• صفحه اصلی
  • مروری بر گیاه دارویی کارلا ، خاصیت ضد سرطانی و ضد میکروبی

اشتراک گذاری

آدرس مقاله


کد مقاله : QAFJ-2209-1039 (R2) بازدید : 341 صفحه: 74 - 94

10.30495/qafj.2022.1966922.1039

20.1001.1.27833410.1401.2.1.5.0

نوع مقاله: پژوهشی

مروری بر گیاه دارویی کارلا ، خاصیت ضد سرطانی و ضد میکروبی

محورهای موضوعی : فصلنامه کیفیت و ماندگاری تولیدات کشاورزی و مواد غذایی

مریم بیگمی 1 , زهرا بیگمی 2 , صفورا بزی 3 , راضیه اویسی 4

1 - استادیار، گروه صنایع غذایی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران
2 - استادیار، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران
3 - استادیار،گروه زیست شناسی، دانشگاه پیام نور تهران، تهران، ایران
4 - کارشناسی ارشد ژنتیک، دانشکده علوم، گروه زیست شناسی، دانشگاه ملی زابل، زابل، ایران

تاریخ دریافت : 1401/06/12 تاریخ پذیرش : 1401/06/19 تاریخ انتشار : 1401/06/01

کلید واژه: ضد سرطان, ضد میکروبی, کارلا, ضد قارچی,

چکیده مقاله :

گیاه دارویی کارلا، با نام علمی Charantia Momordica گیاهی است گرمسیری و نیمه گرمسیری از تیره‌ی کدوئیان که به طور گسترده‌ای در مناطق آسیایی، آفریقایی و آمریکای جنوبی جهت استفاده از میوه‌ی آن کشت می‌گردد. گیاه کارلا دارای خواص ضدمیکروبی، ضد سرطان، ضد دیابت، ضد انعقاد، ضد بارداری و ضد دیابت است. بنابراین برنامه‌ریزی اصولی جهت توسعه فعالیت‌ها و حفاظت، احیا و بهره‌برداری از این گیاه در عرصه‌های طبیعی بنیازمند بررسی دقیق وضعیت موجود، شناخت پتانسیل‌های موجود در عرصه‌های زراعی و منابع طبیعی به عنوان خاستگاه اصلی گونه‌های بومی کشور و شناخت صحیح از محدودیت‌ها و چالش‌ها همگام با توسعه علمی فرآوری و مصرف آن می‌باشد. این مطالعه نیز در راستای شناخت پتانسیل‌های دارویی، فیتوشیمیایی، اقتصادی و ... گیاه مورینگا صورت گرفته است.این مطالعه نیز در راستای شناخت پتانسیل‌های دارویی، فیتوشیمیایی، اقتصادی و ... گیاه مورینگا صورت گرفته است. این مطالعه نیز در راستای شناخت پتانسیل‌های دارویی، فیتوشیمیایی، اقتصادی و ... گیاه مورینگا صورت گرفته است

چکیده انگلیسی:

Carla medicinal plant, with the scientific name Charantia Momordica, is a tropical and subtropical plant from the gourd family.which is widely cultivated in Asian, African and South American regions to use its fruit. Carla plant has anti-microbial, anti-cancer, anti-diabetic, anti-coagulant, anti-pregnancy and anti-diabetic properties. Therefore, basic planning for the development of activities and protection, restoration and exploitation of this plant in natural areas requires a detailed examination of the current situation, recognition of the potentials in agricultural areas and natural resources as the main origin of the country's native species, and a correct understanding of the limitations and challenges along with the development. It is the science of its processing and consumption. This study was also conducted in order to know the medicinal, phytochemical, economic, etc. potentials of Moringa plant. t is the science of its processing and consumption. This study was also conducted in order to know the medicinal, phytochemical, economic, etc. potentials of Moringa plant.t is the science of its processing and consumption. This study was also conducted in order to know the medicinal, phytochemical, economic, etc. potentials of Moringa plant

منابع و مأخذ:

1.Bigi A. Production and processing of medicinal plants. Astan Quds Razavi Pub-lications, first volume, pages 1383;73-190.

2.Salehi M. H, Wamin G. Global clinics, medicinal plants and herbal medicines. Razi Magazine.1980; 3: 33-38.

3.Nurzaei A. Carla, the most effective pla-nt in the treatment of diabetes. Advice Publications. 1388.

4.Heneka N. Chamomilla recutita I. Austr-alin. plant physiology. 1993; 5:33-39.

5.Donga JJ, Surani VS, Sailor GU, Cha-uhan SP, Seth AK. A systemic review on natural medicine used for therapy of dia-betes mellitus of smeindianmedicialolants. An international Journal of Pharmaceutical Sciences.2011; 2:7906-7908.

