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حرية الوصول المقاله
1 - بررسی واکنشهای چند جزئی مرتبه بالا و کاربردهای بیولوژیکی محصولات آنها
جواد صفایی قمی سیما کلهر زهرا کلهرواکنشهای چندجزئی یکی از موفقترین روشها درزمینهٔ افزایش تنوع ساختاری و پیچیدگی مولکولی با استفاده از یک فرایند ساده است. این روش بهعنوان فرایندی درحالتوسعه برای تهیه ترکیبات دارویی، امکان گسترش بسیاری از ترکیبات شیمیایی را، با تنوع ساختاری بیشتر میدهد؛ بنابراین این أکثرواکنشهای چندجزئی یکی از موفقترین روشها درزمینهٔ افزایش تنوع ساختاری و پیچیدگی مولکولی با استفاده از یک فرایند ساده است. این روش بهعنوان فرایندی درحالتوسعه برای تهیه ترکیبات دارویی، امکان گسترش بسیاری از ترکیبات شیمیایی را، با تنوع ساختاری بیشتر میدهد؛ بنابراین این واکنشها که باعث تغییر و تحول اساسی در سنتز همه محصولات طبیعی شده؛ با سرعت زیادی در طول چند دهه گذشته گسترشیافته است. تا امروز بسیاری از واکنشهای جدید سه و چهارجزئی معرفیشدهاند؛ درصورتیکه نمونههایی از واکنشهای "مرتبه بالاتر" که در آن پنج یا حتی تعداد اجزاء بیشتری در ظرف واکنش باهم ترکیب میشوند، به شکل قابلملاحظهای کمتر بررسی شده است. در پایان قرن بیستم با افزایش مزیتهای "مولکولهای بیولوژیک فعال" ، بررسی کاربرد این واکنشها برای تهیهی "مولکولهای کوچک شبه دارویی" در صنایع و دانشگاهها افزایش یافته است. از مزیتهای این روش نسبت به روشهای دیگر، استفاده از مواد اولیه در دسترس، کمهزینه بودن، روش کار ساده، طیف گسترده کالا، ایجاد تنوع بالا در چند مرحله، سهولت اتوماسیون و... میباشد. هدف از این بررسی، توصیف تحولات ایجادشده در سالهای اخیر، ایدهها، چالشها و ارائه پیشنهادهایی برای پیشرفت در این زمینه میباشد. تفاصيل المقالة -
حرية الوصول المقاله
2 - Three-component Process for the Synthesis of Some Thiophene Derivatives Using Water as a Green Media
Ali Varasteh MoradiA convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields.A convenient and efficient three-component reaction to a one-pot synthesis of thiophene derivatives from activated acetylenic compounds and ethyl 2chloroacetoacetate in the presence of tetramethyl thiourea in water lead to the formation of thiophenes in good yields. تفاصيل المقالة -
حرية الوصول المقاله
3 - Application of ZnO Nanorods for the Synthesis of Thiazole Derivatives via Multicomponent Reactions in Water
Ali Varasteh MoradiSimple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields.Simple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields. تفاصيل المقالة -
حرية الوصول المقاله
4 - Solvent-Free Multicomponent Reactions of Dithiocarbamates, Activated Acetylenes and Isocyanides
F. Rostami-Charati Z. Hossaini R. HajinasiriAn efficient method to synthesis the 2H-pyrans using three component reactions of dithiocarbamats, activated acetylenes and isocyanides in water as the solvent is described. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without أکثرAn efficient method to synthesis the 2H-pyrans using three component reactions of dithiocarbamats, activated acetylenes and isocyanides in water as the solvent is described. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without using any catalyst. The mild reaction conditions and high yields of the products exhibit synthetic advantage of these methods. تفاصيل المقالة -
حرية الوصول المقاله
5 - Application of 2-methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as an efficient catalyst for the one-pot synthesis of hexahydroquinolines-3-carboxamides
Matin Asadi Masoud Mokhtary2-Methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as a novel room temperature ionic liquidwas synthesized and evaluated as a recoverable catalyst for the one-pot synthesis ofhexahydroquinoline-3-carboxamide derivatives by four-component reaction of arylaldehydes,dim أکثر2-Methylpyridinum p-toluenesulfonate ([2-MPy][p-TSA]) as a novel room temperature ionic liquidwas synthesized and evaluated as a recoverable catalyst for the one-pot synthesis ofhexahydroquinoline-3-carboxamide derivatives by four-component reaction of arylaldehydes,dimedone, acetoacetanilide and ammonium acetate in high to excellent yield in ethanol at 50 oC.The [2-MPy][p-TSA] catalyst was characterized via FT-IR, 1H NMR and 13C NMR spectroscopy.An environmentally benign procedure, four-component in one pot reaction, high yields and simplepreparation of the catalyst are some advantages of this work. تفاصيل المقالة -
حرية الوصول المقاله
