List of Articles Platelet

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  1 - A review of platelet-rich fibrin and its application in the treatment of diseases
  Naser Kalhorqom Mohsen Sheykhhasan Fatemeh Nasiri Azar Sheikholeslami
  Two decades have passed since platelet rich fibrin (PRF) was first introduced. The primary objective was to develop a therapy where platelet concentrates could be introduced into wounds by effectively utilizing the body’s natural healing capacity. This was achieve More

  Two decades have passed since platelet rich fibrin (PRF) was first introduced. The primary objective was to develop a therapy where platelet concentrates could be introduced into wounds by effectively utilizing the body’s natural healing capacity. This was achieved by collecting growth factors derived from blood in a natural way. Platelet rich plasma (PRP) and platelet rich growth factor (PRGF) had been commercialized, yet both contained secondary byproducts that were both unnatural and known inhibitors of wound healing. By removing these anti-coagulants and modifying centrifugation protocols, PRF was introduced some years later with the potential to markedly impact many fields of medicine including dentistry. Many aspects important for tissue regeneration have since been revealed including the important role of fibrin as well as the preferential release of growth factors over longer periods of time from PRF. Furthermore, by introducing a new set of cells into platelet concentrates, a marked impact on tissue regeneration and wound healing was observed. Further modifications to centrifugation speed and time have additionally improved PRF into a concept. Investigators began to modify surgical techniques to favorably treat patients with PRF with improved clinical outcomes. In this first chapter, we highlight the discovery of PRF and the studies leading to its first use in regenerative medicine. We focus specifically on its properties for wound healing and how its presented advantages over previous versions of platelet concentrates have favorably enhanced the regenerative potential of platelet concentrates in dentistry. Manuscript profile
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  2 - In vivo evaluation of Polygonum bistorta extract effect on blood coagulation factors
  Marzieh Moiedie Jafar Vatandoost Toktam Hajjar Behnam Mahdavi
  10.30495/tpr.2023.1976011.1312
  Polygonum bistorta contains phytochemical compounds that can affect coagulation. It is used as hemorrhoid for bleeding control in traditional medicine. For its in vivo evaluation, 35 mice were randomly divided into 5 groups (n = 7) as well as the negative and positive c More

  Polygonum bistorta contains phytochemical compounds that can affect coagulation. It is used as hemorrhoid for bleeding control in traditional medicine. For its in vivo evaluation, 35 mice were randomly divided into 5 groups (n = 7) as well as the negative and positive control. On the 13th day of treatment, blood samples were collected for bleeding time (BT), clotting time (CT) and the number of platelets and on the 14th day, for prothrombin time (PT), activated partial thromboplastin time (aPTT). The results were shown although P. bistorta extract had a significant reducing effect on all coagulation tests in a dose-dependent manner, the greatest reduction in coagulation time (16.5 times) in the CT test and the best significant dosage is 1000 mg/kg/day shows that the P. bistorta extract has a greater effect on the common pathway than intrinsic and extrinsic pathways. Manuscript profile
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  3 - Vibrations of Multi-Layer Beam with Nanocomposite Face Sheets Reinforced with Graphene Platelets and Porous Core
  A Mihankhah Z Khoddami Maraghi A Ghorbanpour Arani Sh Niknejad
  10.22034/jsm.2023.1968296.1751
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  4 - On the Aeroelastic Stability of a Two-Directional FG GNP-Enriched Conical Shell
  A.R Shahidi A Darakhsh
  10.22034/jsm.2023.1985833.1776
  In this article, the supersonic flutter analysis of a truncated conical shell made of polymer enriched with graphene nanoplatelets (GNPs) exposed to supersonic fluid flow is discussed. It is assumed that the mass fraction of the GNPs is functionally graded (FG) along th More