  1. Zargari A. Methodology of plants (cont-inuous petal plants). 1342: 201.
    2.

7.Assubaie NF and El-Garawany MM. Evaluation of Some Important Chemical Constituents of Momordica charantia Jour-nal of Biological Sciences, 2004; 4 (5): 628-630.

8-Taylor L. Technical Data Report For Bitter Melon (momordica char antia). Her-bal Secrets of the Rainforest.2nd edition. Sage Press.Austin. 2002.

9.Hajizadeh MR, Mahmoudi M, Mirzaei MH, Mohi-Dini A, Sayadi AR. Beneficial effects of the plant (MC) momordica cha-rantia on some biochemical parameters in laboratory mice, Medical Journal of the Faculty of Medical Sciences.2016, 4(4).

10.Rodriguez DB, Raymundo LC, Lee TC, Simpson KL and Chichester CO. Carot-enoid pigment changes in ripening Momo-rdica charantia fruits. Ann. Bot-London. 1976; 40:615-624.

11.Morton JF. The balsam pear- an edible, medicinal and toxic plant.Econ. Bot, 2008; 21:57-68.

12.Yen GC, and Hwang LS. Lycopene from the seeds of bitter melon (Momordica charantia) as a potential red food colorant. II. Storage stability, preparation of pow-dered iycopene and food applications. J. Chin. Agric. Chem. Soc, 1985; 23: 151-161.

  1. Alamgir Z, Chowdhury M. Ibrahim Hossain Md, Hossain S, et al. Antidiabetic Effects oiMomordica Chamntia (Karela) in Male long Evans Rat. Research Biological. 2012;3(3):175-180
    2.
  2. Ekramul Haque M, Badrul Alam M and Sarowar Hossain M. The Efficacy of Cuc-urbitane Type Triterpenoids, Glycosides and Phenolic Compounds Isolated From Momordica Charantia Ijpsr. 2011; 2(5): 1135-1146.
    3.

15.Harinantenaina L, Tanaka M, Takaoka S, da M, Mogami O, Uchida M, AsakawaY. Momordica charantia constituents and anti-diabetic screening of the isolated major compounds. Chem Pharm Butt (Tokyo). 2006; 54:1017-1021.

  1. Raman A and Lau C. Anti-diabetic properties and pbytochemistry Momordica charantia L. (Curcurbitaceae). Phytome-dicine. 1996; 2:349-662.
    2.

17.Oishi Y, Sakamoto T, Udagawa H, dagawa H, et al. Inhibition of increases in blood glucose and serum neutral fat by Momordica charantia saponin fraction. Biosci Biochem, 2007; 71:735-740.

18.Morton JF. The balsam pear- an edible, medicinal and toxic plant. Econ. Bot. 2008; 21:57-68.

  1. Zargari A. Medicinal Plants, Tehran University Press.1375; 3.
    2.

20.Maria, Collazo-Clavell, Ed.M.Mayo Cl-inic the essential diabetes book. New York: Time Ine. Home Entertainment Books. 2009; 7-133.

21.Khanna P, Jain SC, Panagariya A and Dixit VP. Hypoglycemic activity of polyp-eptide-p from a plant source. J. Nat. Prod.1981; 44'648-655.

  1. Cunnick J, Takemoto D. Bitter melon (Momordica charantia) Naturopath Med. 1993; 4:16-21.
    2.
  2. Krawinkel MB and Reding GB. Bitter gourd (Momordica Charantid): A dietary ;approach to hyperglycemia". Nutr. Rev. 2006; 64 (7 Pt 1):7-331.
    3.
  3. Rodriguez DB, Raymundo LC, Lee TC, Simpson KL and Chichester CO. Car-otenoid pigment changes in ripening Mom-ordica charantia fruits. Ann. Bot-Lond-on.1976; 40:615-624.
    4.

25.Harinantenaina L, Tanaka M, Takaoka S, da M, Mogami O, Uchida M and Asakawa Y. Momordica charantia constit-uents and antidiabetic screening of the isolated major compounds. Chem Pharm Butt (Tokyo). 2006; 54:1017-1021.

26.Krawinkel MB and Reding GB. Bitter gourd (Momordica Charantid): A dietary ;approach to hyperglycemia". Nutr. Rev. 2006; 64 (7 Pt 1):7-331.

27.Yen GC and Hwang LS. Lycopene from the seeds of npe bitter melon (Mom-ordica charantia) as a potential red food colorant. II. Storage stability, preparation of pow-dered iycopene and food applic-ations. J. Chin. Agric. Chem. Soc.1985; 23: 151-161.

28.Sarkar S, Pranava M. Demonstration of the hypoglycemic action of Momordica charantia in a validated animal model of diabetes. Pharmacol Res. 1996; 33:1-4.