6 - Water as the Green Media for the Synthesis of Isoquinoline Derivatives
Rokhsar Pahlavan Maedeh Najaf Zinatossadat HossainiAn efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. Themild reaction conditions and high yields of the products exhibit thegood synthetic a أکثرAn efficient synthesis of isoquinoline-2,3-dicarboxylates is described via one-pot reactions of isoquinoline and alkyl bromids with dialkyl acetylenedicarboxylates in water at 70oC. Themild reaction conditions and high yields of the products exhibit thegood synthetic advantageof these methods. تفاصيل المقالة -
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7 - SOLVENT-FREE SYNTHESIS OF PYRROL DERIVATIVES USING MULTICOMPONENT REACTIONS OF 1,3-DICARBONYLS, ACTIVATED CARBONYL COMPOUNDS, AND PRIMARY ALKYLAMINES
Faramarz Rostami-Charati Mehdi Shahraki Mohammad R Hosseini- Tabatabaei Zinatossadat Hossainione-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎.one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎. تفاصيل المقالة -
حرية الوصول المقاله
8 - SOLVENT-FREE SYNTHESIS OF PYRROL DERIVATIVES USING MULTICOMPONENT REACTIONS OF 1,3-DICARBONYLS, ACTIVATED CARBONYL COMPOUNDS, AND PRIMARY ALKYLAMINES
Faramarz Rostami-Charati Mehdi Shahraki Mohammad R. Hosseini- Tabatabaei Zinatossadat HossainiA one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎.A one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines and 1,3-dicarbonyls under solvent-free conditions is described‎. تفاصيل المقالة -
حرية الوصول المقاله
9 - A Simple and one-pot synthesis of imintriazole derivatives under Solvent-free conditions
Narges Ghasemi Parvaneh Firoozi Khanghah Mahboubeh Ghasemian DazmiriAn efficient synthesis of iminetriazole derivatives is described via an one-pot reaction between acid chlorides, 3-amino-2-butanone, primary amines and hydrazonoyl chloride under solvent-free conditions at room temperature in good yields. Also, the antimicrobial activit أکثرAn efficient synthesis of iminetriazole derivatives is described via an one-pot reaction between acid chlorides, 3-amino-2-butanone, primary amines and hydrazonoyl chloride under solvent-free conditions at room temperature in good yields. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst and products separation. تفاصيل المقالة -
حرية الوصول المقاله
10 - Preparation and characterization of ionic liquid functionalized SBA-15 and its application in the synthesis of 2,3-dihydroquinazolinones
Ghodsi Mohammadi Ziarani Leila Seiedakbari Parisa Gholamzadeh Alireza BadieiN-Methyl-N</em>ʹ-propyltrimethoxysillylimidazolium chloride was prepared as ionic liquid (IL) containing silylating agent and then used for modification of the internal surface of SBA-15 to gain a heterogeneous ionic liquid catalyst. Subsequently, the obtained SBA-IL wa أکثرN-Methyl-N</em>ʹ-propyltrimethoxysillylimidazolium chloride was prepared as ionic liquid (IL) containing silylating agent and then used for modification of the internal surface of SBA-15 to gain a heterogeneous ionic liquid catalyst. Subsequently, the obtained SBA-IL was characterized using various techniques, including SEM and TEM images, FT-IR, X-ray diffraction, TGA/DTA and BET analyses. It was found that the uniform SBA-15 particles, with a dimension of 400-800 nm, showed the decreasing in the pore volume, surface area, and pore diameter after modification process which is as a results of incorporating imidazole groups onto the pores of SBA-15. Afterward, catalytic activity of SBA-IL was investigated in the synthesis of 2,3-dihydroquinazolinones under solvent free condition. تفاصيل المقالة -
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11 - 1-(1-Propylsulfonic)-3-methylimidazolium chloride Brønsted acidic ionic liquid catalyzed one-pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives under solvent-free conditions
