One pot synthesis of conjugated chalcone-quinoxalines using an organocatalyst under ultrasonic mediation
الموضوعات : International Journal of Heterocyclic Chemistry
1 - Department of chemistry, Takestan Branch, Islamic Azad University, Takestan, Iran
الکلمات المفتاحية: Chalcone, Quinoxaline, Ultrasonic mediation, Organocatalysts, Chalcon-quinoxaline,
ملخص المقالة :
Ultrasonic irradiation was effectively used for the synthesis of one pot chalcon-quinoxaline derivatives with high efficiency and short time. The products are obtained by mixing parahydroxy acetophenone and various aldehydes or parahydroxy benzaldehyde with different ketones and then adding 2,6-dichloroquinoxaline, in the presence of catalytic amounts of pyrrolidine as a organocatalyst and DMF as a solvent. These conjugated chalcon-quinoxaline derivatives have been shown to have good anticancer activity.
