One pot synthesis of conjugated chalcone-quinoxalines using an organocatalyst under ultrasonic mediation

محورهای موضوعی : Journal of Chemical Reactivity and Synthesis

Kiana Darvishi ¹ (Department of chemistry, Takestan Branch, Islamic Azad University, Takestan, Iran)

تاریخ دریافت : 1400/12/23 تاریخ پذیرش : 1400/12/23 تاریخ انتشار : 1400/09/10

کلید واژه: Chalcone, Quinoxaline, Ultrasonic mediation, Organocatalysts, Chalcon-quinoxaline,

چکیده مقاله :

Ultrasonic irradiation was effectively used for the synthesis of one pot chalcon-quinoxaline derivatives with high efficiency and short time. The products are obtained by mixing parahydroxy acetophenone and various aldehydes or parahydroxy benzaldehyde with different ketones and then adding 2,6-dichloroquinoxaline, in the presence of catalytic amounts of pyrrolidine as a organocatalyst and DMF as a solvent. These conjugated chalcon-quinoxaline derivatives have been shown to have good anticancer activity.