Masoomeh Vahabi Shekarloo Articles List

List of Articles Masoomeh Vahabi Shekarloo

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1 - Formaldehyde Carcinogenicity Risk Assessment Using Benchmark Doses Approach Based on Genotoxic Effects in Occupational Exposure
Rezvan Zendehdel Masoomeh Vahabi
10.22034/jchr.2021.1928582.1296

Formaldehyde as a mass-produced chemical is used in many contexts. The genotoxicity and mutagenicity of formaldehyde are observed in different human body organs, such as buccal and white blood cells. The purpose of this study is to evaluate the lower confidence interval More

Formaldehyde as a mass-produced chemical is used in many contexts. The genotoxicity and mutagenicity of formaldehyde are observed in different human body organs, such as buccal and white blood cells. The purpose of this study is to evaluate the lower confidence interval of benchmark dose (BMDL) for genotoxic damage of formaldehyde in the workplace, according to published studies. Studies from occupational genotoxic damage of formaldehyde were retrieved using search in databases such as Google Scholar, Web of Science, and PubMed until April 2020. The search strategy was established based on the words “formaldehyde”, “genotoxicity”, “carcinogenicity”, “DNA damage,” and “occupational exposure”. Based on dose-response data from three studies, benchmark dose (BMD) analysis was performed using EPA-BMD Software. Finally, five studies were included in the final BMDL conclusion. Polynomial and Hill models were used for BMDL evaluation in three studies, and BMD of formaldehyde was estimated between 0.062 to 0.26 ppm. The lowest level of BMDL (0.028 ppm) in five studies was considered the basic value for genotoxicity risk assessment. The estimated BMDL is approximated to the time-weighted average of the National Institute for Occupational Safety and Health (NIOSH). This value is suggested for the evaluation of the carcinogenic properties of formaldehyde. Manuscript profile
Open Access Article
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2 - Evaluation of Control of Substances Hazard to Health (COSHH) Essentials Model by Measuring Occupational Exposure in a Chemical Production Industry
Masoomeh Vahabi Shekarloo Seyed Mohammad Sadat Zahra Moradpour Rezvan Zendehdel
10.22034/jchr.2023.1966650.1614

Control of Substances Hazard to Health (COSHH) Essentials is a simple, user-friendly matrix that provides risk-control solutions. Considering a large number of small enterprises under 25 workers in Iran and the lack of a suitable control banding tool, the COSHH Essentia More

Control of Substances Hazard to Health (COSHH) Essentials is a simple, user-friendly matrix that provides risk-control solutions. Considering a large number of small enterprises under 25 workers in Iran and the lack of a suitable control banding tool, the COSHH Essentials can be considered an appropriate option. The purpose of the present experimental semi qualitative study was to evaluate the validity of the COSHH Essentials tool. Six processes were selected from a chemical products industry, including the production of silicone glue, polishing, PVC glue, Grease, Twin glue filling, and quality control. Amorphous silica and toluene concentrations were monitored using NIOSH 0600 and NIOSH 1501 in the ambient air of operators. The predicted exposure range (PER) was obtained by combining the control strategies available at the sampling time with exposure predictor (EP) bands in the COSHH Essentials, then compared to silica and toluene concentrations in the air.All exposure data were within the PER for amorphous silica dust and lower or within the PER for toluene. Compared to the acceptable concentration range in hazard bands, the threshold limit value (TLV) for respirable dust is within the acceptable concentration range, while toluene TLV exceeded it. COSHH Essentials is a conservative and safe tool, especially in liquids. Due to its simplicity, ‎employers and health center experts can use the COSHH tool successfully for small enterprises or ‎as a screening tool before a comprehensive risk assessment. Manuscript profile

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List of Articles Masoomeh Vahabi Shekarloo