Simultaneous optimization of extraction of bioactive compounds and antioxidant activity of Ammi visnaga (L.) Lam aerial parts using response surface methodology
محورهای موضوعی : Phytochemistry: Isolation, Purification, CharacterizationZineb El Jabboury 1 , Smail Aazza 2 , Driss Ousaaid 3 , Oumaima Chater 4 , Uroš Gašić 5 , Peđa Janaćković 6 , Zora Dajic Stevanovic 7 , Stefan Kolašinac 8 , Meryem Benjelloun 9 , Lahsen El Ghadraoui 10
1 - Laboratory of Functional Ecology and Environmental Engineering, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University - Fez, Morocco.
2 - National Agency of Medicinal and Aromatic Plants (NAMAP/ANPMA)-Taounate, Morocco
3 - Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez P.O. Box 3000, Morocco
4 - Laboratory of Functional Ecology and Environmental Engineering, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University - Fez, Morocco
5 - Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia
6 - University of Belgrade, Faculty of Biology, Studentski trg 16, 11000 Belgrade, Serbia
7 - University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11060 Belgrade, Serbia
8 - University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11060 Belgrade, Serbia
9 - Laboratory of Functional Ecology and Environmental Engineering, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University - Fez, Morocco
10 - Laboratory of Functional Ecology and Environmental Engineering, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University - Fez, Morocco
کلید واژه: Ammi visnaga (L.) Lam, Antioxidant activity, Bioactive compounds, Response surface methodology, Total phenolic content,
چکیده مقاله :
In this report, different extracts from the aerial parts of Ammi visnaga (L.), e.g., flowers, leaves, and stems were prepared using water, methanol, and ethanol. To optimize the extraction process, the design of mixtures was carried out using different extracting solvents and their combinations. The special cubic model explained the variance of the TPC and the antioxidant activity of the extracts at a level of R2 > 95%. In general, the analysis of the model-derived response surfaces revealed that in binary mixtures (50% ethanol + 50% methanol), the yielded values of phenolic compounds and the antioxidant activity increase with the water proportion of different prepared mixtures. The ability of the quaternary mixture to extract the phenolic compounds was also positively and significantly influenced by the water content, creating a mild polar medium for the extraction of phenolic compounds. The phenolic profile of different extracts under study revealed the presence of a cocktail of active ingredients, including chlorogenic acid, caffeic acid, rutin, p-coumaric acid, etc. especially the flower extract of A. visnaga (L.).
In this report, different extracts from the aerial parts of Ammi visnaga (L.), e.g., flowers, leaves, and stems were prepared using water, methanol, and ethanol. To optimize the extraction process, the design of mixtures was carried out using different extracting solvents and their combinations. The special cubic model explained the variance of the TPC and the antioxidant activity of the extracts at a level of R2 > 95%. In general, the analysis of the model-derived response surfaces revealed that in binary mixtures (50% ethanol + 50% methanol), the yielded values of phenolic compounds and the antioxidant activity increase with the water proportion of different prepared mixtures. The ability of the quaternary mixture to extract the phenolic compounds was also positively and significantly influenced by the water content, creating a mild polar medium for the extraction of phenolic compounds. The phenolic profile of different extracts under study revealed the presence of a cocktail of active ingredients, including chlorogenic acid, caffeic acid, rutin, p-coumaric acid, etc. especially the flower extract of A. visnaga (L.).
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