Chalcone

دسترسی آزاد مقاله

1 - Preparation of (MWCNTs)-COOH/CeO2Hybrid as an Efficient Catalyst for Claisen-Schmidt Condensation
Tahereh Heidarzadeh Navabeh Nami Daryoush Zareyee

Acid functionalized multi-walled carbon nanotubes/CeO2 (MWCNTs)-COOH/CeO2 hybrid was fabricated by the reaction of functionalized (MWCNTs)-COOH and Ce(NO3)2.6H2O in acetic acid. Synthesis of CeO2 nanoparticles and their conjugation on the surface of (MWCNTs)-COOH have b چکیده کامل

Acid functionalized multi-walled carbon nanotubes/CeO2 (MWCNTs)-COOH/CeO2 hybrid was fabricated by the reaction of functionalized (MWCNTs)-COOH and Ce(NO3)2.6H2O in acetic acid. Synthesis of CeO2 nanoparticles and their conjugation on the surface of (MWCNTs)-COOH have been confirmed by FT-IR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Energy-dispersive X-ray spectroscopy (EDX). The modification of MWCNTs-COOH with CeO2 produced an efficient catalyst for the Claisen–Schmidt condensation, soa large variety of chalconeswere obtained in high yield using a catalytic amount of (MWCNTs)-COOH/CeO2 hybrid (5 mol%). پرونده مقاله

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2 - An Efficient Protocol for Synthesis of 2-amino-3cyanopyridine Derivatives using Nano-modified SBA-15
Behrooz Mirza Neda Nasseri

Condensation reaction of chalcones with malononitrile and ammonium acetate in the presence of the green nano-modified SBA-15 affords the corresponding 2-amino-3-cyanopyridine derivatives in excellent yield. This approaches claimed to be an environment friendly protocol چکیده کامل

Condensation reaction of chalcones with malononitrile and ammonium acetate in the presence of the green nano-modified SBA-15 affords the corresponding 2-amino-3-cyanopyridine derivatives in excellent yield. This approaches claimed to be an environment friendly protocol as it afforded some advantages such as excellent yields and cleaner reaction. پرونده مقاله

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3 - Synthesis and In Vitro Cytotoxic Activity of Novel [1,3] Dioxolo[4,5-g]Chromen-8-ones as a Chalcone-Like Agent
Eskandar Alipour Zinatsadat Mousavi Tina Shojaie Susan Kabudanian Ardestani

In this investigation, new structures based on homoisoflavonoids were designed. Homoisoflavonoids are considered as an important class of flavonoids with various biological properties such as cytotoxicity. A new series of benzylidene-6,7-dihydro-8H-[1,3]dioxolo[4,5-g] c چکیده کامل

In this investigation, new structures based on homoisoflavonoids were designed. Homoisoflavonoids are considered as an important class of flavonoids with various biological properties such as cytotoxicity. A new series of benzylidene-6,7-dihydro-8H-[1,3]dioxolo[4,5-g] chromen-8-one derivatives were developed and their cytotoxic activities evaluated for all compounds on three human breast cancer cell lines. Benzo[d][1,3]dioxol-5-ol was chosen as a substrate and reacted with 3-bromopropanoic acid to form an intermediate which turns to 6,7-dihydro-8H-[1,3]dioxolo[4,5-g]chromen-8-one after Feridel-Crafts reaction with oxalyl chloride. In the end, title compounds were produced by aldol condensation of later compound under acidic condition with aromatic aldehydes in moderate yields. Eight novel derivatives were tested for their activities against all human breast cancer cell lines including MCF- 7, T47-D and MDA-MB-231 using MTT assay. After all tests on synthesized products, we can reach to this point that (E)-7-(3-bromo-4,5-dimethoxybenzylidene)-6,7-dihydro-8H-[1,3] dioxolo[4,5-g]chromen-8-one 4a presents the highest cytotoxicity in all three cell lines as a result of its shorter aliphatic tail in benzylidene moiety. پرونده مقاله

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4 - Calcium Chloride catalyzed Intramolecular Oxa Michael addition of 2’-Hydroxychalcone to Flavanone
Pramod Kulkarni

An efficient cyclization of 2’-hydroxychalcone to flavanone using calcium chloride as a catalyst was developed. The scope of the reaction was studied with substituted 2’-hydroxychalcone and these chalcones was converted into corresponding flavanone in good y چکیده کامل

An efficient cyclization of 2’-hydroxychalcone to flavanone using calcium chloride as a catalyst was developed. The scope of the reaction was studied with substituted 2’-hydroxychalcone and these chalcones was converted into corresponding flavanone in good yield. The merits of this method are inexpensive and easily available catalyst, easy workup procedure, avoid use of toxic solvent پرونده مقاله