  In this article, the supersonic flutter analysis of a truncated conical shell made of polymer enriched with graphene nanoplatelets (GNPs) exposed to supersonic fluid flow is discussed. It is assumed that the mass fraction of the GNPs is functionally graded (FG) along thickness and length directions according to different dispersion patterns. Modeling of the shell is done using the first-order shear deformation theory (FSDT), the mechanical properties are computed according to the Halpin-Tsai model alongside the rule of the mixture, and the aerodynamic pressure is computed utilizing the piston theory. Utilizing Hamilton’s principle, the boundary conditions and the governing equations are achieved. Harmonic trigonometric functions are used to provide an analytical solution in the circumferential direction and an approximate solution is presented in the meridional direction using the differential quadrature method (DQM). The efficacy of various parameters on the aeroelastic stability are discussed such as the percentage and dispersion pattern of the GNPs and gradient indices. It is observed that to achieve higher aeroelastic stability in the GNP-enriched truncated conical shells, it is better to dispense the GNPs near the small radius and the inner surface of the shell. Manuscript profile
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  5 - Macroscopic evaluation of the effect of platelet rich fibrin on second intention cutaneous wound healing in the dog
  Nosratollah Changizi داوود kazemi
  Platelet rich fibrin is a platelet concentrate which could influence wound healing due to the release of growth factors. The purpose of this study was macroscopic evaluation of the effect of topical platelet rich fibrin on second intention cutaneous wound healing. For t More

  Platelet rich fibrin is a platelet concentrate which could influence wound healing due to the release of growth factors. The purpose of this study was macroscopic evaluation of the effect of topical platelet rich fibrin on second intention cutaneous wound healing. For this purpose, 14 adult male dogs were used. Four full thickness 2.5 × 2.5 cm wounds were created on the back of each animal either side of the vertebral column. The left and right side wounds were used as treatment and control respectively. Postoperatively, the percentage of wound contraction, epithelialization and wound healing were calculated on days 7, 14, 21 and 28 and the means were compared between the two groups using the independent sample t-test at 95% significance level. The results indicated that on day 28, percentage of wound contraction was insignificantly lower in the treatment group (44.03±6.15 vs. 49.26±10.09) while epithelialization was insignificantly higher (85.90±10.32 vs. 66.24±13.45) in comparison to the control group. Also the percentage of wound healing was significantly (p=0.03) higher in the treatment group compared with the control group (92.55±5.14 vs. 83.85±3.69). Overall, the results indicated that platelet rich fibrin improves macroscopic aspects of second intention cutaneous wound healing. Manuscript profile
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  6 - Fabrication and Characterization of Chitosan/ Polycaprolactone Core-Shell Nanofiber Scaffold Containing Platelet-Rich Fibrin by Coaxial Electrospinning Method for Biomedical Applications
  AmirAbbas Rastegar Mahboobeh Mahmoodi Mohammad Mirjalili Navid Nasirzadeh
  10.30495/apme.2021.1910486.2014
  Platelet-rich fibrin (PRF) is a natural fibrin matrix containing platelets and growth factors in the blood that increases the bone tissue repair. In this study, polycaprolactone/chitosan (scaffold A) and polycaprolactone/chitosan core-shell scaffold containing PRF (scaf More