29-Yibchok-nun S, Adisakwattana S and Yao CY. Slow Acting protein extract from fruit pulp of Momordica charantia with insulin secretagogue and in sulinomimetic activities. Biol Pharm Bull. 2006; 29:1126-1131.

30-Welihinda J, Arvidson G and Gylfe E. The insulinreleasing activity of the tropical plant Momordica chara.Acta. Bio. Med. Germ. 1982;41:1229-1240.

  1. Ahmed I, Adghate E and Sharma AK. Effects of momordica charantia fruit juice on islet morphologyin the pancreas of the streptozotocin-diabetic rat Diabetes Res Clin Pract.1998; 40:145-151.
    2.

32-Ng Tb, Wong CM, Li ww, Yeung HM. Isolation and characterization of agalactose binding lectin with insulinomimetic acti-vities. From the seeds of the  Bitter Gourd Momordica Charantia. Int Jpept Proten Res. 1986; 28(2):163-172.

  1. Alamgir Z, Chowdhury M. Ibrahim Hossain, Md. Sabir Hossain. Sohel Ahm-eti, Tanzila Afrin and Nurul Karim. Antidiabetic Effects oiMomordica Cham-ntia (Karela) in Male long Evans Rat. Research Biological. 2012; 3(3): 175-180.
    2.

34.Kandra A, Ali Mehdi A, Rizvi V, Sineq Rak, Ahmad S, Mishra L. The effect of blood sugar-lowering plant agents on anti-oxidant enzymes and metal ions in strepto-zotocin-treated diabetic rats, Iranian Jou-rnal of Diabetes and Lipid. 2013; 4(1): 19-26.

35.Vesely DL, Graves WR, Lo TM, et al. Isolation of a guanylate cyclase inhibitor from the balsam pear(momordica charantia abreviata).Biochys Res Commun. 1978; 77:1294-1299.

36-Claflin AJ, Vesely DL, Hudson JL, et al. Inhibition of growth and guanylate cyclase activity of an extract of the balsam pear (momordica charantia abreviata).Proc Natl Acad Sci USA.1978;75:989-993.

37.Manabe M, Takenaka R, Nakasa T, Okinaka O. Induction of anti-inflammatory responses by dietary Momordica charantia L. (bitter gourd). Biosci Biotecknol Biocb-em. 2003; 67:2512-2517.

38.Takemoto DJ, Dunford C, Vaughn D, Kramer KJ, Smith A and Powell RG; GuanylateSreeDattha Institute of Pharma-cy, Sheriguda, Ibrahimpatnam, Greater Hyderabad. PNAS .2000;97(8):4221-4226.

  1. Kobori M, Kameyama MO, Akimoto Y, Yukizaki C and Yoshida M:-Eleostearic acid and its Dihydroxy Derivative are Major Apoptosis-inducing Components of Bitter Gourd. Journal of Agricultural and Food Chemistry, 2008; 56:10515-10520.
    2.
  2. Güneş H, Alper M, Çelikoğlu N. Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucu-rbitaceae) on human cancer cell lines. Tropical Journal of Pharmaceutical Rese-arch. 2019; 18 (10): 2057-2065.
    3.

41.Kaur M, Deep G, Jain AK, Raina K, Agarwal C, Wempe MF, Agarwal R .Bitter melon juice activates cellular energy sen-sor AMP-activated protein kinase causing apoptotic death of human pancreatic carc-inoma cell. Carcinogenesis. 2013; 34: 1585–1592.

42.Ray RB, Raychoudhuri A, Steele R, Nerurkar P. Bitter melon (Momordica cha-rantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apopto-sis. Cancer Res. 2010;70:1925–1931

  1. Kwatra D, Subramaniam D, Ramamoo-rthy P, Standing D, Moran E, Velayutham R, Mitra A, Umar S, Anant SM. ethanolic extracts of bitter melon inhibit colon can-cer stem cells by affecting energy hom-eostasis and autophagy. Evid Based Comp-lement Alternat Med. 2013:702869.
    2.

44.Weng JR, Bai LY, Chiu CF, Hu JL, Chiu SJ, Wu CY .Cucurbitane triterpenoid from Momordica charantia induces apopt-osis and autophagy in breast cancer cells, in part, through peroxisome proliferator-activated receptor gamma activation. Evid. Based Complement Alternat. Med. 2013: 935675.

