آثار ناشی از آلودگی هوا بر عملکرد کلیه ها در شهر اصفهان

محورهای موضوعی : مدیریت و برنامه ریزی محیط زیست

سمانه محمدسلیمانی ¹ , مژگان احمدی ندوشن ² , مژگان مرتضوی ³ , فیروزه معین زاده ⁴ , رویا کلیشادی ⁵

1 - گروه محیط زیست، دانشگاه آزاد اسلامی، واحد اصفهان(خوراسگان)، اصفهان، ایران
2 - گروه محیط زیست، مرکز تحقیقات پسماند و پساب، دانشگاه آزاد اسلامی، واحد اصفهان(خوراسگان)، اصفهان، ایران
3 - مرکز تحقیقات بیماریهای کلیه اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
4 - مرکز تحقیقات بیماریهای کلیه اصفهان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
5 - مرکز تحقیقات رشد و نمو کودکان، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

تاریخ دریافت : 1402/04/16 تاریخ پذیرش : 1402/09/15 تاریخ انتشار : 1402/09/30

کلید واژه: عملکرد کلیه‌ها, سنتینل P5, رگرسیون خطی, کراتینین,

چکیده مقاله :

آلودگی هوای محیط به عنوان یکی از جدی‌ترین مسائل در سراسر جهان شناخته شده است. بخشي از اثرات آلودگي هوا بر سلامت انسان ناشي از نفوذ آلاينده‌ها به داخل بدن است كه می‌تواند منجر به اثرات بر دستگاه داخلی بدن گردد. به منظور انجام این مطالعه در شهر اصفهان، توزیع مکانی دی‌اکسید نیتروژن، منوکسید کربن، دی‌اکسید گوگرد و ازون حاصل از میانگین سالانه (1401) پروداکت¬های ماهواره سنتینل P5 بر حسب مول بر مترمکعب به‌دست آمد. نتایج حاصل از ارزیابی صحت تراکم آلاینده¬ها در محدوده قابل قبول 738/0 > R2 > 366/0 قرار داشت. همچنین سطح کراتینین خون و مختصات جغرافیایی محل سکونت 92 فرد بیمار نیز محاسبه و ارتباط مکانی آن¬ها با غلظت آلاینده¬ها توسط مدل رگرسیون خطی بررسی گردید. نتایج نشان داد که با افزایش غلظت هر یک از آلاینده¬ها، مقدار کراتینین خون نیز افزایش پیدا کرده است. بهترین مدل رگرسیون (234/0 = R2) برای مونوکسید کربن به‌دست آمد. مدل ساخته شده برای ازون نیز مقدار بسیار پایین ضریب تشخیص برابر (023/0) را از خود نشان داد. بر اساس نتایج اینطور به نظر می¬رسد که بالا رفتن غلظت این آلاینده¬ها باعث افزایش فشار خون و تحریک سیستم رنین- آنژیوتانسین- آلدوسترون شـده اسـت کـه مـی‌تـوانـد به اختـلال در کارکـرد کلیه و افزایش سطح کراتینین در خون منجر شود.

چکیده انگلیسی:

Ambient air pollution is recognized as one of the most serious issues around the world. Some effects of air pollution on human health is due to the penetration of pollutants into the body, which can lead to effects on the body's internal system. In order to carry out this study in Isfahan city, the spatial distribution of nitrogen dioxide, carbon monoxide, sulfur dioxide and ozone obtained from the annual average (2023) of Sentinel-P5 satellite products was obtained in terms of moles per cubic meter. The results of the pollutant density accuracy assessment were within the acceptable range of R2 > 0.366 > 0.738. Also, the level of blood creatinine and the geographical coordinates of the residence of 92 patients were also calculated and their spatial relationship with the concentration of pollutants was investigated by linear regression model. The results showed that with the increase in the concentration of each pollutant, the amount of blood creatinine also increased. The best regression model (R2 = 0.234) was obtained for carbon monoxide. The model made for ozone also showed a very low value of detection coefficient equal to (0.023). Based on the results, it seems that the increase in the concentration of these pollutants has caused an increase in blood pressure and stimulation of the renin-angiotensin-aldosterone system, which can lead to kidney dysfunction and an increase in the level of creatine in the blood.

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