  Platelet-rich fibrin (PRF) is a natural fibrin matrix containing platelets and growth factors in the blood that increases the bone tissue repair. In this study, polycaprolactone/chitosan (scaffold A) and polycaprolactone/chitosan core-shell scaffold containing PRF (scaffold B) were fabricated by uniaxial electrospinning and coaxial electrospinning methods, respectively and were characterized. Surface morphology, fiber diameter, porosity, mechanical properties, and functional groups on the scaffolds surface were evaluated by scanning electron microscope (SEM) and transition electron microscopy (TEM), displacement liquid method, tensile strength test, and fourier transform infrared (FTIR) spectroscopy, respectively. The average fibers diameter of the scaffold B decreased to 160 nm as compared to 179 nm for the scaffold A. Also, the presence of chitosan containing PRF in the core with the formation of hydrogen bonding with polycaprolactone in the shell of the scaffold B caused a scaffold with excellent mechanical properties and elastic modulus 40 MPa. Cell viability and adherence of bone cells on the surface scaffolds were evaluated via MTT assay. Due to the present of PRF in the scaffold B, the bone cells growth and cells adhesion on the surface of scaffold B increased compared to the scaffold A. Therefore, according to the results of this study, the core-shell scaffold containing PRF can be a good suggestion for use in biomedical applications. Manuscript profile
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  7 - The Effects of Fe2ZnO4 Nanoparticles on Blood Cells of Male Wistar Rat
  A. Gerami M. Setorki Z. Hooshmandi
  Due to increased production and use of nanoparticles, extensive studies are needed to determine their toxicity and negative effects. The aim of this study was to evaluate the effect of Fe2ZnO4 nanoparticle on blood cell counts and hematocritpercentage. In this experimen More

  Due to increased production and use of nanoparticles, extensive studies are needed to determine their toxicity and negative effects. The aim of this study was to evaluate the effect of Fe2ZnO4 nanoparticle on blood cell counts and hematocritpercentage. In this experimental study, 24 male Wistar rats were randomly divided into groups of 8 rats. Group 1 received 0.5 ml of saline. Group 1 and 2 received 0.5ml of distillated water containing 100 and 200 ppm Fe2ZnO4for 7 successive days. Red blood cell count, white blood cell count and differential count, platelet count and hematocrit were determined 2, 7 and 14 days after treatment. Fe2ZnO4 lead to a significant reduction in RBC and a significant increase in WBC. Nanoparticles exposure increased neutrophil and lymphocyte percentage which reflects the heightened response of innate immune system against nanoparticles. Fe2ZnO4 also caused a significant reduction in blood platelet count and 200 ppm dose caused higher reduction (p Manuscript profile
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  8 - Comparison of therapeutic effects of Platelet Rich Plasma Gel and Phenytoin on healing of full thickness skin wound in New Zealand white rabbit
  , M Darestani Farahaani M. E Najafzadeh Khoei, فریبرز Moayer,
  Platelets Rich Plasma (PRP) technique, was introduced in 1987 and now is widely in use amongst in skin wound treatment . This study has been compared the effects of platelet-rich plasma and phenytoin on experimental fullthickness wounds in rabbits. A total of 15 health More

  Platelets Rich Plasma (PRP) technique, was introduced in 1987 and now is widely in use amongst in skin wound treatment . This study has been compared the effects of platelet-rich plasma and phenytoin on experimental fullthickness wounds in rabbits. A total of 15 healthy, adult male New Zealand rabbits with 1300 g (100 ± g) weight and 5 months (1 ± months) old age, were randomly divided in5 equal groups and were kept in individual cages. Heterologous PRP used in this study, was obtained via the collection of 10 mL blood from a mature New Zealand White male rabbits and centrifuged by two-steps procedure. Anesthesia were induced in rabbits by injecting of appropriate doses of xylazine and ketamine via the IM route , then performed pre-operative consideration ,and fnally a full-thickness wound with dimension of 1.5 × 1.5 cm created on both side of chest in all rabbits . Right and left wounds covered up with four drops of heterologous PRP and 0.5 Cm3 of phenytoin sodium (cream1%), respectively. During the 21-day period of the study, photographic images prepared from all wounds daily and then analyzed of wounds area and healing process, by Scion Image software. Under appropriate anesthesia in days of 3,5,7,14,21 after wound creation, histopathologic specimens were obtained from groups 1-5, respectively. The obtained data were analyzed in U MANN-Withney and T-Test. It was found different signifcance between days 14 to 21 only in wounds area and volume of granulation tissue in wounds treated with PRP v/s wounds treated with phenytoin sodium and there was no signifcant difference in other criteria’s (P <0.05).   Manuscript profile