45.Qian S, Sun L, Li J, Wu J, Hu G, Han Y, Yu K, Zhang S. MAP30 inhibits autophagy through enhancing acetyltrans-ferase p300 and induces apoptosis in acute myeloid leukemia cells. Oncol. Rep. 2016; 35:3705–3713. doi: 10.3892/or.2016.4705. [PubM-ed] [Cr-ossRef] [Google Scholar]

46.Soundararajan R, Prabha P, Rai U, Dixit A. Antileukemic Potential of Momo-rdica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells. Evid.-Based Com-plement. Altern. Med. 2012; 2012:732404. doi: 10.1155/2012/732404. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

 

47.Kobori M, Ohnishi-Kameyama M, Aki-moto Y, Yukizaki C, Yoshida M. Alpha-eleostearic acid and its dihydroxy derive-ative are major apoptosis-inducing compo-nents of bitter gourd. J. Agric. Food Chem. 2008; 56:10515–10520.

doi: 10.1021/jf8020877. [PubMed] [Cro-ssRef] [Google Scholar]

48.Kai H, Akamatsu E, Torii E, Kodama H, Yukizaki C, Sakakibara Y, Suiko M, Mor -ishita K, Kataoka H, Matsuno K. Inhibition of proliferation by agricultural plant ext-racts in seven human adult T-cell leukaemia (ATL)-related cell lines. J. Nat. Med. 2011; 65:651–655.

doi: 10.1007/s11418-011-0510-5. [PubMe-d] [CrossRef] [Google Scholar]

49.Jilka C, Strifler B, Fortner GW, Hays EF, Takemoto DJ. In vivo antitumor acti-vity of the bitter melon (Momordica cha-rantia). Cancer Res. 1983; 43:5151–5155.

50.Jiang Y, Miao J, Wang D, Zhou J, Liu B, Jiao F, Liang J, Wang Y, Fan C, Zhang Q. MAP30 promotes apoptosis of U251 and U87 cells by suppressing the LGR5 and Wnt/beta-catenin signaling pathway, and enhancing Smac expression. Oncol. Lett. 2018;15:5833–5840.

doi: 10.3892/ol.2018.8073. [PMC free art-icle] [PubMed] [CrossRef] [Google Scho-lar]

51.Manoharan G, Jaiswal SR, Singh J. Effect of alpha, beta momorcharin on viability, caspase activity, cytochrome c release and on cytosolic calcium levels in different cancer cell lines. Mol. Cell. Biochem. 2014;388:233–240.

 doi: 10.1007/s11010-013-1914-1. [PubM-ed] [CrossRef] [Google Scholar]

  1. Wang X, Sun W, Cao J, Qu H, Bi X, Zhao Y. Structures of new triterpenoids and cytotoxicity activities of the isolated major compounds from the fruit of Momo-rdica charantia L. J. Agric. Food Ch-em. 2012;60:3927–3933. doi: 10.1021/jf204 208y. [PubMed][CrossRef] [Google Scho-lar]
    2.

53.Hsiao PC, Liaw CC, Hwang SY, Cheng HL, Zhang LJ, Shen CC, Hsu FL, Kuo YH. Antiproliferative and hypoglycemic cucu-rbittane-type glycosides from the fruits of Momordica charantia. J. Agric. Food Ch-em. 2013; 61: 2979–2986.

 doi: 10.1021/jf3041116. [PubMed] [Cross-Ref] [Google Scholar]

54.Ray RB, Raychoudhuri A, Steele R, Nerurkar P. Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apop-tosis. Cancer Res. 2010; 70: 1925–1931. doi:10.1158/0008-5472.CAN-09-3438. [PubMed][CrossRef][Google Scholar]

  1. Muhammad N, Steele R, Isbell TS, Philips N, Ray RB. Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell dea-th. Oncotarget. 2017;8:66226–66236. doi: 10.1 8632/oncotarget.19887. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Shim SH, Sur S, Steele R, Albert CJ, Huang C, Ford DA, Ray RB. Disrupting cholesterol esterification by bitter melon suppresses triple-negative breast cancer cell growth. Mol. Carcinog. 2018; 57: 1599–1607. doi: 10.1002/mc.22882. [PubMed] [CrossRef] [Google Scholar]
    3.

57.Bai LY, Chiu CF, Chu PC, Lin WY, Chiu SJ, Weng JR. A triterpenoid from wild bitter gourd inhibits breast cancer cells. Sci. Rep. 2016;6:22419. doi: 10. 1038/sre-p22419. [PMC free article] [Pub-Med] [CrossRef] [Google Scholar]

  1. Weng JR, Bai LY, Chiu CF, Hu JL, Chiu SJ, Wu CY. Cucurbitane Triterpenoid from Momordica charantia Induces Apopt-osis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor gamma Activation. Evid.-Based Complement. Altern. Med. 2013; 2013: 935675. doi: 10.1155/ 2013/ 935675.[PMC free article] [PubMed] [Cro-ssRef] [Google Scholar]
    2.
  2. Grossmann ME, Mizuno NK, Dammen ML, Schuster T, Ray A, Cleary MP. Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. Cancer Prev. Res. 2009; 2:879–886. doi: 10.1158/1940-6207. CAPR-09-0088.[PubMed][CrossRef][Go-ogle Scholar]
    3.
  3. Nagasawa H, Watanabe K, Inatomi H. Effects of bitter melon (Momordica char-antia L.) or ginger rhizome (Zingiber offifinale rosc) on spontaneous mammary tumorigenesis in SHN mice. Am. J. Chin. Med. 2002; 30:195–205. doi: 10.1142/ S0192415X02000302. [PubMed] [Cross-Ref] [Google Scholar]
    4.