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5 - One pot synthesis of conjugated chalcone-quinoxalines using an organocatalyst under ultrasonic mediation
Kiana Darvishi

Ultrasonic irradiation was effectively used for the synthesis of one pot chalcon-quinoxaline derivatives with high efficiency and short time. The products are obtained by mixing parahydroxy acetophenone and various aldehydes or parahydroxy benzaldehyde with different ke چکیده کامل

Ultrasonic irradiation was effectively used for the synthesis of one pot chalcon-quinoxaline derivatives with high efficiency and short time. The products are obtained by mixing parahydroxy acetophenone and various aldehydes or parahydroxy benzaldehyde with different ketones and then adding 2,6-dichloroquinoxaline, in the presence of catalytic amounts of pyrrolidine as a organocatalyst and DMF as a solvent. These conjugated chalcon-quinoxaline derivatives have been shown to have good anticancer activity. پرونده مقاله

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6 - Fe(HSO4)3/SiO2: An efficient and heterogeneous catalyst for cyclization of 2- aminochalcones to 2- aryl-2,3- dihydroquinolin- 4(1H)- ones
Hossein Eshghi Mohammad Rahimizadeh Seyed Mohsen Mousavi

Silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1H)-ones. This intramolecular aza Michael reaction was carried out in high yields using chalcones bearing of electro چکیده کامل

Silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1H)-ones. This intramolecular aza Michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. The catalyst is reusable without significant decreases in its activity after four times recycling.The present study represents the application of silica supported ferric hydrogensulfate as catalyst for the aza-Michael cyclization of 2-aminochalcones to the corresponding 2-aryl-2,3-dihydroquinolone derivatives. Therefore, the simplicity of the procedure, the mildness of the reaction conditions, high yields, the ease of catalyst separation and its re-usability demonstrates the ability of this method. پرونده مقاله

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7 - -Fe2O3@SiO2-PW12 nanoparticles: Highly efficient catalysts for the synthesis of pyrazoline derivatives
Hamid Aliyan Razieh Fazaeli Nafiseh Tajsaeed

A new type of magnetically-recoverable catalyst was synthesized by the immobilization of H3PW12O40 on the surface of silica-encapsulated -Fe2O3 nanoparticles. A series of novel 1,3,5-triaryl pyrazoline derivatives has been synthesized by the reaction of chalcone and ph چکیده کامل

A new type of magnetically-recoverable catalyst was synthesized by the immobilization of H3PW12O40 on the surface of silica-encapsulated -Fe2O3 nanoparticles. A series of novel 1,3,5-triaryl pyrazoline derivatives has been synthesized by the reaction of chalcone and phenylhydrazine in the presence of the -Fe2O3@SiO2-PW12nanoparticles, in high yields. The structures of compounds obtained were determined by IR and 1H NMR spectra. -Fe2O3@SiO2-PW12was recycled and no appreciable change in activity was noticed after three cycles. پرونده مقاله

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8 - Synthesis and in-vitro antimicrobial screening of 3-cinnamoyl coumarin and 3-[3-(1H-indol-2-yl)-3-aryl-propanoyl]-2H-chromen-2-ones
Somnath Gholap Umesh Deshmukh Macchindra Tambe

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good چکیده کامل

An efficient synthesis of some novel coumarin derivatives via 1, 4- Michael addition of indole to coumarin chalcones catalyzed by cellulose sulphonic acid (CSA) under solvent free conditions is described. The corresponding Michael addition products were obtained in good to excellent yield. The synthesized compounds were screened for their antibacterial activity against E. coli, S. aureus and anti-fungal activity against C. albicans. All the synthesized compounds show moderate to good antimicrobial activity. پرونده مقاله

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9 - Chalcone Isomerase Gene Expression in Different Stages of <i>Petunia Hybrida</i> Flowering and Various Flower Colors
Fatemeh Keykha Akhar Abdolreza Bagheri Nasrin Moshtaghi Masoud Fakhrfeshani

Petunia (Petunia hybrida) is one of the important plants in horticultural industry. This plant is being used as a model ornamental plant and is one of the most important plants in floriculture market. Flavonoids are the main pigment in this plant. So, genetic engineerin چکیده کامل

