Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat

Subject Areas : Ethnopharmacology

Md Rafiul Haque ¹ , Md Afroz Ahmad ² , Kamran Ashraf ³ , Md Habban Akhter ⁴ , Mohammad Jameel ⁵ , Abuzer Ali ⁶ , Wasim Akhtar ⁷ , Monika Dhaka ⁸ , Kavita Rana ⁹

1 - School of Pharmacy, Al-Karim University, Bihar, India|School of Pharmaceutical Education and Research, Hamdard University, Hamdard Nagar, New Delhi 62, India
2 - Department of Prmhacology, Integral University, Lucknow (U.P), India
3 - Faculty of Pharmacy, University Teknologi MARA (UITM), Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malasiya
4 - School of Pharmaceutical and population Health information (SoPPHI), DIT University, Dehradun 248009, India
5 - RRIUM, CCRUM Aligarh (UP), India
6 - Department of Pharmacognosy, College of Pharmacy, Taif University, P.O. box 21944, Saudi Arabia
7 - School of Pharmacy, Al-Karim University, Bihar, India
8 - School of Pharmaceutical and population Health information (SoPPHI), DIT University, Dehradun 248009, India
9 - Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida (UP), India

Received: 2021-09-17 Accepted : 2021-12-11 Published : 2021-12-01

Keywords: Ajwain, insulin, Oxidative stress, Leptin, Nonalcoholic fatty liver disease,

Abstract :

In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p < 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p < 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models.

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