61.Konishi T, Satsu H, Hatsugai Y, Aiza-wa K, Inakuma T, Nagata S, Sakuda SH, Nagasawa H, Shimizu M. Inhibitory effect of a bitter melon extract on the P-glyc-oprotein activity in intestinal Caco-2 cells. Br. J. Pharmacol. 2004; 143: 379–387. doi: 10.1038/sj.bjp.0705804. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

  1. Yasui Y, Hosokawa M, Sahara T, Suzuki R, Ohgiya S, Kohno H, Tanaka T, Miyashita K. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells. Prostaglandins Leukot. Essent. Fat. Acids. 2005; 73: 113–119. doi: 10.1016/j.plefa.2005.04.013. [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Chipps ES, Jayini R, Ando S, Protzman AD, Muhi MZ, Mottaleb MA, Malkawi A, Islam MR. Cytotoxicity ana-lysis of active components in bitter melon (Momordica charantia) seed extracts using human embryonic kidney and colon tumor cells. Nat. Prod. Commun.2012; 7: 1203–1208.
    3.

64-Sur S, Nakanishi H, Flaveny C, Ippolito JE, McHowat J, Ford DA, Ray RB. Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract. Cell Commun. Signal. CCS. 2019; 17: 131. doi: 10.1186/ s12964-019-0447-y. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

  1. Sur S, Steele R, Aurora R, Varvares M, Schwetye KE, Ray RB. Bitter Melon Prevents the Development of 4-NQO-Induced Oral Squamous Cell Carcinoma in an Immunocompetent Mouse Model by Modulating Immune Signaling. Cancer Prev. Res. 2018; 11: 191–202.
    2.

doi: 10.1158/1940-6207.CAPR-17-0237. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

  1. Bhattacharya S, Muhammad N, Steele R, Kornbluth J, Ray RB. Bitter Melon Enhances Natural Killer-Mediated Toxicity against Head and Neck Cancer Cells. Cancer Prev. Res. 2017; 10: 337–344. doi: 10.1158/1940-6207.CAPR-17-0046. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Bhattacharya S, Muhammad N, Steele R, Peng G, Ray RB. Immunomodulatory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth. Oncotarget. 2016; 7: 33202–33209. doi: 10.18632/oncotarget.8898. [PMC free article] [PubMed] [CrossRef] [Google Sch-olar]
    3.
  3. Rajamoorthi A, Shrivastava S, Steele R, Nerurkar P, Gonzalez JG, Crawford S, Varvares M, Ray RB. Bitter melon reduces head and neck squamous cell carcinoma growth by targeting c-Met signaling. PLoS ONE. 2013;8:e78006.
    4.

doi: 10.1371/journal.pone.0078006

69.Brennan VC, Wang CM, Yang WH. Bitter melon (Momordica charantia) extr-act suppresses adrenocortical cancer cell proliferation through modulation of the apoptotic pathway, steroidogenesis, and insulin-like growth factor type 1 recept-or/RAC-alpha serine/threonine-protein kin-ase signaling. J. Med. Food. 2012; 15: 325–334. doi: 10.1089/jmf.2011.0158. 

  1. Yue J, Sun Y, Xu J, Cao J, Chen G, Zhang H, Zhang X, Zhao Y. Cucurbitane triterpenoids from the fruit of Momordica charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities. Phytochem-istry. 2019; 157: 21–27.
    2.
  2. Fang EF, Zhang CZ, Wong JH, Shen JY, Li CH, Ng TB. The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo. Cancer Lett. 2012; 324:66–74. doi: 10.1016/j.canlet. 2012.05. 005. [PubMed] [CrossRef] [Goo-gle Sch-olar]
    3.
  3. Ali MM, Borai IH, Ghanem HM, Abdel-Halim AH, Mousa FM. The prophylactic and therapeutic effects of Momordica charantia methanol extract through controlling different hallmarks of the hepatocarcinogenesis. Biomed. Pharma cother.2018; 98: 491–498.
    4.
  4. Nerurkar PV, Pearson L, Efird JT, Adeli K, Theriault AG, Nerurkar VR. Micr-osomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells. J. Nutr. 2005; 135: 702–706. doi: 10.10 93/jn/135.4.702.
    5.

