Effect of Ginger Powder on Blood Coagulation Factors in Rats

Subject Areas : Journal of Animal Biology

Khatereh Safavi Naeine ¹ (Department of Pharmacology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran)
mina fardaei ² (Department of NursingArsanjan Branch, Islamic Azad University, Arsanjan, Iran.)

Received: 2024-01-23 Accepted : 2024-06-20 Published : 2024-08-06

Keywords: Ginger, Platelet, Fibrinogen, PT, PTT, Rat,

Abstract :

Ginger is used as a food, spice, and herbal supplement for its antioxidant, anti-inflammatory, and medicinal activities. Blood coagulation is the process that causes blood to clot. This process causes the conversion of fibrinogen to fibrin, the activation of coagulation factors, and the accumulation of platelets through two internal and external pathways. The purpose of this research is to investigate the effect of ginger on coagulation factors in male rats. 32 adult male Wistar rats with an approximate weight of 250 grams and 12 weeks old were randomly divided into 4 groups, the control group (without any treatment) and three groups treated with the dry powder of ginger plant at a dose of 20-40 and 60 mg per kilogram of body weight per day. The ginger powder was added to their diet for 7 days. In the end, by taking blood from the heart, the amount of platelets, fibrinogen, PT, and PTT was measured and then the data were analyzed using spss21 software and through one-way ANOVA tests, and Tukey's post hoc test and its graphs were drawn using Graph pad prism 5 software. The results of this research showed a significant increase in the amount of fibrinogen in the group treated with a dose of 20 milligrams per kilogram of weight compared to the control group, a significant decrease in the amount of PT in the group treated with a dose of 60 milligrams per kilogram of weight compared to all three groups, a significant increase in the number of platelets in the group treated with a dose of 40 mg per kilogram of weight compared to the control group. Also, no significant differences were observed in PTT. The research results show that ginger can cause changes in blood coagulation factors in rats.

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