)
Amadou Dawé
2
(Department of Chemistry, Higher Teacher Training College, University of Maroua, P.O. Box 55 Maroua, Cameroon)
Marius Mbiantcha
3
(Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon)
Guy Raymond Feuya
4
(Department of Chemistry, Faculty of Science, Scientific and Technical University of Masuku, Box. 943, Franceville, Gabon)
Iftikhar Ali
5
(Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan)
Marthe Aimée Tchuente Tchuenmogne
6
(Department of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon)
Lateef Mehreen
7
(Pharmaceutical Research Centre of Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan)
Bruno Lenta
8
(Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon)
Muhammad Ali
9
(International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan)
Augustin Silvère Ngouela
10
(Department of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon)
الکلمات المفتاحية: Biological activity, Bioactive compounds, antioxidant activity, isolation, Nkwenamide, <i>Ficus vallis-choudae</i> Delile,
ملخص المقالة :
Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity.
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