74.Thiagarajan S, Arapoc DJ, Husna Shafie N, Keong YY, Bahari H, Adam Z, Ei T. Momordica charantia (Indian and Chinese Bitter Melon) Extracts Inducing Apoptosis in Human Lung Cancer Cell Line A549 via ROS-Mediated Mitochodria Injury. Evid.-Based Complement. Altern. Med. 2019; 2821597.

doi: 10.1155/2019/2821597. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

  1. Fan X, He L, Meng Y, Li G, Li L, Meng Y. Alpha-MMC and MAP30, two ribo-some-inactivating proteins extracted from Momordica charantia, induce cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Mol. Med. Rep. 2015; 11: 3553–3558. doi: 10.3892/mmr.2015.3176. [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Hsu HY, Lin JH, Li CJ, Tsang SF, Tsai CH, Chyuan JH, Chiu SJ, Chuang SE. Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells. Evid.-Based Complement. Altern. Med. 2012; 819632.
    3.

77.Pitchakarn P, Umsumarng S, Mapoung S, Ting P, Temviriyanukul P, Punfa W, Pompimon W, Limtrakul P. Kuguacin J isolated from bitter melon leaves modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells. J. Nat. Med. 2017; 71:693–702. doi: 10.1007/s11418-017-1099-0. [PubMed] [CrossRef] [Google Scholar]

  1. Yung MM, Ross FA, Hardie DG, Leung TH, Zhan J, Ngan HY, Chan DW. Bitter Melon (Momordica charantia) Ext-ract Inhibits Tumorigenicity and Overco mes Cisplatin-Resistance in Ovarian Can cer Cells Through Targeting AMPK Signa-ling Cascade. Integr. Cancer Ther. 2016; 15: 376–389.
    2.

doi: 10.1177/1534735415611747.

79.Kaur M, Deep G, Jain AK, Raina K, Agarwal C, Wempe MF, Agarwal R. Bitter melon juice activates cellular energy sen-sor AMP-activated protein kinase causing apoptotic death of human pancreatic carci-noma cells. Carcinogenesis. 2013; 34: 1585-1592.

doi: 10.1093/carcin/bgt081. [PMC free art-icle][PubMed][CrossRef][Google Scholar]

  1. Somasagara RR, Deep G, Shrotriya S, Patel M, Agarwal C, Agarwal R. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in panc-reatic cancer cells. Int. J. Oncol. 2015;46: 1849–1857. doi: 10.3892/ijo.2015.2885. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Dhar D, Deep G, Kumar S, Wempe MF, Raina K, Agarwal C, Agarwal R. Bitter melon juice exerts its efficacy agai-nst pancreatic cancer via targeting both bulk and cancer stem cells. Mol. Carci-nog. 2018; 57: 1166-1180. doi: 10.1002/ mc.22 833. [PMC free article] [PubMed] [Cro-ssRef] [Google Scholar]
    3.
  3. Dhar D, Raina K, Kant R, Wempe MF, Serkova NJ, Agarwal C, Agarwal R. Bitter melon juice-intake modulates glucose met-abolism and lactate efflux in tumors in its efficacy against pancreatic cancer. Carcin-ogenesis. 2019; 40: 1164–1176. doi: 10. 1093/carcin/bgz114. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
    4.

83.Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, Limtrakul P, Shirai T. Kuguacin J, a triterpeniod from Momordica charantia leaf, modulates the progression of andro-gen-independent human prostate cancer cell line, PC3. Food Chem. Toxicol. 2012; 50: 840–847. doi: 10.1016/j.fct.2012.01. 009. [PubMed] [CrossRef] [Google Scho-lar]

  1. Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, Limtrakul P, Shirai T. Momordica char-antia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci. 2010; 101: 2234–2240. doi: 10.1111/j.1349-7006.2010.01669.x. [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB. Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model. Cancer Prev. Res. 2011; 4: 2122–2130.
    3.

doi: 10.1158/1940-6207. CAPR-11-0376. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

  1. Xiong SD, Yu K, Liu XH, Yin LH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, et al. Ribosome-ina-ctivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in prema-lignant and malignant prostate cancer cells. Int. J. Cancer. 2009; 125: 774–782. doi: 10.1002/ijc.24325. [PMC free article] [Pu-bMed] [CrossRef] [Google Scholar]
    2.