Petunia (Petunia hybrida) is one of the important plants in horticultural industry. This plant is being used as a model ornamental plant and is one of the most important plants in floriculture market. Flavonoids are the main pigment in this plant. So, genetic engineering with the goal of color alteration in petunia is focused on flavonoids. To gain a global perspective on genes differentially expressed in petunia’s flowers pigment pathway, we investigated the expression of chalcone isomerase (chi) as an essential gene in biosynthesis pathway of pigment production in different types of flower color of petunia and various stages of flowering in this plant. Also, we measured the concentration of total flavonoids, anthocyanins and naringenin to evaluate the probably relationship between the expression profile of chi gene and the concentration of mentioned pigments. The results indicated that chalcone isomerase expression had different profile in different petal color of P. hybrida. So that, the most chi expression observed in red petunia flowers. Naringenin concentrations was the most value in this color flower. In comparison of flowering stages, stage 1, had the most expression. In other words, when the flowers fully closed (bud stage), chi expression and concentration was in the highest value. Our results showed that chi is a key gene in pigment biosynthesis pathway so that in absence of this gene, pigment pathway will be stopped. Identification of effective genes in different pathways of secondary metabolite production will assist in accurate selection of genes for genetically modification of pathways and production of various metabolites. پرونده مقاله

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10 - Synthesis, Anti-bacterial and Anti-fungal evaluation of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4 yl)acrylamide
Pravinkumar M. Patel Ashvin D. Panchal

The Series of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide compounds were prepared byreaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by Claisen-Schmidt Condensation reactionwith different aromatic aldehydes. The structures of new compounds چکیده کامل

The Series of 3-(Substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide compounds were prepared byreaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by Claisen-Schmidt Condensation reactionwith different aromatic aldehydes. The structures of new compounds were confirmed by IR, 1H-NMR and13C-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with thestandard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activitycompared to standard drugs. پرونده مقاله

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11 - Synthesis and Biologically Activity of Novel 2- Chloro -3-Formyl -1,5-Naphthyridine Chalcone Derivatives
Alaa I. Ayoob Ghufran Th. Sadeek Mohanad Saleh

10.22034/jchr.2022.688560

A new and efficient procedure has been described for the synthesis of 2- chloro-1,5-Naphthyridine-3-carbaldehyde(1) from the condensation of N-(pyridine-3-yl) acetamide in presence of dimethylformamide and phosphorous oxychloride through Vilsmeir – Haack cyclizati چکیده کامل

A new and efficient procedure has been described for the synthesis of 2- chloro-1,5-Naphthyridine-3-carbaldehyde(1) from the condensation of N-(pyridine-3-yl) acetamide in presence of dimethylformamide and phosphorous oxychloride through Vilsmeir – Haack cyclization. The condensation of compound (1) with acetophenone, p-hydroxy acetophenone, pyridine-3-acetyl, furan-2-acetyl, and indole-2-acetyl in the presence of ethanolic sodium hydroxide through Claisen- Schmidt condensation give quinolinyl chalcones (2a-e) and it's further treated with dimethyl sulfoxide in the presence of iodine to obtained iodo chalcone compounds (3a-e). The smooth and selective bromination of chalcones (2a-e) affords dibromide compounds (4a-e). The structure of prepared compounds was identification by spectral and physical methods. Synthesized compounds (4a, 3e, 3b and 4e) give good biological activity from against Staphylococcus aureus and Staphylococcus epidermidis and moderate activity against Escherichia Coli and Proteus Vulgaris. پرونده مقاله

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12 - بررسی تاثیر ترانس‌چالکون بر روی فیبریلاسیون پروتئین انسولین
ماریا امیدی شاهسوندی پریچهره یغمایی شهین احمدیان آزاده ابراهیم حبیبی

10.22034/ascij.2023.1989037.1499

فیبریل های آمیلوئیدی تجمعات رشته مانندی هستند که از باز شدن ساختار طبیعی و بدتاخوردگی انواع مختلف پپتیدها و پروتئین ها بوجود می آیند. این تجمعات آمیلوئیدی با برخی از بیماری ها نظیر بیماری های تحلیل برنده عصبی و سیستماتیک از قبیل آلزایمر، پارکینسون و دیابت نوع دو در ارتب چکیده کامل

فیبریل های آمیلوئیدی تجمعات رشته مانندی هستند که از باز شدن ساختار طبیعی و بدتاخوردگی انواع مختلف پپتیدها و پروتئین ها بوجود می آیند. این تجمعات آمیلوئیدی با برخی از بیماری ها نظیر بیماری های تحلیل برنده عصبی و سیستماتیک از قبیل آلزایمر، پارکینسون و دیابت نوع دو در ارتباط می باشند. هدف از این مطالعه بررسی اثرات مهاری ترانس‌چالکون در مهار فرایند فیبریلاسیون انسولین (پروتئین مدل) می باشد. در مرحله اول با استناد به مطالعات انجام شده، شرایط مناسب برای تشکیل فیبریل های آمیلوئیدی برای پروتئین مدل مد نظر ما فراهم شد. سپس پپتید انسولین در حضور و عدم حضور ترانس‌چالکون به مدت 24 ساعت در شرایط تشکیل تجمعات آمیلوئیدی انکوبه شد و فیبریل های تشکیل شده با تکنیک های مختلف از جمله مطالعه تغییرات جذب نوری کنگورد با تکنیک اسپکتروسکوپی، تصاویر حاصل از میکروسکوپ الکترونی گذاره (TEM) و تصویربرداری و آنالیز تجمعات آمیلوئیدی با میکروسکوپ فلورسان بررسی شدند در نهایت، با استفاده از روش داکینگ مولکولی توسط نرم افزار AutoDock برهمکنش های احتمالی ترکیب ترانس‌چالکون با پپتید انسولین تحلیل شد. نتایج حاصل از پژوهش، کاهش قابل ملاحظه تجمعات آمیلوئیدی را در نمونه تغییر داده شده نسبت به نمونه شاهد نشان داد. پرونده مقاله