Sima Abbaspour Mogharab Torabi Jafroudi Shima Haghi Sohan RezayatiA rapid, green and efficient method for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives through a one-pot condensation of 2-naphthol with various aromatic aldehydes in the presences of several acidic ionic liquids including [PSMIM]Cl, [BMIM]HSO4, [BMIM]Cl, أکثرA rapid, green and efficient method for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives through a one-pot condensation of 2-naphthol with various aromatic aldehydes in the presences of several acidic ionic liquids including [PSMIM]Cl, [BMIM]HSO4, [BMIM]Cl, [BMIM]Br, and [BMIM]BF4 as organocatalysts and task-specific acidic ionic liquids (AILs) under solvent-free conditions is described. Compared with other synthetic methods, this new method has the advantages such as milder reaction conditions, good to excellent yields, short reaction times, and environmentally benign procedure. Also, 1-(1-Propylsulfonic)-3-methylimidazolium chloride [PSMIM]Cl acts as a catalyst under solvent-free conditions and can be recovered and reused six times without apparent loss of its catalytic activity. تفاصيل المقالة -
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12 - Nano TiO2@SiO2 as an efficient and reusable catalyst for the synthesis of multi-substituted imidazoles
Maryam Haghighi Kobra NikoofarNano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. T أکثرNano TiO2 supported on SiO2 (Nano TiO2@SiO2) as a solid Lewis acid, was described to be an effective and reusable catalyst for one-pot three-component reaction of benzil, aryl aldehydes and ammonium acetate for the synthesis 2-aryl-4,5-diphenyl-1H-imdazoles synthesis. To explore the high efficacy of the catalytic system the four-component cyclization of benzil, aryl aldehydes, ammonium acetate and anilines has also been accomplished successfully to obtain their 1,2-diaryl-4,5-diphenyl-1H-imidazole adducts. A plausible mechanism has also been expressed. The catalyst has been recovered and its reusability confirmed in 4 runs. High yields, simple operation, easy-work procedure, mild reaction conditions in addition with reusability are some advantages of this protocol. تفاصيل المقالة -
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13 - Boric acid as a highly efficient and reusable catalyst for the one-pot synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions
Sobhan Rezayati Rahimeh Hajinasiri Zahra Erfani Saman Rezayati Saeid Afshari-sharifabadAn efficient and simple procedure for the synthesis of 1,8-dioxo-octahydroxanthenes from the aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of boric acid [BO3H3 or B(OH)3] as an inexpensive and reusable catalyst is described. The sal أکثرAn efficient and simple procedure for the synthesis of 1,8-dioxo-octahydroxanthenes from the aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in the presence of boric acid [BO3H3 or B(OH)3] as an inexpensive and reusable catalyst is described. The salient features of this methodology are: the elimination of corrosive liquid acids, high yields, simple methodology, short reaction times, easy work-up and green heterogeneous catalyst. تفاصيل المقالة -
حرية الوصول المقاله
14 - تهیه و شناسایی یک نانوکاتالیست مؤثر و جدید اسیدی جامد و بررسی رفتار کاتالیستی آن در تهیه ′1-آریل-′2-(2-اکسوایندولین-3-ایل) اسپیرو[ایندولین-5،′3-پیرولین]-3،′2-دیاونها
کبری نیکوفر زهرا خادمی شیوا خانیدر این پژوهش، در مرحله اول پاراتولوئن سولفونیک اسید نشانده شده روی نانوسیلیکا بهعنوان یک نانوکاتالیست جدید به روش آسان و ساده تهیه شد. سپس، با روشهای اندازهگیری نقطه ذوب، طیفسنجی فروسرخ تبدیل فوریه (FT-IR)، میکروسکوپی الکترونی روبشی (SEM) و تجزیه عنصری با روش طیفسن أکثردر این پژوهش، در مرحله اول پاراتولوئن سولفونیک اسید نشانده شده روی نانوسیلیکا بهعنوان یک نانوکاتالیست جدید به روش آسان و ساده تهیه شد. سپس، با روشهای اندازهگیری نقطه ذوب، طیفسنجی فروسرخ تبدیل فوریه (FT-IR)، میکروسکوپی الکترونی روبشی (SEM) و تجزیه عنصری با روش طیفسنجی تفکیک انرژی (EDX)، شناسایی شد. در مرحله بعدی، بهمنظور تهیه مشتقهای ′1-آریل-′2-(2-اکسوایندولین-3-ایل) اسپیرو[ایندولین-5،′3-پیرولین]-3،′2-دیاونها، کارایی این نانوکاتالیست اسیدی جامد طی واکنش شبهتراکمی چهارجزیی، تکمرحلهای و تکظرف آنیلینها، ایساتینها و استون در حضور آب تحت شرایط بازروانی مورد بررسی قرار گرفت. استفاده از آب بهعنوان حلال سبز و در دسترس، بازدههای عالی فراوردهها، زمانهای کوتاه واکنش، عدم تولید فراوردههای جانبی که ممکن است از طریق تراکم آلدولی استون بهوجود آیند، قابلیت حمل آسان، ارزان قیمت بودن، غیرسمی بودن و توانایی بازیافت و استفاده دوباره کاتالیست حداقل در چهارچرخه بدون کاهش محسوس قدرت کاتالیستی، برخی از ویژگیهای بسیار مهم نانوکاتالیست تهیه شده در این پژوهش است. تفاصيل المقالة