87.Agrawal RC, Beohar T. Chemopreve ntive and anticarcinogenic effects of Mom-ordica charantia extract. Asian Pac. J. Cancer Prev. 2010; 11: 371–375. [Pub-Med] [Google Scholar]

  1. Akihisa T, Higo N, Tokuda H, Ukiya M, Akazawa H, Tochigi Y, Kimura Y, Suzuki T, Nishino H. Cucurbitane-type triterp-enoids from the fruits of Momordica charantia and their cancer chemoprevent-ive effects. J. Nat. Prod. 2007; 70: 1233–1239. doi: 10.1021/np068075p. [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Ganguly C, De S, Das S. Prevention of carcinogen-induced mouse skin papilloma by whole fruit aqueous extract of Momor-dica charantia. Eur. J. Cancer prevention J. Eur. Cancer Prev. Organ. 2000; 9: 283-288.
    3.

doi: 10.1097/00008469-200008000-00009. [PubMed] [CrossRef] [Google Scholar]

90.Deep G, Dasgupta T, Rao AR, Kale RK. Cancer preventive potential of Momo-rdica charantia L. against benzo(a)pyrene ind-uced fore-stomach tumourigenesis in mu-rine model system. Indian J. Exp. Biol. 2004; 42: 319–322. [PubMed] [Google Scholar]

  1. Li Y, Yin L, Zheng L, Xu L, Xu Y, Zhao Y, Qi Y, Yao J, Han X, Liu K, et al. Application of high-speed counter-current chromatography coupled with a reverse micelle solvent system to separate three proteins from Momordica charantia. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2012; 895–896: 77–82. doi: 10.1016/j.jchromb.2012.03.017. [PubMed] [CrossRef] [Google Scholar]
    2.
  2. Li CJ, Tsang SF, Tsai CH, Tsai HY, Chyuan JH, Hsu HY. Momordica charantia Extract Induces Apoptosis in Human Can-cer Cells through Caspase-and Mitoch-ondria-Dependent Pathways. Evid.-Based Complement. Altern. Med. 2012; 261971. doi: 10.1155/2012/261971. [PMC free arti-cle] [PubMed] [CrossRef] [Google Scho-lar]
    3.
  3. Cunnick J, Takemoto D. Bitter melon (Momordica charantia) Naturopath Med, 1993; 4: 16-21.
    4.

94.Zhang QC.Preliminiary report on the use of Momordica charantia extract by HIV patients.J Naturopath Med. 1992; 3: 65-69.

95.Saeed S and Tariq P. Antibacterial activities of Mentha piperita, Pisum sati-viirn and Momordica charaniia. Pak J. Bot. 2005; 37:997-1001.

  1. Saravani K, Khajeh H, Soltani B, Abk-ho J, Javadian F. Investigating the antim-icrobial activity of the ethanolic extract of the carla plant (Momordica Charantia) on Acinetobacter baumannii bacteria isolated from clinical samples. Journal of Zabul Medical School. 2017; 1(1), 21-26.
    2.

97.Saeidian S, Eslami M, Dashipoor A. Antibacterial Effect of Alcoholic and Aqu-eous Extract of Carla on Escherichia coli and Staphylococcus aureus. psj. 2019; 17 (4):15-24.

  1. Masithoh DA, Kusdarwati R, Handij-atno D. Antibacterial activity of bitter go-urd (Momordica charantia l.) leaf extract against Aeromonas hydrophila. Earth and Environmental Science. 2019; 236.
    2.
  2. M. Costa JG, M. M. Nascimento E, R. Campos A and F. G. Rodrigues F. Anti-bacterial activity of Momordica charantia (Curcubitaceae) extracts and fractions. Jou-rnal of Basic and Clinical Pharmacy. 2010.
    3.
  3. de Lucena Filho JHS, de Freitas Lima R, de Medeiros ACD, Pereira JV, Gran-ville-Garcia AF, de Brito Costa EMM. Antimicrobial Potential of Momordica cha-rantia L. against Multiresistant Standard Species and Clinical Isolates. J Contemp Dent Pract. 2015; 16(11): 854-858.
    4.

101.Zaheer Ahmed and Agha Asad Noor. Antibacterial activity of Momordica char-antia L. and Citrus limon L. on gram positive and gram negative bacteria. Pure Appl. Biol. 2020; 9(1): 207-218.

102.Grover JK and Yadav SP. Pharmac-ological actions and potential uses of Mo-mordica charaniia. a review. J. Ethnoph-armacol. 2004; 93:123-132.

103.Leung SO, Yeung HW and Leung KN:the Immunosunosuppressive Activities of two Abortifacifacient Proteins isolated from the seeds of Bitter MelonMomordica Charantia). Immunopharmacology. 1987; 13: 159-171.

104-Cunnick JE, Sakamoto K, Chapes SK, Fortner GW and Takemoto DJ: Induction of tumor cytotoxic immune cells using a protein from the bitter melon (Momordica charantia). Cellular Immunology. 1990; 126: 278-289.

105.Wang HX and Ng TB;Studies on the anti-mitogenic,anti-phage and Hypotensive effects of several ribosome inactivating proteins. Comparative Biochemistry and Physiology C-pharmacology Toxicology b. 2001; 128: 359-366.

106-Hayashi K, Takehisa T, Hamato N, Takano R, Hara S, Miyata T and Kato of several H:inhibition of serine proteases of the blood coagulation system by squash family protease inhibitors. Journal of Bioc-hemistry (Tokyo). 1994; 116: 1013-1018.