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13 - تأثیر ماده ترانس چالکون بر سرطان سینه القا شده در موش های نژاد BALB/c
فاطمه صبری پریچهره یغمایی آزاده ابراهیم حبیبی شیوا ایرانی

سرطان رشد غیرقابل کنترل سلول هاست که سرطان سینه یکی از انواع آن بوده و درمان اصلی آن که شیمی درمانی است با عوارض جانبی همراه است. امروزه استفاده از مواد طبیعی مانند چالکون ها در درمان سرطان گسترده شده است. هدف این بررسی القای آپوپتوز با داروهای ترانس چالکون در سلول های چکیده کامل

سرطان رشد غیرقابل کنترل سلول هاست که سرطان سینه یکی از انواع آن بوده و درمان اصلی آن که شیمی درمانی است با عوارض جانبی همراه است. امروزه استفاده از مواد طبیعی مانند چالکون ها در درمان سرطان گسترده شده است. هدف این بررسی القای آپوپتوز با داروهای ترانس چالکون در سلول های سرطان سینه 4T1 و روی موش های نژاد Balb/c بوده است. سمیت دارو با تستMTT در زمان های 24 و 48 ساعت و غلظت های 20، 30، 40 و50 میکرومول (µM) سنجیده شد. پس از تیمار موش های توموری بررسی هماتوکسیلین- ائوزین انجام گرفت. سپس معناداری نتایج باSPSS وANOVA با سطح معناداری 05/0p< بررسی گردید. نتایج تستMTT ترانس چالکون میزان سمیت 50 درصد دارویی را در زمان 48 ساعت در تمامی غلظت ها نشان داده است. در بررسی هیستولوژیک نیز آپوپتوز مشاهده شد. بنابراین، می توان نتیجه گرفت که داروهای ترانس چالکون می توانند به عنوان روش مناسبی برای درمان سرطان سینه باشند. پرونده مقاله

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14 - تأثیر ماده نیتروچالکون بر سرطان سینه القا شده در موش‌های نژاد BALB/c
فاطمه صبری پریچهره یغمایی آزاده ابراهیم حبیبی شیوا ایرانی

سرطان رشد غیرقابل کنترل سلول ها می باشد و سرطان سینه یکی از انواع آن بوده که روش اصلی درمان آن شیمی درمانی است که با عوارض جانبی همراه می باشد. امروزه استفاده از مواد طبیعی مانند چالکون ها در درمان سرطان گسترده شده است. هدف این بررسی القای آپوپتوز با داروهای نیتروچالکون چکیده کامل

سرطان رشد غیرقابل کنترل سلول ها می باشد و سرطان سینه یکی از انواع آن بوده که روش اصلی درمان آن شیمی درمانی است که با عوارض جانبی همراه می باشد. امروزه استفاده از مواد طبیعی مانند چالکون ها در درمان سرطان گسترده شده است. هدف این بررسی القای آپوپتوز با داروهای نیتروچالکون در سلول های سرطان سینه 4T1و روی موش های نژاد Balb/c بوده است. سمیت دارو با روش MTT assay در زمان های 24 و 48 ساعت و غلظت های 20، 30، 40 و 50 میکرومولار سنجیده شد. پس از تیمار موش های توموری، بررسی های بافتی شناسی با رنگ آمیزی هماتوکسیلین-ائوزین انجام گرفت. سپس معناداری نتایج با SPSS و ANOVA با 05/0 > p بررسی گردید. نتایج سنجش MTT در نیتروچالکون، میزان سمیت 50 درصد دارویی را در زمان 24 ساعت در تمامی غلظت ها نشان داده است. در بررسی هیستولوژیک، آپوپتوز نیز مشاهده شد. بنابراین، می توان نتیجه گرفت که داروهای نیتروچالکون می توانند گزینه ی مناسبی برای درمان سرطان سینه باشند. پرونده مقاله

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