107.Gurbuz I, Akyuz C, Yesilada E and Sener B:Anti-Ulcerogenic effect of Mom-ordica charantia L. fruits on various Ulcer models in rats. Journal of Ethnopharma-cology. 2000; 7: 77-82.

108-Matsuda H, Li Y and Yoshikawa M: Roles of Capsaicin-sensitive sensory nerv-es, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic an oleanolic acid oligogly-coside, on ethanol-induced gastric mucosal lesions in rats.Life Science. 1999; 65: PL27-PL32.

109.Song J, Kwon O, Chen S, Daruwala R, Eck P, Park JB, et al. Flavonoid inhibition of sodium-dependent vitamin c transport-ters for vitamin c and glucose. J Biol Chem. 2002; 227(18):60-15252.

110-Chaudhari BP, Chaware VJ, joshi YR and Biyani KR:Hepatoprotective activity of hydroalcoholic extract of Momordica Charantia Linn.Leaves against Carbon tetr-achloride induced Hepatopathy in Rats. International Journal of Chem Tech Rese-arch. 2009; 1(2): 355-358.

  1. Dhar P, Chattopadhyay K, Bhatlach-aryya D, Roychoudhury A, Biswas A, and Ghosh S. Antioxidative effect of conjug-ated linolenic acid in diabetic and non-diabetic blood an in vilo study. J.OIeoSci. 2007; 56: 19-24.
    2.
  2. Aljohi A, Matou-Nasri S and Ahmed N. Antiglycation and Antioxidant Properties of Momordica charantia. PLoS One.2016; 11(8): e0159985.
    3.
  3. Sathishsekar D, Subramanian S. Anti-oxidant properties of Momordica Charantia (bitter gourd) seeds on Streptozotocin ind-uced diabetic rats. Asia Pac J Clin Nutr. 2005; 14(2): 8-153.
    4.

114.Wu SJ, Lean-Teik Ng. Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviate Ser.) in Taiwan. LWT - Food Science and Technology. 2008; 41 (2): 323-330.

  1. Chen Q, Chan LLY, Li ETS. Bitter melon (Momordica charaniia) reduces adi-posity, lowers serum insulin and norm-alizes glucose tolerance in rats fed a high fat diet. J. Nutr. 2003; 133 1088-1093.
    2.
  2. Maria, Collazo-Clavell, Ed.M.Mayo Clinic:The essential diabetes book.New York:Time Ine.Home Enterainment Books. 2009;7-133.
    3.
  3. Mensier PH, Dictionnaire dey builey vegetales.Lechevalier Paris.1957; 78.
    4.
  4. Abascal K, Yarnell E.Using bitter melon to treat Diabetes. Altern. Com plement Ther.Med. 2005;11:179-184.
    5.
  5. Grover JK and Yadav SP. Pharm-acological actions and potential uses of Momordica charaniia. a review. J. Ethno-pharmacol. 2004; 93:123-132.
    6.
  6. Yesilada E, Gurbuz I and Shibata H. Screening of Turkish antiulcerogenic folk remedies for ar\t\-Helicobacter pylori ac vity. Journal of Ethnopharmacology. 1999; 66: 289-293.
    7.
  7. Kumar DS, Sharathnath JV, Yogesw-aran P, Harani A, Sudhakar K, Sudha P and Banji D:A medicinal potency of Mom-ordica charantia. Lnternational journal of Pharmaceutical Science Review and Rese-arch. 2010; 1 (2): 95-100.
    8.
  8. Head KA. Herbal remedies that may help control blood sugar. In: Bratman S, Kroll D, eds. The NaturalPharmacist, Everything You Need to Know About Diabetes. New York, NY:Prima Publicat-ions, Inc. 1999;51-53.
    9.
  9. Biglou Iliad A., Kermanizadeh P. Studying the performance of water extracts of bitter cucumber (Charantia, Momordi-ca), Gymnemasylvestre and Jumbo (Euge-nia jumbolana) in lowering blood sugar under in vitro conditions, comparative pa-thobiology, scientific-research. 1390;8(3): 555-560.
    10.

124. Alamgir Z. Chowdhury M, Ibrahim Hossain Md. Sabir Hossain. Sohel Ahmeti, Tanzila Afrin and Nurul Karim. Antid-iabetic Effects oil Momordica Chamntia (Karela) in Male long Evans Rat. Research Biological. 2012; 3(3): 175-180

_||_

مقالات مرتبط

حقوق این وب‌سایت متعلق به سامانه مدیریت نشریات دانشگاه آزاد اسلامی است.
حق نشر © 1403-1400

صفحه اصلی| عضویت/ ورود| درباره سند| تماس با ما|
[English] [العربية] [en] [ar]